CHEMICAL IDENTIFICATION

RTECS NUMBER :

TK1455000

CHEMICAL NAME :

Pilocarpine, mononitrate

CAS REGISTRY NUMBER :

148-72-1

LAST UPDATED :

199701

DATA ITEMS CITED :

10

MOLECULAR FORMULA :

C11-H16-N2-O2.H-N-O3

MOLECULAR WEIGHT :

271.31

WISWESSER LINE NOTATION :

T5OVTJ C2 D1- ET5N CNJ A1 &WNO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

911 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Behavioral - fluid intake Kidney, Ureter, Bladder - urine volume decreased

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

345 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

15600 mg/kg/15W-I

TOXIC EFFECTS :

Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - urine volume increased Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

2200 mg/kg

SEX/DURATION :

female 1-22 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - skin and skin appendages

TYPE OF TEST :

Micronucleus test

TYPE OF TEST :

Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :

Rodent - mouse

DOSE/DURATION :

8 mg/kg

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 344,103,1995 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81934 No. of Facilities: 42 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 980 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81934 No. of Facilities: 22 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1525 (estimated) No. of Female Employees: 1273 (estimated)

毒理学数据：

二、毒理学数据：

1、急性毒性：小鼠静脉LD50：345 mg/kg；

大鼠经口LD50：911 mg/kg

2、   生殖毒性：大鼠皮下TDLo：2200 mg/kg

生态数据：

三、生态学数据：

其它有害作用：该物质对环境可能有危害，对水体应给予特别注意。