五氧化二砷

五氧化二砷 基本信息
CAS号 1303-28-2 分子式 As2O5
分子量 229.84000 精确质量 　229.81800
PSA 　77.51000 LogP 　-1.30520
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目录
基本信息 制备方法与用途 物化性质 安全信息 毒性 MSDS 结构与计算数据

基本信息 展开↓

CAS号：
1303-28-2
分子式：
As2O5
分子量：
229.84000
中文名称：
五氧化二砷
英文名称：
ARSENIC PENTOXIDE
中文别名：
五氧化二砷;
无水砷酸;
氧化砷(V);
Indium monoarsenide;
arsanylidyneindium;
arsenic(-3) anion;
indium(+3) cation;
Bis(1,5-cyclooctadiene)nickel(0);
iron(2+) bis(5-carboxycyclopenta-1,3-dienide);
Ferrocenedicarboxylic acid;
1,1'-Ferrocenedicarboxylic acid;
dichlorozirconium;
dicyclopenta-1,3-dien-1-ylzirconium(2+) dichloride;
zirconium, di-1,3-cyclopentadien-1-yl-, chloride (1:2);
Cp2ZrCl2;
Bis(cyclopentadienyl)zirconium dichloride;
N-benzyl-7H-purin-6-amine;
N-benzyl-5H-purin-6-amine;
6-Benzylaminopurine;
iron(3+) 2-hydroxypropane-1,2,3-tricarboxylate ammoniate (1:1:1);
1,2,3-propanetricarboxylate, 2-hydroxy-, ammonium iron(3+) salt;
ammonium iron(2+) 2-hydroxypropane-1,2,3-tricarboxylate (1:1:1);
3-(carboxymethyl)-3-hydroxypentanedioic acid - iron (1:1) ammoniate;
Ammonium iron(Ⅲ)citrate;
Ammonium Ferric Citrate;
Ferric ammonium citrate, brown;
Dimethyl-pyridin-4-yl-amine;
Dimethyl-pyridin-4-yl-amine(DMAP);
N-(4-Pyridyl)dimethylamine;
4-Dimethylaminopyridine
英文别名：
ARSENIC PENTOXIDE;
Arsenic pentaoxide;
Caswell No. 057;
Arsenic anhydride;
Diarsenic pentaoxide;
Diarsenic pentoxide;
Arsenic acid anhydride;
Arsenic oxide As2O5
精确分子量/精确质量：
229.81800
极性分子表面积/PSA：
77.51000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
贝尔斯坦号/MDL：
MFCD00003434
EINECS：
215-116-9
PubChem：
24871878
InChI：
InChI=1/As4O10/c5-1-9-2(6)12-3(7,10-1)14-4(8,11-1)13-2

生产制备方法及用途展开↓

制备方法

将100g三氧化二砷装到圆底烧瓶里,加入100mL浓硝酸,然后加热。当不再产生棕色的氧化氮气体时,将溶液用倾析法转移到别的烧瓶中,再加50mL浓硝酸并加热,在300℃以下蒸干。蒸发剩余物用尽可能少的水浸湿并溶解。用玻璃过滤器过滤后,在250～300℃加热逐渐地脱水:如果温度过高,就放出氧气而分解,变成三氧化二砷,因此必须注意。随着脱水的进行,出现白色粉末状剩余物,完全固化之后,放在装有五氧化二磷或浓硫酸的干燥器里保存。

合成制备方法

将100g三氧化二砷装到圆底烧瓶里，加入100mL浓硝酸，然后加热。当不再产生棕色的氧化氮气体时，将溶液用倾析法转移到别的烧瓶中，再加50mL浓硝酸并加热，在300℃以下蒸干。蒸发剩余物用尽可能少的水浸湿并溶解。用玻璃过滤器过滤后，在250～300℃加热逐渐地脱水：如果温度过高，就放出氧气而分解，变成三氧化二砷，因此必须注意。随着脱水的进行，出现白色粉末状剩余物，完全固化之后，放在装有五氧化二磷或浓硫酸的干燥器里保存。

用途简介

1.制备砷酸盐。制造有色玻璃。金属粘合剂。木材防腐。杀真菌剂。 2.用于制药物、杀虫剂、金属粘接剂、有色玻璃等。

用途

1.制备砷酸盐。制造有色玻璃。金属粘合剂。木材防腐。杀真菌剂。

2.用于制药物、杀虫剂、金属粘接剂、有色玻璃等。[16]

物化性质展开↓

外观与性状：
白色粉末
密度：
4.32
熔点：
315ºC
存储条件/存储方法：
库房通风低温干燥,与碱、酸类、食品添加剂分开存放
稳定性相关：

1.如果遵照规格使用和储存则不会分解，未有已知危险反应，避免酸、碱、卤素、卤素化合物。有潮解性，在315℃以上时分解为氧气及三氧化二砷。在水中溶解形成砷酸，将此溶液加热到130℃蒸发冷却时，则变为蜂蜜状有黏性的液体。将其放置在硫酸干燥器里，则得到美观而透明的H3AsO4·1/2H2O结晶。在-30℃放置几天之后，则生成H3AsO4·2H2O结晶。另外，将H3AsO4水溶液加热到175℃浓缩时，则生成As2O5·5/3H2O。As2O5也可溶解于酸、碱及乙醇。

2.稳定性[10]  稳定

3.禁配物[11]  酸类、卤素、水及水蒸气

4.避免接触的条件[12]   潮湿空气

5.聚合危害[13]   不聚合

6.分解产物[14]  氧化砷

其它信息：

1.性状：白色无定形固体，易潮解。[1]

2.熔点（℃）：315（分解）[2]

3.相对密度（水=1）：4.32[3]

4.溶解性：溶于水，溶于乙醇、酸、碱。[4]

安全信息展开↓

包装等级：
II
风险类别：
6.1
海关代码：
2811290010
危险类别码：
R23/25;R45;R50/53
安全说明：
S45-S53-S60-S61
安全标志：
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
S53:避免暴露——使用前先阅读专门的说明。
S60:本物质残余物和容器必须作为危险废物处理。
S61:避免排放到环境中。参考专门的说明/安全数据表。
危险标志：
T:Toxic;N:Dangerousfortheenvironment;

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CG2275000
CHEMICAL NAME :
Arsenic pentoxide
CAS REGISTRY NUMBER :
1303-28-2
LAST UPDATED :
199712
DATA ITEMS CITED :
45
MOLECULAR FORMULA :
As2-O5
MOLECULAR WEIGHT :
229.84
WISWESSER LINE NOTATION :
AS2 O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
55 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
12400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intratesticular
DOSE :
4597 ug/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
4597 ug/kg
SEX/DURATION :
male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Fibroblast
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 104,141,1982 *** REVIEWS *** ACGIH TLV-TWA 0.01 mg(As)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-Confirmed human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 23,39,1980 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 0.5 mg(As)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,16,1971 OSHA-cancer hazard CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1018,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.2 mg(As)/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.05 mg(As)/m3;Carcinogen JAN 1993 OEL-BELGIUM:TWA 0.2 mg(As)/m3 JAN 1993 OEL-DENMARK:TWA 0.05 mg(As)/m3 JAN 1993 OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.2 mg(As)/m3 JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-HUNGARY:STEL 0.5 mg(As)/m3;Carcinogen JAN 1993 OEL-INDIA:TWA 0.2 mg(As)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.5 mg(As)/m3 JAN 1993 OEL-POLAND:TWA 0.3 mg(As)/m3 JAN 1993 OEL-SWEDEN:TWA 0.03 mg(As)/m3;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg(As)/m3;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg/m3;Skin JAN 1993 OEL-THAILAND:TWA 0.5 mg(As)/m3 JAN 1993 OEL-TURKEY:TWA 0.5 mg(As)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.2 mg(As)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.2 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ARSENIC, INORGANIC-air:CA CL 0.002 mg(As)/m3/15M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84436 No. of Facilities: 174 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1744 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84436 No. of Facilities: 457 (estimated) No. of Industries: 7 No. of Occupations: 11 No. of Employees: 14394 (estimated) No. of Female Employees: 5393 (estimated)
毒理学数据：

1.急性毒性[5]

LD50：8mg/kg（大鼠经口）；55mg/kg（小鼠经口）

2.刺激性  暂无资料

3.致突变性[6]  DNA修复：枯草菌50mmol/L。细胞遗传学分析：人白细胞1200nmol/L。DNA抑制：人成纤维细胞100μmol/L。姐妹染色单体交换：仓鼠成纤维细胞3200μg/L。

4.致癌性[7]  IARC致癌性评论：IARC将砷及其无机化合物列为G1，确认人类致癌物。

5.其他[8]  小鼠皮下注射最低中毒剂量（TDLo）：4597μg/kg（30d，雄性），对睾丸、附睾和输精管产生影响。

生态数据：

1.生态毒性[9]

LC50：0.01mg/L（96h）（鱼）

EC50：1.4mg/L（3周）（水蚤）

2.生物降解性   暂无资料

3.非生物降解性  暂无资料

MSDS 展开↓

Name: Arsenic(V) oxide 99.9+% Material Safety Data Sheet
Synonym: Arsenic pentoxid
CAS: 1303-28-2
Section 1 - Chemical Product   MSDS Name:Arsenic(V) oxide 99.9+% Material Safety Data Sheet
Synonym:Arsenic pentoxid
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
1303-28-2 Arsenic(V) oxide 99.9+% 215-116-9
Hazard Symbols: T N
Risk Phrases: 23/25 45 50/53
Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Toxic by inhalation and if swallowed. May cause cancer. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.Moisture sensitive.
Potential Health Effects
Eye:
May cause conjunctivitis. May cause eye irritation and possible burns.
Skin:
May cause irritation with burning pain, itching and redness. May cause dermatitis.
Ingestion:
May be fatal if swallowed. May cause liver damage. May cause cardiac disturbances. May cause severe digestive tract irritation with abdominal pain, nausea, vomiting and diarrhea. May cause central nervous system effects.
Inhalation:
May cause ulceration and perforation of the nasal septum if inhaled in excessive quantities. May cause chemical bronchitis with coughing and difficulty in breathing. Toxic if inhaled.
Chronic:
Prolonged or repeated inhalation may cause kidney and lung damage.
Chronic ingestion may cause liver damage. Prolonged or repeated skin contact may cause dermatitis. May cause bone marrow abnormalities with damage to blood forming tissues. Chronic inhalation may cause nasal septum ulceration and perforation. Repeated exposure may cause kidney damage and digestive tract abnormalities. Repeated exposure may cause central nervous system damage.
Section 4 - FIRST AID MEASURES
  Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Substance is noncombustible.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.
Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions.
Section 7 - HANDLING and STORAGE
  Handling:
Use only in a well-ventilated area. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Poison room locked.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 1303-28-2: United Kingdom, MEL - TWA: (listed as arsenic compounds, n.o.s.): mg/m3 TWA (as As, except arsine) United States OSHA: 5 g/m3 Action Level (as As); 10 g/m3 PEL (a As. Cancer hazard - see 29 CFR 1 910.1018. Arsine excepted) (listed under Arsenic, inorganic compounds).
Belgium - TWA: (listed as arsenic, inorganic compounds): 0.01 mg/ VLE (as As) Germany: 0.1 mg/m3 TWA (inhalable fraction) Japan: (listed as arsenic compounds, n.o.s.): 3 g/m3 OEL (refere value, as As) Malaysia: (listed as arsenic, inorganic compounds): 0.01 mg/m3 TW (as As, except arsine) Netherlands: (listed as arsenic, inorganic compounds): 0.1 mg/m3 (as As) Netherlands: (listed as arsenic, inorganic compounds): 0.050 mg/m MAC (as As) Russia: (listed as arsenic, inorganic compounds): 0.04 mg/m3 TWA As) Russia: (listed as arsenic, inorganic compounds): 0.01 mg/m3 STEL As) Spain: (listed as arsenic, inorganic compounds): 0.1 mg/m3 VLA-ED As) Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 315 deg C(decom)
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: 150 g/100ml water (19C)
Specific Gravity/Density:
Molecular Formula: As2O5
Molecular Weight: 229.84
Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
High temperatures, incompatible materials, exposure to moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases, active metals, halogens.
Hazardous Decomposition Products:
Oxides of arsenic, arsine.
Hazardous Polymerization: Will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 1303-28-2: CG2275000 LD50/LC50:
CAS# 1303-28-2: Oral, mouse: LD50 = 55 mg/kg; Oral, rat: LD50 = 8 mg/kg.
Carcinogenicity:
Arsenic(V) oxide - California: carcinogen, initial date 2/27/87 (listed as Arsenic, inorg NTP: Known carcinogen (listed as Arsenic, inorganic compounds).
IARC: Group 1 carcinogen (listed as Arsenic compounds, n.o.s.).
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
 
Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: ARSENIC COMPOUND, SOLID, N.O.S.
Hazard Class: 6.1
UN Number: 1557
Packing Group: II
IMO
Shipping Name: ARSENIC COMPOUND, SOLID, N.O.S.
Hazard Class: 6.1
UN Number: 1557
Packing Group: II
RID/ADR
Shipping Name: ARSENIC COMPOUND, SOLID, N.O.S.
Hazard Class: 6.1
UN Number: 1557
Packing group: II
USA RQ: CAS# 1303-28-2: 1 lb final RQ; 0.454 kg final RQ
Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T N
Risk Phrases:
R 45 May cause cancer.
R 23/25 Toxic by inhalation and if swallowed.
R 50/53 Very toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 60 This material and its container must be
disposed of as hazardous waste.
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 1303-28-2: 3
Canada
CAS# 1303-28-2 is listed on Canada's DSL List.
CAS# 1303-28-2 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1303-28-2 is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION
N/A

分子结构与计算化学数据展开↓

分子结构数据

1、摩尔折射率：无可用的

2、摩尔体积（cm3/mol）：无可用的

3、等张比容（90.2K）：无可用的

4、表面张力（dyne/cm）：无可用的

5、介电常数：无可用的

6、极化率（10-24cm3）：无可用的

7、单一同位素质量：229.817767 Da

8、标称质量：230 Da

9、平均质量：229.8402 Da

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:0

3.氢键受体数量:5

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积77.5

7.重原子数量:7

8.表面电荷:0

9.复杂度:124

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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