六氯苯

六氯苯 基本信息
CAS号 118-74-1 分子式 C6Cl6
分子量 284.78 精确质量 　281.81312
PSA 　0.00 A2 LogP 　5.749±0.355
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目录
基本信息 制备方法与用途 物化性质 安全信息 化学图谱 毒性 MSDS 海关数据 结构与计算数据 上下游

基本信息 展开↓

CAS号：
118-74-1
3D弹球模型：
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分子式：
C6Cl6
分子量：
284.78
中文名称：
六氯苯
英文名称：
Benzene, 1,2,3,4,5,6-hexachloro-
中文别名：
六氯苯;
六氯代苯;
全氯代苯;
灭黑穗药;
六氯苯13C6;
六氯苯(HCB);
气相色谱/质谱联用仪校准用;
过氯苯
英文别名：
Benzene, 1,2,3,4,5,6-hexachloro-;
hexachlorobenzene;
Hexachlorobenzene;
perchlorobenzene;
Hexachlorobenzene 13C6;
HCB;
Hexachlorobenzene solution
精确分子量/精确质量：
281.81312
极性分子表面积/PSA：
0.00 A2
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
贝尔斯坦号/MDL：
MFCD00000540
EINECS：
204-273-9
PubChem：
24869041
BRN：
1912585
InChI：
InChI=1/C6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9

生产制备方法及用途展开↓

制备方法

1.三氯苯氯法将三氯苯加热至110℃,保温干燥1h,能氯气氯化,反应时放出热量,起始温度100-120℃,最终温度为260-270℃,氯化10-14h,当温度开始下降时即表示氯化反应已达终点,停止通氯,将熔融的物料放入盛水的结晶箱,搅拌下六氯苯结晶成粒。用冷水洗涤,即得六氯苯。 2.六六六无效体直接氯化法无效体经热风干燥至含水量在1%以下,加入熔融釜中,加热至150-170℃熔化,然后加入洗涤器和氯化塔。洗涤器温度保持在210-230℃,氯化塔通氯后,依照反应热慢慢升温,控制通氯速度,使反应温度每小时上升2-3℃。氯化塔的含氯尾气通入洗涤器吸收后送至副产盐酸系统。当氯化温度达260-270℃,并迅速放入盛水的结晶罐中骤冷结晶即得成品。

合成制备方法

1.三氯苯氯法将三氯苯加热至110℃，保温干燥1h，能氯气氯化，反应时放出热量，起始温度100-120℃，最终温度为260-270℃，氯化10-14h，当温度开始下降时即表示氯化反应已达终点，停止通氯，将熔融的物料放入盛水的结晶箱，搅拌下六氯苯结晶成粒。用冷水洗涤，即得六氯苯。

2.六六六无效体直接氯化法无效体经热风干燥至含水量在1%以下，加入熔融釜中，加热至150-170℃熔化，然后加入洗涤器和氯化塔。洗涤器温度保持在210-230℃，氯化塔通氯后，依照反应热慢慢升温，控制通氯速度，使反应温度每小时上升2-3℃。氯化塔的含氯尾气通入洗涤器吸收后送至副产盐酸系统。当氯化温度达260-270℃，并迅速放入盛水的结晶罐中骤冷结晶即得成品。

用途简介

1.用作拌种杀菌剂,可防治小麦腥黑穗病和杆黑穗病。用于生产花炮,作焰火色剂。 2.用作五氯酚及五氯酚钠的原料。 3.有机元素微量分析时用做氯的标准,也用于有机合成。 4.用于防治麦类黑穗病,种子和土壤消毒。

用途

1.用作拌种杀菌剂，可防治小麦腥黑穗病和杆黑穗病。用于生产花炮，作焰火色剂。

2.用作五氯酚及五氯酚钠的原料。

3.有机元素微量分析时用做氯的标准，也用于有机合成。

4.用于防治麦类黑穗病，种子和土壤消毒。[27]

物化性质展开↓

外观与性状：
白色粉末
密度：
1.767±0.06 g/cm3
熔点：
80 °C
沸点：
324.5±0.0 °C
闪点：
151.1±23.9 °C
水溶解性：
Sparingly Soluble (4.3E-5 g/L)
折射率：
1.606
蒸汽压：
0.000463mmHg at 25°C
蒸汽密度：
4.63E-4 Torr
存储条件/存储方法：
库房通风低温干燥,与食品原料分开储运
稳定性相关：

1.稳定性[21]  稳定

2.禁配物[22]  强氧化剂

3.避免接触的条件[23]  受热

4.聚合危害[24]  不聚合

5.分解产物[25]  氯化氢

其它信息：

1.性状：纯品为无色细针状或小片状晶体，工业品为淡黄色或淡棕色晶体。[1]

2.熔点（℃）：229~231[2]

3.沸点（℃）：323~326（升华）[3]

4.相对密度（水=1）：2.044[4]

5.相对蒸气密度（空气=1）：9.8[5]

6.饱和蒸气压（kPa）：0.13（114.4℃）[6]

7.临界压力（MPa）：2.85[7]

8.辛醇/水分配系数：5.73[8]

9.闪点（℃）：242[9]

10.溶解性：不溶于水，溶于乙醚、氯仿、苯等多数有机溶剂。[10]

11.溶度参数(J·cm-3)0.5：20.395

12.van der Waals面积（cm2·mol-1）：1.272×1010

13.van der Waals体积（cm3·mol-1）：106.700

14.晶相标准声称热(焓)( kJ·mol-1)：-127.6

15.晶相标准熵(J·mol-1·K-1) ：260.24

16.晶相标准生成自由能( kJ·mol-1)：4.4

17.气相标准生成自由能( kJ·mol-1)：44.1

18.气相标准热熔(J·mol-1·K-1)：175.2

19.气相标准声称热(焓)( kJ·mol-1) ：-35.5

20.气相标准熵(J·mol-1·K-1) ：436.73

安全信息展开↓

包装等级：
III
风险类别：
6.1(b)
海关代码：
2903920000
WGK_Germany：
3
德国有关水污染物质的分类清单
危险类别码：
R45;R48/25;R50/53
安全说明：
S53-S45-S60-S61-S62-S36/37-S33-S29-S16-S9-S26
RTECS号：
DA2975000
安全标志：
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
S53:避免暴露——使用前先阅读专门的说明。
S60:本物质残余物和容器必须作为危险废物处理。
S61:避免排放到环境中。参考专门的说明/安全数据表。
危险标志：
T:Toxic;N:Dangerousfortheenvironment;

化学图谱

  1. 六氯苯质谱(MS)

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毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DA2975000
CHEMICAL NAME :
Benzene, hexachloro-
CAS REGISTRY NUMBER :
118-74-1
BEILSTEIN REFERENCE NO. :
1912585
LAST UPDATED :
199712
DATA ITEMS CITED :
68
MOLECULAR FORMULA :
C6-Cl6
MOLECULAR WEIGHT :
284.76
WISWESSER LINE NOTATION :
GR BG CG DG EG FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3600 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
1600 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1800 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
>6400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2022 mg/kg/55D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1596 mg/kg/28D-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3326 mg/kg/15W-I
TOXIC EFFECTS :
Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2100 mg/kg/6W-I
TOXIC EFFECTS :
Liver - other changes Biochemical - Metabolism (Intermediary) - porphyrin including bile pigments
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1729 mg/kg/13W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Endocrine - adrenal cortex hyperplasia Blood - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
250 mg/kg/5W-I
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1500 mg/kg/60D-C
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1512 mg/kg/18W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - Plasma proteins not involving coagulation
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
842 mg/kg/6W-C
TOXIC EFFECTS :
Immunological Including Allergic - decrease in humoral immune response
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
36400 mg/kg/1Y-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
3840 mg/kg/60D-I
TOXIC EFFECTS :
Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Endocrine - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - pig
DOSE/DURATION :
455 mg/kg/13W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in thyroid weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
4704 mg/kg/28W-C
TOXIC EFFECTS :
Endocrine - changes in thymus weight Endocrine - changes in thyroid weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
5 gm/kg/10D-I
TOXIC EFFECTS :
Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
2500 mg/kg/5D-I
TOXIC EFFECTS :
Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2738 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Blood - leukemia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6972 mg/kg/83W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Liver - tumors Blood - lymphoma, including Hodgkin's disease
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
1000 mg/kg/18W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Endocrine - thyroid tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
3360 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
3360 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5475 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - Kidney tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1050 mg/kg/30W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Liver - tumors Biochemical - Metabolism (Intermediary) - porphyrin including bile pigments
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6300 mg/kg/90W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
556 mg/kg
SEX/DURATION :
female 96 day(s) pre-mating - 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
40 mg/kg
SEX/DURATION :
female 10-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6450 mg/kg
SEX/DURATION :
female 1-22 day(s) after conception lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) Reproductive - Specific Developmental Abnormalities - immune and reticuloendothelial system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
88 mg/kg
SEX/DURATION :
male 70 day(s) pre-mating female 70 day(s) pre-mating - 22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
812 mg/kg
SEX/DURATION :
multigenerations
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
212 mg/kg
SEX/DURATION :
female 14 day(s) pre-mating - 17 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1 gm/kg
SEX/DURATION :
female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
600 mg/kg
SEX/DURATION :
female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - biochemical and metabolic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
625 mg/kg
SEX/DURATION :
female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
910 ug/kg
SEX/DURATION :
female 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
27562 ug/kg
SEX/DURATION :
female 66 day(s) pre-mating - 28 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TYPE OF TEST :
Mutation test systems - not otherwise specified

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
6 mg/L
REFERENCE :
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year: 39,359,1986 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.002 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 20,155,1979 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,219,1987 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,219,1987 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 56,107,1975 TOXICOLOGY REVIEW JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 183,88,1963 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FRANCE;Carcinogen JAN 1993 OEL-RUSSIA:STEL 0.9 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1753 No. of Facilities: 10 (estimated) No. of Industries: 2 No. of Occupations: 12 No. of Employees: 1038 (estimated) No. of Female Employees: 26 (estimated)
毒理学数据：

1.急性毒性[11] 

LD50：3500mg/kg（大鼠经口）；4000mg/kg（小鼠经口）；2600mg/kg（兔经口）

2.刺激性  暂无资料

3.亚急性与慢性毒性[12]  动物亚急性和慢性毒性反应有神经毒性症状，肝、肾重量增加，尿中粪卟啉排泄增加等。

4.致突变性[13]  DNA损伤：鼠伤寒沙门菌20μmol/L。微生物致突变：酿酒酵母菌100ppm。DNA加合物：大肠杆菌20μmol/L。哺乳动物体细胞突变：仓鼠肺6mg/L。

5.致畸性[14]  大鼠孕后10~13d经口给予最低中毒剂量（TDLo）40mg/kg，致肌肉骨骼系统发育畸形。大鼠孕后1~22d经口给予最低中毒剂量（TDLo）6450mg/kg，致血液和淋巴系统（包括脾和骨髓）、免疫和网状内皮系统发育畸形。小鼠孕后7~16d经口给予最低中毒剂量（TDLo）1g/kg，颅面部（包括鼻、舌）、泌尿系统发育畸形。雌鼠交配前14d经口给予最低中毒剂量（TDLo）100mg/kg，致中枢神经系统发育畸形。

6.致癌性[15]  IARC致癌性评论：G2B，可疑人类致癌物。

7.其他[16]  大鼠经口最低中毒剂量（TDLo）：40mg/kg（孕后10~13d用药），对胎鼠肌肉、骨骼系统有影响。小鼠经口最低中毒剂量（TDLo）：1g/kg，有胚胎毒性，对泌尿生殖系统有影响。

生态数据：

1.生态毒性[17]

LC50：22mg/L（96h）（黑头呆鱼，静态）；12mg/L（96h）（蓝鳃太阳鱼，静态）

2.生物降解性[18]

好氧生物降解（h）：23256~50136

厌氧生物降解（h）：93024~200544

3.非生物降解性[19]

光解最大光吸收波长范围（nm）：291~301

空气中光氧化半衰期（h）：3753~37530

4.生物富集性[20]  BCF：11000~27000（鲤鱼，接触浓度0.5ppb，接触时间8周）；6000~30000（鲤鱼，接触浓度0.05ppb，接触时间8周）

MSDS 展开↓

国标编号: 61876
ＣＡＳ: 118-74-1
中文名称: 六氯苯
英文名称: Hexachlorobenzene；Hexachlorbenzd
别 名: 灭黑穗药
分子式: C6Cl6
分子量: 284.78
熔 点: 226℃ 沸点：323～326
密 度: 相对密度(水=1)2.44；
蒸汽压: 242℃
溶解性: 不溶于水，溶于乙醚、氯仿等多数有机溶剂
稳定性: 稳定
外观与性状: 纯品为无色细针状或小片状晶体，工业品为淡黄色或淡棕色晶体
危险标记: 14(有毒品)
用 途: 用作防治麦类黑穗病，种子和土壤消毒

2.对环境的影响:
一、健康危害

 侵入途径：吸入、食入。
健康危害：中毒时能影响肝脏、中枢神经系统和心血管系统。用本品拌种时引起眼刺激、烧灼感、口鼻发干、疲乏、头痛、恶心等。可致皮肤溃疡。接触者尿和粪中有大量紫质排出。
二、毒理学资料及环境行为

急性毒性：LD503500mg/kg(大鼠经口)；4000mg/kg(小鼠经口)
亚急性和慢性毒性：动物亚急性和慢性毒性反应有神经毒性症状，肝、肾重量增加，尿中粪卟啉排泄增加等。
致突变性：DNA损伤：鼠伤寒沙门氏菌20umol/L。微粒体致突变：制酒酵母菌100ppm。
生殖毒性：大鼠经口最低中毒剂量(TDL0)：40mg/kg(孕后10～13天用药)，对胎鼠肌肉、骨骼系统有影响。小鼠经口最低中毒剂量(TDL0)：1g/kg，有胚胎毒性，对泌尿生殖系统有影响。
致癌性：IARC致癌性评论：人为可疑性反应，动物为阳性反应。
   危险特性：不易燃烧。受高热分解产生有毒腐蚀性烟气。
   燃烧(分解)产物：一氧化碳、二氧化碳、氯化氢。

3.现场应急监测方法:


　

4.实验室监测方法:


气相色谱法《水和废水监测分析方法》(第三版)国家环保局编
气相色谱法《固体废弃物试验分析评价手册》中国环境监测总站等译

5.环境标准:

前苏联 车间空气中有害物质的最高容许浓度 0.9mg/m3
前苏联(1977)   居民区大气中有害物最大允许浓度 0.03mg/m3(最大值，昼夜均值)
中国(待颁布) 饮用水源中有害物质的最高容许浓度 0.05mg/L
中国(GHZB1-1999) 地表水环境质量标准(I、II、III类水域) 0.05mg/L


6.应急处理处置方法:


一、泄漏应急处理

隔离泄漏污染区，周围设警告标志，切断火源。应急处理人员戴好防毒面具，穿一般消防防护服。用洁净的铲子收集于干燥洁净有盖的容器中，用水泥、沥青或适当的热塑性材料固化处理再废弃。如大量泄漏，收集回收或无害处理后废弃。
废弃物处置方法：目前处置方法包括焚烧法、深井灌注法和填埋法。最有效的方法是焚烧法。
二、防护措施

呼吸系统防护：可能接触其粉尘时，应该佩戴防毒口罩。紧急事态抢救或撤离时，建议佩戴自给式呼吸器。
眼睛防护：必要时戴化学安全防护眼镜。
防护服：穿工作服。
手防护：戴防化学品手套。
其它：工作现场禁止吸烟、进食和饮水。工作后，彻底清洗。及时换洗工作服。注意个人清洁卫生。
三、急救措施

皮肤接触：脱去污染的衣着，用大量清水彻底冲洗。
眼睛接触：立即翻开上下眼睑，用流动清水或生理盐水冲洗。就医。
吸入：迅速脱离现场至空气新鲜处。保持呼吸道通畅。呼吸困难时给输氧。呼吸停止时，立即进行人工呼吸。就医。
食入：给饮足量温水，催吐。就医。

  灭火方法：雾状水、泡沫、二氧化碳、干粉、砂土。

海关数据查看详细

中国海关编码：2903920000

概述：
2903920000 六氯苯(ISO)及滴滴涕(ISO,INN)〔六氯苯别名过氯苯,滴滴涕别名[1,1,1-三氯-2,2-双（4-氯苯基）乙烷]〕。监管条件:89(禁止出口商品,禁止进口商品)。增值税率:17.0%。退税率:0.0%。最低关税:5.5%。普通关税:30.0%
申报要素：
品名, 成分含量, 用途
监管条件：
8.禁止出口商品9.禁止进口商品
摘要/Summary：
2903920000 perchlorobenzene。supervision conditions:89(articles on the list of prohibited export goods,articles on the list of prohibited import goods)。VAT:17.0%。tax rebate rate:0.0%。MFN tarrif:5.5%。general tariff:30.0%

分子结构与计算化学数据展开↓

分子结构数据

1、摩尔折射率：55.62

2、摩尔体积（cm3/mol）：161.1

3、等张比容（90.2K）：422.4

4、表面张力（dyne/cm）：47.2

5、极化率（10-24cm3）：22.05

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:0

3.氢键受体数量:0

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积0

7.重原子数量:12

8.表面电荷:0

9.复杂度:104

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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