| 西他列汀 基本信息 | |||
|---|---|---|---|
| CAS号 | 486460-32-6 | 分子式 | C16H15F6N5O |
| 分子量 | 407.31400 | 精确质量 | 407.11800 |
| PSA | N/A | LogP | N/A |
合成路线 共1页 1169707-28-1
7-(1-oxo-3((R)-amino)-4-(2,4,5-trifluorophenyl)butyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine di-p-tolyl-L-tartarate
→
~99%
486460-32-6
西他列汀
1242069-63-1
(R)-benzyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
→
~99%
486460-32-6
西他列汀
767340-03-4
(2Z)-4-氧代-4-[3-(三氟甲基)-5,6-二氢-[1,2,4]三唑并[4,3-a]吡嗪-7(8H)-基]-1-(2,4,5-三氟苯基)丁-2-烯-2-胺
→
~98%
486460-32-6
西他列汀
486460-23-5
叔丁氧羰基-西他列汀
→
~98%
486460-32-6
西他列汀
1380521-88-9
(R,R)-N-benzyl-N-(α-methylbenzyl)-1-(2',4',5'-trifluorophenyl)-4-oxo-4-{3''-(trifluoromethyl)-5'',6''-dihydro-1'',2'',4''-triazolo[4,3-α]pyrazin-7''(8''H)-yl}butan-2-amine
→
~97%
486460-32-6
西他列汀
1169707-30-5
(3R)-1-[5,6-二氢-3-(三氟甲基)-1,2,4-三唑并[4,3-a]吡嗪-7(8H)-基]-3-[[(1R)-1-苯乙基]氨基]-4-(2,4,5-三氟苯基)-1-丁酮
→
~94%
486460-32-6
西他列汀
823817-58-9
ent-Sitagliptin Phosphate
→
~93%
486460-32-6
西他列汀
764667-65-4
(2Z)-4-氧代-4-[3-(三氟甲基)-5,6-二氢-[1,2,4]三唑并[4,3-a]吡嗪-7-(8H)-基]-1-(2,4,5-三氟苯基)丁-2-酮
→
~92%
486460-32-6
西他列汀
1393363-87-5
(R)-N-benzyl-1-(2',4',5'-trifluorophenyl)-4-oxo-4-{3''-(trifluoromethyl)-5'',6''-dihydro-1'',2'',4''-triazolo[4,3-α]pyrazin-7''(8''H)-yl}butan-2-amine
→
~88%
486460-32-6
西他列汀
1253055-98-9
(R)-3-azido-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
→
~87%
486460-32-6
西他列汀
1351564-29-8
(R)-3-nitro-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
→
~85%
486460-32-6
西他列汀
1361389-75-4
1361389-75-4
→
~84%
486460-32-6
西他列汀
1404380-73-9
(S)-benzyl (1,4-dioxo-4-(3-(trifluoromethyl)-5,6,7,8-tetra hydro-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
→
~57%
486460-32-6
西他列汀
327-52-6
2,4,5-三氟溴苯
+
1404380-72-8
(S)-benzyl (1-(methoxy(methyl)amino)-1,4-dioxo-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)butan-2-yl)carbamate
→
486460-32-6
西他列汀
1352613-31-0
(S)-3-(methanesulfonyloxy)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
→
486460-32-6
西他列汀
767352-30-7
(4R)-1-苯甲氧基-4-[(2,4,5-三氟苯基)甲基]-2-氮杂环丁酮
→
486460-32-6
西他列汀
1048703-14-5
(R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
→
486460-32-6
西他列汀
1380243-41-3
(R)-N-benzyl-4-(benzyloxy)-1-(2,4,5-trifluorophenyl)butan-2-amine
→
486460-32-6
西他列汀
1380243-39-9
(R)-tert-butyl (4-(benzyloxy)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
→
486460-32-6
西他列汀
1380243-37-7
(R)-tert-butyl (4-(methoxymethoxy)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
→
486460-32-6
西他列汀
1380243-35-5
1380243-35-5
→
486460-32-6
西他列汀
1380243-28-6
1380243-28-6
→
486460-32-6
西他列汀
1152439-74-1
ethyl (R)-3-tert-butoxycarbonylamino-4-(2,4,5-trifluoro-phenyl)-butyrate
→
486460-32-6
西他列汀
1433545-80-2
(S)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-yl p-toluenesulfonate
→
486460-32-6
西他列汀
1404380-75-1
(S)-3-((benzyloxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)-4-oxobutanoic acid methyl ester
→
486460-32-6
西他列汀
1380521-87-8
1380521-87-8
→
486460-32-6
西他列汀
1380521-86-7
tert-butyl (R,R)-3-[N-benzyl-N-(α-methyl-p-methoxybenzyl)amino]-4-(2',4',5'-trifluorophenyl)butanoate
→
486460-32-6
西他列汀
1380521-85-6
tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(2',4',5'-trifluorophenyl)butanoate
→
486460-32-6
西他列汀
1253055-94-5
1253055-94-5
→
486460-32-6
西他列汀
881995-69-3
西他列汀-int A8
→
486460-32-6
西他列汀
881995-70-6
西他列汀-int A3
→
486460-32-6
西他列汀
764667-64-3
5-[1-羟基-2-(2,4,5-三氟苯基)亚乙基]-2,2-二甲基-1,3-二氧六环-4,6-二酮
→
486460-32-6
西他列汀
1329036-54-5
1329036-54-5
→
486460-32-6
西他列汀
1329036-44-3
(3R)-3-azido-(2,4,5-trifluorophenyl)butyric acid (R)-methylbenzylamine salt
→
486460-32-6
西他列汀
1329036-41-0
1329036-41-0
→
486460-32-6
西他列汀
1293293-73-8
(3R)-3-azido-4-(2,4,5-trifluorophenyl)-butyric acid
→
486460-32-6
西他列汀
1169707-29-2
(2Z)-3-{[(1R)-1-Phenylethyl]amino}-1-[3-(trifluoromethyl)-5,6-dih ydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophe nyl)-2-buten-1-one
→
486460-32-6
西他列汀
769195-26-8
3-氧代-4-(2,4,5-三氟苯基)丁酸甲酯
→
486460-32-6
西他列汀
1253055-92-3
3-氨基-4-(2,4,5-三氟苯基)丁酸甲酯
→
486460-32-6
西他列汀
1246960-25-7
(R)-3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid
→
486460-32-6
西他列汀
1352613-37-6
(S)-4-(methoxyamino)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl methane-sulfonate
→
486460-32-6
西他列汀
862156-85-2
L-tartaric acid (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
→
486460-32-6
西他列汀
486460-09-7
BOC-D-2,4,5-三氟苯丙氨酸
→
486460-32-6
西他列汀
486460-25-7
486460-25-7
→
486460-32-6
西他列汀
486460-07-5
(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2',4',5'-trifluorobenzyl)pyrazine
→
486460-32-6
西他列汀
486460-08-6
(R)-N-叔丁氧羰基-2,4,5-三氟苯胺甲酯
→
486460-32-6
西他列汀
486460-21-3
3-(三氟甲基)-5,6,7,8-四氢-[1,2,4]三唑并[4,3-a]吡嗪
→
486460-32-6
西他列汀
157911-56-3
2,4,5-三氟苄基溴
→
486460-32-6
西他列汀
1407666-67-4
(R)-4-(t-butoxy)-4-oxo-2-(2,4,5-trifluorobenzyl)butanoic acid
→
486460-32-6
西他列汀
1407666-61-8
(R)-t-butyl 4-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-3-(2,4,5-trifluorobenzyl)butanoate
→
486460-32-6
西他列汀
651047-33-5
3-(2,4,5-三氟苯基)丙酸
→
486460-32-6
西他列汀
1352613-29-6
(S)-ethyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate
→
486460-32-6
西他列汀
1352613-36-5
(S)-3-hydroxy-N-methoxy-4-(2,4,5-trifluorophenyl)butanamide
→
486460-32-6
西他列汀
1283096-74-1
(S)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanenitrile
→
486460-32-6
西他列汀
1293293-71-6
(2R)-1-(2,4,5-trifluorophenyl)-4-pentene-2-ol
→
486460-32-6
西他列汀
1293293-72-7
(2S)-1-(2-azido-4-pentenyl)-2,4,5-trifluorobenzene
→
486460-32-6
西他列汀
1283096-72-9
(2S)-2-(2,4,5-trifluorobenzyl)-oxirane
→
486460-32-6
西他列汀
868071-17-4
(3S)-2’,4’,5’-三氟-3-羟基苯丁酸
→
486460-32-6
西他列汀
1352613-30-9
(S)-3-hydroxy-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
→
486460-32-6
西他列汀
209995-38-0
2,4,5-三氟苯乙酸
→
486460-32-6
西他列汀
1246960-15-5
1246960-15-5
→
486460-32-6
西他列汀
486460-20-2
3-三氟甲基-1,2,4-三唑并[4,3-a]吡嗪
→
486460-32-6
西他列汀
327-52-6
2,4,5-三氟溴苯
→
486460-32-6
西他列汀
486460-00-8
(3R)-N-叔丁氧羰基-3-氨基-4-(2,4,5-三氟苯基)丁酸
→
486460-32-6
西他列汀
862156-85-2
L-tartaric acid (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
+
1219440-28-4
L-tartaric acid (2S)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
→
486460-32-6
西他列汀
1190094-97-3
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine (-)dibenzolyl-L-tartaric acid salt
→
486460-32-6
西他列汀
1253056-10-8
(R)-2-(4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)isoindoline-1,3-dione
→
486460-32-6
西他列汀
1253056-00-6
(R)-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl methanesulfonate
→
486460-32-6
西他列汀
823817-56-7
西他列汀-A
→
486460-32-6
西他列汀
1259320-67-6
2-(R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]-7(8H)-pyrazinyl]-1-(2,4,5-trifluorophenyl)-2-butanamine dodecylthio carbamate
→
486460-32-6
西他列汀
847445-81-2
3-氨基-1-[5,6-二氢-3-(三氟甲基)-1,2,4-噻唑并[4,3-a]吡嗪-7(8H)-基]-4-(2,4,5-三氟苯基)-2-丁烯-1-酮
→
486460-32-6
西他列汀
1352613-41-2
(R)-3-(methoxyamino)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
→
486460-32-6
西他列汀