酚磺乙胺

酚磺乙胺 基本信息
CAS号 2624-44-4 分子式 C10H17NO5S
分子量 263.31100 精确质量 　263.08300
PSA 　115.24000 LogP 　2.43200
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目录
基本信息 制备方法与用途 物化性质 安全信息 毒性 海关数据

基本信息 展开↓

CAS号：
2624-44-4
3D弹球模型：
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分子式：
C10H17NO5S
分子量：
263.31100
中文名称：
酚磺乙胺
英文名称：
2,5-Dihydroxybenzenesulfonic acid N-ethylethanamine (1:1)
中文别名：
酚磺乙胺;
二乙胺2,5-二羟基苯磺酸盐;
异戊酰胺.异丙基乙酰胺
英文别名：
2,5-Dihydroxybenzenesulfonic acid N-ethylethanamine (1:1);
Benzenesulfonic acid,2,5-dihydroxy-,compd. with N-ethylethanamine;
Diethylamine 2,5-Dihydroxybenzenesulfonate;
2,5-Dihydroxybenzenesulfonic acid - N-ethylethanamine (1:1);
Ethamsylate
精确分子量/精确质量：
263.08300
极性分子表面积/PSA：
115.24000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
EINECS：
220-090-7
InChI：
InChI=1/C6H6O5S.C4H11N/c7-4-1-2-5(8)6(3-4)12(9,10)11;1-3-5-4-2/h1-3,7-8H,(H,9,10,11);5H,3-4H2,1-2H3

生产制备方法及用途展开↓

制备方法

由二乙胺用二氧化硫成盐后与对苯二醌加成而得。将二乙胺、乙醇和水加入反应锅内,冷至0℃,通入二氧化硫至反应液pH=3.5-4为止,反应温度控制在10℃以下,得二乙胺亚硫酸盐溶液。然后,于0-10℃缓缓加入对苯二醌。加毕,减压回收乙醇,冷却结晶,过滤。结晶加蒸馏水加热溶解,用活性炭脱色精制,即得酚磺乙胺成品。

用途简介

用于手术前预防。

物化性质展开↓

外观与性状：
白色晶体或结晶粉末
熔点：
127-131ºC
沸点：
496.4ºC at 760 mmHg
闪点：
254ºC
蒸汽压：
1.13E-10mmHg at 25°C

安全信息展开↓

海关代码：
2921199090

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DB6145000
CHEMICAL NAME :
Benzenesulfonic acid, 2,5-dihydroxy-, compd. with diethylamine
CAS REGISTRY NUMBER :
2624-44-4
LAST UPDATED :
199806
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C6-H6-O5-S.C4-H11-N
MOLECULAR WEIGHT :
263.34
WISWESSER LINE NOTATION :
WSQR BQ EQ &2M2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>4 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
29750 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - excitement
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6040 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
760 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
3500 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - excitement

MUTATION DATA

TYPE OF TEST :
Sex chromosome loss and nondisjunction
TEST SYSTEM :
Mold - Aspergillus nidulans
DOSE/DURATION :
1 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,159,1974

海关数据查看详细

中国海关编码：2921199090

概述：
2921199090 其他无环单胺及其衍生物及其盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%
申报要素：
品名, 成分含量, 用途
摘要/Summary：
2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
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