茶丙洛尔

茶丙洛尔 基本信息
CAS号 65184-10-3 分子式 C23H30N6O4
分子量 454.52200 精确质量 　454.23300
PSA 　119.10000 LogP 　1.42240
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目录
基本信息 物化性质 毒性

基本信息 展开↓

CAS号：
65184-10-3
3D弹球模型：
立即前往扯扯看
分子式：
C23H30N6O4
分子量：
454.52200
中文名称：
茶丙洛尔
英文名称：
7-[3-[[2-hydroxy-3-[(2-methyl-1H-indol-4-yl)oxy]propyl]amino]butyl]-1,3-dimethylpurine-2,6-dione
中文别名：
茶丙洛尔
英文别名：
7-[3-[[2-hydroxy-3-[(2-methyl-1H-indol-4-yl)oxy]propyl]amino]butyl]-1,3-dimethylpurine-2,6-dione;
Teoprololum [INN-Latin];
Teoprolol;
1H-Purine-2,6-dione,3,7-dihydro-7-(3-((2-hydroxy-3-((2-methyl-1H-indol-4-yl)oxy)propyl)amino)butyl)-1,3-dimethyl;
EINECS 265-600-9;
7-{3-[2-hydroxy-3-(2-methyl-indol-4-yloxy)-propylamino]-butyl}-1,3-dimethyl-3,7-dihydro-purine-2,6-dione;
7-(3-((2-Hydroxy-3-((2-methylindol-4-yl)oxy)propyl)amino)butyl)theophylline;
D-13,312;
Teoprololum
精确分子量/精确质量：
454.23300
极性分子表面积/PSA：
119.10000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
InChI：
The Key: HITMZSXZYGLDCV-UHFFFAOYSA-N

物化性质展开↓

密度：
1.37g/cm3
沸点：
747.6ºC at 760 mmHg
闪点：
405.9ºC
折射率：
1.665

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UO8437700
CHEMICAL NAME :
1H-Purine-2,6-dione, 3,7-dihydro-7-(3-((2-hydroxy-3-((2-methyl-1H-indol-4- yl)oxy)propyl) amino)butyl)-1,3-dimethyl-
CAS REGISTRY NUMBER :
65184-10-3
BEILSTEIN REFERENCE NO. :
1234202
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C23-H30-N6-O4
MOLECULAR WEIGHT :
454.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1870 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
39 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
38 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982
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