(S,S,S)-2-氮杂双环[3,3,0]辛烷-3-羧酸苄酯盐酸盐

(S,S,S)-2-氮杂双环[3,3,0]辛烷-3-羧酸苄酯盐酸盐 基本信息
CAS号 637-23-0 分子式 C15H20ClNO2
分子量 281.77800 精确质量 　281.11800
PSA 　29.54000 LogP 　3.20850
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目录
基本信息 制备方法与用途 物化性质 安全信息 合成路线 毒性 海关数据 上下游

基本信息 展开↓

CAS号：
637-23-0
3D弹球模型：
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分子式：
C15H20ClNO2
分子量：
281.77800
中文名称：
(S,S,S)-2-氮杂双环[3,3,0]辛烷-3-羧酸苄酯盐酸盐
英文名称：
tropacocaine hydrochloride
中文别名：
(S,S,S)-2-氮杂双环[3,3,0]辛烷-3-羧酸苄酯盐酸盐;
Homatropine HCl;
8-methyl-8-azabicyclo[3.2.1]oct-3-yl hydroxy(phenyl)acetate hydrochloride (1:1);
aluminum salt;
Aluminium tristearate;
aluminium (tri) stearate;
Aluminium stearate tech;
Aluminium stearate white powder;
aluminium octadecanoate;
octadecanoate, aluminum salt;
Aluminium stearate;
CCRIS 599;
HSDB 6002;
NCI-C02335;
RCRA waste number U222;
Toluene, 2-amino-, hydrochloride;
o-Aminotoluene hydrochloride;
o-Methylaniline hydrochloride;
o-Methylbenzenamine hydrochloride;
o-Toluidin hydrochloride;
o-Toluidine hydrochloride;
o-Toluidinium chloride;
o-Tolylamine hydrochloride;
ortho-Aminotoluene hydrochloride;
Benzenamine, 2-methyl-, hydrochloride (1:1);
o-Toluidine, hydrochloride;
RCRA waste no. U222;
2-methylaniline hydrochloride (1:1);
o-Tolidine hydroch;
N-Acetyl Cysteine;
N-acetylcysteine;
(2R)-2-(acetylamino)-3-sulfanylpropanoate;
N-Acetyl-cysteine;
N-Acetyl-L-cysteine
英文别名：
tropacocaine hydrochloride;
Benzoesaeure-tropan-3exo-ylester,Hydrochlorid;
endo-benzoic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester hydrochloride;
pseudotropine benzoate hydrochloride;
3exo-benzoyloxy-tropane,hydrochloride;
8-azabicyclo(3.2.1)octan-3-ol,8-methyl-,benzoate (ester),hydrochloride,ex benzoylpseudotropine hydrochloride;
Tropacaine hydrochloride;
Pseudotropin;
tropacocain hydrochloride;
3exo-Benzoyloxy-tropan,Hydrochlorid;
Tropacocaine (8-methyl-8-azabicyclo[3.2.1]oct-3-yl) benzoate
精确分子量/精确质量：
281.11800
极性分子表面积/PSA：
29.54000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
EINECS：
211-281-6
InChI：
InChI=1/C15H19NO2.ClH/c1-16-12-7-8-13(16)10-14(9-12)18-15(17)11-5-3-2-4-6-11;/h2-6,12-14H,7-10H2,1H3;1H

生产制备方法及用途展开↓

制备方法

用于合成雷米普利药物

用途简介

物化性质展开↓

沸点：
339.9ºC at 760 mmHg
闪点：
122.3ºC

安全信息展开↓

海关代码：
2933990090

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    (S,S,S)-2-氮杂双环[3,3,0]辛烷-3-羧酸苄酯盐酸盐

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YM4201000
CHEMICAL NAME :
1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, benzoate (ester), hydrochloride
CAS REGISTRY NUMBER :
637-23-0
LAST UPDATED :
198910
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C15-H19-N-O2.Cl-H
MOLECULAR WEIGHT :
281.81

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 7,227,1934
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
465 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RCSADO Research Communications in Substances Abuse. (PJD Pub. Ltd., P.O.Box 966, Westbury, NY 11590) V.1- 1980- Volume(issue)/page/year: 5,279,1984
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
42 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
REFERENCE :
WDMU** "Vergleichend-pharmakologische Untersuchungen ueber die haemolytische Wirkung und die Toxizitat der Lokalanaesthetika, Dissertation," Walther, M., Pharmakologischen Instit Martin Luther-Universitat Halle-Wittenburg, Ger. Dem. Rep., 1936 Volume(issue)/page/year: -,-,1936 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
120 mg/kg
SEX/DURATION :
female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
RCSADO Research Communications in Substances Abuse. (PJD Pub. Ltd., P.O.Box 966, Westbury, NY 11590) V.1- 1980- Volume(issue)/page/year: 5,279,1984

海关数据查看详细

中国海关编码：2933990090

概述：
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素：
品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
摘要/Summary：
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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