苄达明

苄达明 基本信息
CAS号 642-72-8 分子式 C19H23N3O
分子量 309.40500 精确质量 　309.18400
PSA 　30.29000 LogP 　3.41510
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目录
基本信息 物化性质 安全信息 毒性 海关数据 上下游

基本信息 展开↓

CAS号：
642-72-8
3D弹球模型：
立即前往扯扯看
分子式：
C19H23N3O
分子量：
309.40500
中文名称：
苄达明
英文名称：
3-(1-benzylindazol-3-yl)oxy-N,N-dimethylpropan-1-amine
中文别名：
苄达明;
1-苄基-3-[3-(二甲基氨基)丙氧基]-1H-吲唑
英文别名：
3-(1-benzylindazol-3-yl)oxy-N,N-dimethylpropan-1-amine;
Benzydaminum [INN-Latin];
Benzydamine [INN:BAN];
1H-Indazole,1-benzyl-3-(3-(dimethylamino)propoxy);
Bencidamina [INN-Spanish];
benzidamine;
Benzidamina [DCIT];
EINECS 211-388-8;
C 1523;
Benzydamine;
[3-(1-benzyl-1H-indazol-3-yloxy)-propyl]-dimethyl-amine
精确分子量/精确质量：
309.18400
极性分子表面积/PSA：
30.29000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
EINECS：
211-388-8
InChI：
InChI=1/C19H23N3O/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16/h3-7,9-12H,8,13-15H2,1-2H3

物化性质展开↓

密度：
1.08g/cm3
沸点：
474.4ºC at 760 mmHg
闪点：
240.7ºC
折射率：
1.579
存储条件/存储方法：
通风低温干燥,与库房食品原料分开存放

安全信息展开↓

海关代码：
2933990090

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NK7790000
CHEMICAL NAME :
1H-Indazole, 1-benzyl-3-(3-(dimethylamino)propoxy)-
CAS REGISTRY NUMBER :
642-72-8
BEILSTEIN REFERENCE NO. :
0896536
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C19-H23-N3-O
MOLECULAR WEIGHT :
309.45
WISWESSER LINE NOTATION :
T56 BNNJ B1R& DO3N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
950 mg/kg
TOXIC EFFECTS :
Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 15,41,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
460 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,1266,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
109 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 15,471,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
445 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1285,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1285,1972 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8925 mg/kg/21D-I
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Related to Chronic Data - changes in testicular weight
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 22,226,1972

海关数据查看详细

中国海关编码：2933990090

概述：
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素：
品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
摘要/Summary：
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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