葡糖硫金

葡糖硫金 基本信息
CAS号 12192-57-3 分子式 C6H11AuO5S
分子量 392.18000 精确质量 　391.99900
PSA 　115.45000 LogP 　-2.01870
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目录
基本信息 制备方法与用途 物化性质 安全信息 毒性 结构与计算数据

基本信息 展开↓

CAS号：
12192-57-3
分子式：
C6H11AuO5S
分子量：
392.18000
中文名称：
葡糖硫金
英文名称：
Aurothioglucose
中文别名：
葡糖硫金;
1-硫代-D-呋喃葡萄糖亚金盐;
D-硫代葡糖金;
金硫葡糖
英文别名：
Aurothioglucose;
oronol;
solganal;
romosol;
brenol;
gtg;
aurotan;
authron;
aurumine;
aureotan
精确分子量/精确质量：
391.99900
极性分子表面积/PSA：
115.45000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
贝尔斯坦号/MDL：
MFCD00056080
EINECS：
235-365-7
PubChem：
24724383

生产制备方法及用途展开↓

制备方法

用于在啮齿动物实验中产生肥胖症。治风湿药。

用途简介

用途

用于在啮齿动物实验中产生肥胖症。治风湿药。

物化性质展开↓

存储条件/存储方法：
通风低温干燥
其它信息：

 

1.      性状：黄色结晶。微有硫醇样气味。有强吸湿性。

2.      密度（g/mL,25/4℃）： 未确定

3.      相对蒸汽密度（g/mL,空气=1）：未确定

4.      熔点（ºC）：未确定

5.      沸点（ºC,常压）：未确定

6.      沸点（ºC,5.2kPa）：未确定

7.      折射率：未确定

8.      闪点（ºC）：未确定

9.      比旋光度（º）：未确定

10.   自燃点或引燃温度（ºC）：未确定

11.   蒸气压（kPa,25ºC）：未确定

12.   饱和蒸气压（kPa,60ºC）：未确定

13.   燃烧热（KJ/mol）：未确定

14.   临界温度（ºC）：未确定

15.   临界压力（KPa）：未确定

16.   油水（辛醇/水）分配系数的对数值：未确定

17.   爆炸上限（%,V/V）：未确定

18.   爆炸下限（%,V/V）：未确定

19.   溶解性：溶于水同时分解，微溶于乙醇。植物和其他大多数有机溶剂。有毒。

 

安全信息展开↓

包装等级：
III
风险类别：
6.1(b)
危险类别码：
R42/43
安全标志：
S22:不要吸入粉尘。
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
:
危险标志：
Xn: Harmful;

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MD6475000
CHEMICAL NAME :
Gold, (1-thio-D-glucopyranosato)-
CAS REGISTRY NUMBER :
12192-57-3
LAST UPDATED :
199606
DATA ITEMS CITED :
19
MOLECULAR FORMULA :
C6-H11-O5-S.Au
MOLECULAR WEIGHT :
392.20
WISWESSER LINE NOTATION :
T6OTJ BS-AU-H CQ DQ EQ F1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
5500 ug/kg/10W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cough Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 88,644,1995
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
2600 ug/kg/15D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Liver - other changes
REFERENCE :
ARHEAW Arthritis and Rheumatism. (Arthritis Foundation, 1314 Spring St., NW, Atlanta, GA 30309) V.1- 1958- Volume(issue)/page/year: 27,230,1984
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
3357 ug/kg/4W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont., Canada) V.1- 1974- Volume(issue)/page/year: 12,619,1985
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
2700 ug/kg/4W-I
TOXIC EFFECTS :
Liver - jaundice, cholestatic
REFERENCE :
JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont., Canada) V.1- 1974- Volume(issue)/page/year: 11,843,1984
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SAVEAB Sammlung von Vergiftungsfaellen. (Berlin, Germany) V.1-13, 1930-44; V.14, 1952-54. For publisher information, see ARTODN. Volume(issue)/page/year: 10,101A,1939
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 70,498,1949
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1650 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EMSUA8 Experimental Medicine and Surgery. (Brooklyn, NY) V.1-29, 1943-71. Suspended. Volume(issue)/page/year: 3,146,1945
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
POSCAL Poultry Science. (Poultry Science Assoc., Inc., 309 W. Clark St., Champaign, IL 61820) V.1- 1921- Volume(issue)/page/year: 52,926,1973
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Spinal Cord - other degenerative changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 35,223,1976 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 3,37,1959
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Musculoskeletal - tumors
REFERENCE :
RFECAC Revue Francaise d'Etudes Cliniques et Biologiques. (Paris, France) V.1-14, 1956-69. For publisher information, see BIMDB3. Volume(issue)/page/year: 13,40,1968
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors
REFERENCE :
RFECAC Revue Francaise d'Etudes Cliniques et Biologiques. (Paris, France) V.1-14, 1956-69. For publisher information, see BIMDB3. Volume(issue)/page/year: 11,828,1966 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
400 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 124,1190,1967
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
DOSE :
800 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 78,845,1966 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 13,39,1977 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 13,39,1977 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year: 13(1),209,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1852 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 7622 (estimated) No. of Female Employees: 7177 (estimated)
毒理学数据：

主要的刺激性影响：

在皮肤上面：刺激皮肤和粘膜

在眼睛上面：刺激的影响

致敏作用：没有已知的敏化现象

分子结构与计算化学数据展开↓

分子结构数据

1、摩尔折射率：无可用的

2、摩尔体积（cm3/mol）：无可用的

3、等张比容（90.2K）：无可用的

4、表面张力（dyne/cm）：无可用的

5、介电常数：无可用的

6、极化率（10-24cm3）：无可用的

7、单一同位素质量：391.999218 Da

8、标称质量：392 Da

9、平均质量：392.1801 Da

计算化学数据

1、   氢键供体数量：4

2、   氢键受体数量：6

3、   可旋转化学键数量：1

4、   拓扑分子极性表面积（TPSA）：90.2

5、   重原子数量：13

6、   表面电荷：0

7、   复杂度：155

8、   同位素原子数量：0

9、   确定原子立构中心数量： 4

10、   不确定原子立构中心数量：1

11、   确定化学键立构中心数量：0

12、   不确定化学键立构中心数量：0

13、   共价键单元数量：2

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