CAS号：

25013-16-5

分子式：

C11H16O2

分子量：

180.2435

中文名称：

叔丁基-4-羟基苯甲醚

英文名称：

Butylated hydroxyanisole

中文别名：

叔丁基-4-羟基苯甲醚;
丁羟茴香醚;
丁基羟基茴香醚;
2(3)-叔-丁基-4-甲氧基苯酚;
抗氧化剂BHA;
叔丁基对羟基茴香醚;
叔丁基-4-羟基茴香醚;
5-(benzyloxy)-2-bromo-4-methoxybenzoic acid;
3-Benzyloxy-4-methoxy-6-bromoben;
5-Benzyloxy-2-Bromo-4-Methoxybenzoic Acid;
3-Benzyloxy-4-methoxy-6-bromobenzoic acid;
2-BROMO-4-METHOXY-5-(BENZYLOXY)BENZOIC ACID;
but-3-enoic acid-ethene (1:1);
Ethylene/vinyl acetate copolymer;
P-Dhp;
Pregn-4-ene-3,20-dione, 16,17-((1-phenylethylidene)bis(oxy))-, (16alpha(R))-;
SQ 15101;
UNII-OL7KC2O3OT;
(R)-16alpha,17-((1-Phenylethylidene)dioxy)pregn-4-ene-3,20-dione;
Pregn-4-ene-3,20-dione, 16-alpha,17-dihydroxy-, cyclic acetal with acetophenone, (R)-;
(4bS,6bS,9aR,10aS)-6b-acetyl-4a,6a,8-trimethyl-8-phenyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one;
(4aR,4bS,6aS,6bS,8R,9aR,10aS,10bR)-6b-acetyl-4a,6a,8-trimethyl-8-phenyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11;
Algestone Acetophenide

英文别名：

Butylated hydroxyanisole;
2(3)-tert-Butyl-4-hydroxyanisole;
antioxyne b;
BHA;
BOA;
Butyl Hydroxyanisole;
tert-butyl-4-hydroxyanisole;
tert-butyl-4-methoxyphenol;
tert-butylhydroxyanisole;
Vertac;
Butylated hydroxy anisole;
2-tert-butyl-4-methoxyphenol - 3-tert-butyl-4-methoxyphenol (1:1);
4-methoxyphenol - 2,2-dimethylpropane (1:1);
2-butyl-6-methoxyphenol;
Pregn-4-ene-3,20-dione, 16,17-((1-phenylethylidene)bis(oxy))-, (16alpha(R))-;
SQ 15101;
UNII-OL7KC2O3OT;
(R)-16alpha,17-((1-Phenylethylidene)dioxy)pregn-4-ene-3,20-dione;
Pregn-4-ene-3,20-dione, 16-alpha,17-dihydroxy-, cyclic acetal with acetophenone, (R)-;
(4bS,6bS,9aR,10aS)-6b-acetyl-4a,6a,8-trimethyl-8-phenyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one;
(4aR,4bS,6aS,6bS,8R,9aR,10aS,10bR)-6b-acetyl-4a,6a,8-trimethyl-8-phenyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11;
Algestone Acetophenide

贝尔斯坦号/MDL：

MFCD01779059

EINECS：

246-563-8

InChI：

InChI=1/C11H16O2/c1-3-4-6-9-7-5-8-10(13-2)11(9)12/h5,7-8,12H,3-4,6H2,1-2H3

合成制备方法

1.中间体对羟基苯甲醚的制备
将对氨基苯甲醚和亚硝酸钠按1：1.15加入反应釜，在硫酸的存在下进行重氮化；反应完毕后保温过滤，并将滤液缓慢滴进热水中进行水解；生成的对羟基苯甲醚立刻用蒸汽提馏出来，冷凝后用苯萃取；除去溶剂，即得产品，平均收率为84.7%。
CH3OC6H4NH2+NaNO2[H2SO4]→CH3OC6H4N2HSO4[H2O]→CH3OC6H4OH

2.BHA的合成
将溶剂苯、叔丁醇和对羟基苯甲醚依次加入反应釜加热溶解，然后加入催化剂磷酸或硫酸，于80℃强烈搅拌下回流反应；反应完毕后，放料静置分层；有机相先后用10%的氢氧化钠溶液和水洗至中性，除去溶剂，再经乙醇重结晶即得成品。

3.以对氨基苯甲醚和亚硫酸钠为原料，在硫酸的存在下进行重氮化，经过滤、水解、蒸馏制得。或者将溶剂苯、叔丁醇和对羟基苯甲醚依次加入反应釜加热溶解，在催化剂作用下反应，经洗涤、蒸馏和重结晶得成品。