Version 1.2
    Regulation (EC) No 1907/2006

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    1 - Product and Company Information

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    Product Name        ACIVICIN    

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    2 - Hazards Identification

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    SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
    Harmful by inhalation, in contact with skin and if swallowed.

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    3 - Composition/Information on Ingredients

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    Product Name        CAS #        EC no        Annex I    
    Index Number
    ACIVICIN        42228-92-2 None        None    
    Formula        C5H7ClN2O3    
    Molecular Weight 178,6000 AMU
    Synonyms        Acivicine *    
    (alpha-S,5S)-alpha-Amino-3-chloro-4,5-dihydro-5-i
    soxazoleacetic acid * Antibiotic AT 125 * AT 125
    *
    (S-(R*,R*))-4,5-Dihydro-alpha-amino-3-chloro-5-is
    oxazoleacetic acid * NSC-163501 * U 42126

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    4 - First Aid Measures

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    AFTER INHALATION
    If inhaled, remove to fresh air. If breathing becomes difficult,
    call a physician.
    AFTER SKIN CONTACT
    In case of skin contact, flush with copious amounts of water for
    at least 15 minutes. Remove contaminated clothing and shoes.
    Call a physician.
    AFTER EYE CONTACT
    In case of contact with eyes, flush with copious amounts of
    water for at least 15 minutes. Assure adequate flushing by
    separating the eyelids with fingers. Call a physician.
    SIGMA        www.molbase.com    
    AFTER INGESTION
    If swallowed, wash out mouth with water provided person is
    conscious. Call a physician.

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    5 - Fire Fighting Measures

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    EXTINGUISHING MEDIA
    Suitable: Water spray. Carbon dioxide, dry chemical powder, or
    appropriate foam.
    SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
    Wear self-contained breathing apparatus and protective clothing
    to prevent contact with skin and eyes.

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    6 - Accidental Release Measures

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    PROCEDURE(S) OF PERSONAL PRECAUTION(S)
    Wear respirator, chemical safety goggles, rubber boots, and
    heavy rubber gloves.
    METHODS FOR CLEANING UP
    Sweep up, place in a bag and hold for waste disposal. Avoid
    raising dust. Ventilate area and wash spill site after material
    pickup is complete.

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    7 - Handling and Storage

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    STORAGE
    Store at 2-8°C

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    8 - Exposure Controls / Personal Protection

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    ENGINEERING CONTROLS
    Mechanical exhaust required.
    PERSONAL PROTECTIVE EQUIPMENT
    Special Protective Measures: Wear appropriate government approved
    respirator, chemical-resistant gloves, safety goggles, other
    protective clothing.

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    9 - Physical and Chemical Properties

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    Appearance        Physical State: Solid    
    Property        Value        At Temperature or Pressure    
    pH        N/A    
    BP/BP Range        N/A    
    MP/MP Range        N/A    
    Flash Point        N/A    
    Flammability        N/A    
    Autoignition Temp        N/A    
    Oxidizing Properties        N/A    
    Explosive Properties        N/A    
    Explosion Limits        N/A    
    Vapor Pressure        N/A    
    Partition Coefficient        N/A    
    Viscosity        N/A    
    Vapor Density        N/A    
    Saturated Vapor Conc.        N/A    
    SIGMA        www.molbase.com    
    Evaporation Rate        N/A    
    Bulk Density        N/A    
    Decomposition Temp.        N/A    
    Solvent Content        N/A    
    Water Content        N/A    
    Surface Tension        N/A    
    Conductivity        N/A    
    Miscellaneous Data        N/A    
    Solubility        N/A    

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    10 - Stability and Reactivity

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    STABILITY
    Stable: Stable.
    HAZARDOUS DECOMPOSITION PRODUCTS
    Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
    Nitrogen oxides, Hydrogen chloride gas.
    HAZARDOUS POLYMERIZATION
    Hazardous Polymerization: Will not occur

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    11 - Toxicological Information

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    RTECS NUMBER: NY2103000
    SIGNS AND SYMPTOMS OF EXPOSURE
    Exposure can cause gastrointestinal disturbances, nausea,
    diarrhea, vomiting, myelosuppression, nightmares,
    hallucinations, paranoia, hematopoietic toxicity, and adverse
    CNS effects. In males, exposure can cause adverse effects on the
    reproductive system causing cessation of sperm production and
    degeneration of the testicles and of the seminiferous tubules.
    ROUTE OF EXPOSURE
    Multiple Routes: Harmful if swallowed, inhaled, or absorbed
    through skin.
    CHRONIC EXPOSURE - MUTAGEN
    Mouse
    250 MG/KG
    Intraperitoneal
    Micronucleus test
    Chicken
    6 UMOL/L
    Cell Type: Embryo
    DNA inhibition

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    12 - Ecological Information

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    No data available.

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    13 - Disposal Considerations

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    SUBSTANCE DISPOSAL
    Dissolve or mix the material with a combustible solvent and burn
    in a chemical incinerator equipped with an afterburner and
    scrubber. Observe all federal, state, and local environmental
    SIGMA        www.molbase.com    
    regulations.

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    14 - Transport Information

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    RID/ADR
    Non-hazardous for road transport.
    IMDG
    Non-hazardous for sea transport.
    IATA
    Non-hazardous for air transport.

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    15 - Regulatory Information

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    CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
    INDICATION OF DANGER: Xn
    Harmful.
    R-PHRASES: 20/21/22
    Harmful by inhalation, in contact with skin and if swallowed.
    S-PHRASES: 36
    Wear suitable protective clothing.
    Caution: Substance not yet fully tested (EU).
    COUNTRY SPECIFIC INFORMATION
    Germany
    WGK: 3
    Self-Classification

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    16 - Other Information

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    WARRANTY
    The above information is believed to be correct but does not
    purport to be all inclusive and shall be used only as a guide. The
    information in this document is based on the present state of our
    knowledge and is applicable to the product with regard to
    appropriate safety precautions. It does not represent any
    guarantee of the properties of the product. Inc.,
    shall not be held liable for any damage resulting from handling or
    from contact with the above product. See reverse side of invoice
    or packing slip for additional terms and conditions of sale.
    Copyright 2010 Co. License granted to make
    unlimitedpaper copies for internal use only.
    DISCLAIMER
    For R&D use only. Not for drug, household or other uses.
    SIGMA        www.molbase.com    

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SECTION 16 - ADDITIONAL INFORMATION
N/A