左旋伪麻黄碱

左旋伪麻黄碱 基本信息
CAS号 321-97-1 分子式 C10H15NO
分子量 165.23200 精确质量 　165.11500
PSA 　32.26000 LogP 　1.71880
我要卖该产品 我要采购该产品

等价的CAS号：

90-82-4,299-42-3,321-97-1,321-98-2,4125-58-0,34783-90-9,38732-95-5,53214-57-6,90-81-3
充值推广 查看更多供应商
目录
基本信息 制备方法与用途 物化性质 安全信息 毒性 MSDS 海关数据 结构与计算数据 上下游

基本信息 展开↓

CAS号：
321-97-1
3D弹球模型：
立即前往扯扯看
分子式：
C10H15NO
分子量：
165.23200
中文名称：
左旋伪麻黄碱
英文名称：
(-)-Pseudoephedrine
中文别名：
左旋伪麻黄碱;
R,R(-)-伪麻黄碱
英文别名：
(-)-Pseudoephedrine;
l-Pseudoephedrine base;
(-)-threo-Ephedrine;
CPDD 0049;
PSEUDOEPHEDRINE BASE;
(-)-y-Ephedrine;
R,R(-)-PSEUDOEPHEDRINE;
(1r,2r)-ephedrine;
S,S(+)-Pseudoephedrine
精确分子量/精确质量：
165.11500
极性分子表面积/PSA：
32.26000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
贝尔斯坦号/MDL：
MFCD00002203
EINECS：
206-292-8
PubChem：
24857283
BRN：
2803417
InChI：
The Key: KWGRBVOPPLSCSI-WCBMZHEXSA-N

生产制备方法及用途展开↓

制备方法

呼吸系统用药。

用途简介

用途

呼吸系统用药。

物化性质展开↓

外观与性状：
白色至近乎于白色结晶粉末
密度：
1.015 g/cm3
熔点：
118-120 °C(lit.)
沸点：
255ºC at 760 mmHg
闪点：
85.6ºC
存储条件/存储方法：

密封储存，储存于阴凉、干燥的库房。避免阳光直射。

稳定性相关：

常温常压下稳定，避免与氧化剂接触。

与氧化剂反应。

 

其它信息：

1.       性状：白色晶体或结晶状粉末

2.       密度（g/mL,25℃）：未确定

3.       相对蒸汽密度（g/mL,空气=1）：未确定

4.       熔点（ºC）：118-120

5.       沸点（ºC,常压）：266

6.       沸点（ºC,18mmHg）：未确定

7.       折射率(n20/D)：未确定

8.       闪点（ºF）：未确定

9.       比旋光度（º）：-51

10.    自燃点或引燃温度（ºC）：未确定

11.    蒸气压（mmHg,25ºC）：未确定

12.    饱和蒸气压（kPa,83-85ºC）：未确定

13.    燃烧热（KJ/mol）：未确定

14.    临界温度（ºC）：未确定

15.    临界压力（KPa）：未确定

16.    油水（辛醇/水）分配系数的对数值：未确定

17.    爆炸上限（%,V/V）：未确定

18.    爆炸下限（%,V/V）：未确定

19.    溶解性：未确定

安全信息展开↓

海关代码：
2922199090
WGK_Germany：
3
德国有关水污染物质的分类清单
危险类别码：
R20/21/22;R36/37/38
安全说明：
S26-S37/39
RTECS号：
UL5750500
安全标志：
S26:万一接触眼睛，立即使用大量清水冲洗并送医诊治。
:
危险标志：
Xn:Harmful;

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UL5750500
CHEMICAL NAME :
Pseudoephedrine, (-)-
CAS REGISTRY NUMBER :
321-97-1
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C10-H15-N-O
MOLECULAR WEIGHT :
165.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
248 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,987,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
105 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 148,158,1965
毒理学数据：

1、急性毒性：小鼠经口LD50：248mg/kg；小鼠经静脉LD50：105mg/kg；

MSDS 展开↓

Name: (1R 2R)-(-)-Pseudoephedrine Material Safety Data Sheet
Synonym: Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, (R-(R*,R*))-; (1R,2R)-Ephedrine; (-)-Pseudoephedrine; D-Pseudoephedrine; L-Pseudoephedrine
CAS: 321-97-1
Section 1 - Chemical Product   MSDS Name:(1R 2R)-(-)-Pseudoephedrine Material Safety Data Sheet
Synonym:Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, (R-(R*,R*))-; (1R,2R)-Ephedrine; (-)-Pseudoephedrine; D-Pseudoephedrine; L-Pseudoephedrine
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
321-97-1 (1R,2R)-(-)-Pseudoephedrine ca 100 206-292-8
Hazard Symbols: None Listed.
Risk Phrases: None Listed.
Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Light sensitive.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.
Section 4 - FIRST AID MEASURES
  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.
Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 321-97-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Crystalline powder
Color: white
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 117.00 - 118.00 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: slightly soluble in water
Specific Gravity/Density:
Molecular Formula: C10H15NO
Molecular Weight: 165.23
Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, light, dust generation, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported
Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 321-97-1: UL5750500 LD50/LC50:
Not available.
Carcinogenicity:
(1R,2R)-(-)-Pseudoephedrine - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
 
Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
 
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.
Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 321-97-1: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 321-97-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 321-97-1 is not listed on the TSCA inventory.
It is for research and development use only.

SECTION 16 - ADDITIONAL INFORMATION
N/A

海关数据查看详细

中国海关编码：2922199090

概述：
2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素：
品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
摘要/Summary：
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

分子结构与计算化学数据展开↓

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:2

3.氢键受体数量:2

4.可旋转化学键数量:3

5.互变异构体数量:无

6.拓扑分子极性表面积32.3

7.重原子数量:12

8.表面电荷:0

9.复杂度:121

10.同位素原子数量:0

11.确定原子立构中心数量:2

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

上下游相关产品

下游产品

更多

  • 225938-47-6

    (2S)-氨基-n-[(1r,2r)-2-羟基-1-甲基-2-苯基乙基]-n-甲基-4-戊酰胺

  • 192060-67-6

    丙酰胺, N-[(1R,2R)-2-羟基-1-甲基-2-苯基乙基]-N-甲基-

  • 6380-23-0

    3,4-二甲氧基苯乙烯

  • 130459-44-8

    (-)-(1R,2R)-N-(3,4-dimethoxyphenethyl)pseudoephedrine

  • 170115-98-7

    2-氨基-n-((1r,2r)-1-羟基-1-苯基-2-丙基)-n-甲基乙酰胺

立即下载安装“化学加”APP
专业、功能强大，随时调用更加方便
下载APP