盐酸平阳霉素

盐酸平阳霉素 基本信息
CAS号 55658-47-4 分子式 C57H90ClN19O21S2
分子量 1477.02000 精确质量 　1475.57000
PSA 　721.60000 LogP 　-0.63200
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目录
基本信息 物化性质 毒性

基本信息 展开↓

CAS号：
55658-47-4
分子式：
C57H90ClN19O21S2
分子量：
1477.02000
中文名称：
盐酸平阳霉素
英文名称：
BLEOCIN(TM), STREPTOMYCES VERTICILLUS
中文别名：
盐酸平阳霉素;
(S,R)-1-(1-dimethylaminoethyl)-1,2-*bis(diphenyl;
1,2,3,4,5-cyclopentanepentayl, 1-[(1S)-1-(dimethylamino)ethyl]-2-(diphenylphosphino)-, compd. with 1-(diphenylphosphino)-1,2,3,4,5-cyclopentanepentayl, iron salt (1:1:1);
(S)-N,N-Dimethyl-1-[(R)-1',2-bis(diphenylphosphino)ferrocenyl]ethylamine;
(+)-(S)-N,N-dimethyl-1-((R)-2-(diphenyl-phosphino;
Tylmarin;
2-Propenoic acid, 3-(2-(acetyloxy)phenyl)- (9CI);
2-Acetoxycinnamic acid;
potassium salt of 6methyl-1,2,3-oxathiazine-4(3H)-one-2,2-dioxide;
acesulfame k fcciv;
potassium 6-methyl-1,2,3-oxathiazin-4-olate 2,2-dioxide;
Acesulfame Potassium
英文别名：
BLEOCIN(TM), STREPTOMYCES VERTICILLUS;
BLEOCIN(TM) ANTIBIOTIC;
n(sup1)-(3-((4-aminobutyl)amino)propyl)-bleomycinamidhydrochloride;
N1-[3-[(4-Aminobutyl)amino]propyl]bleomycinamide hydrochloride;
n(sup1)-(3-((4-aminobutyl)amino)propyl)bleomycinamidehydrochloride;
BleoMycin A5 Hydrochloride(PingyangMycin hydrochloride);
Bleomycin A5 Hydrochloride;
BLEOCIN(TM)
精确分子量/精确质量：
1475.57000
极性分子表面积/PSA：
721.60000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
InChI：
InChI=1/C57H89N19O21S2.ClH/c1-22-35(73-48(76-46(22)61)27(14-33(60)80)68-15-26(59)47(62)86)52(90)75-37(43(28-16-65-21-69-28)95-56-45(41(84)39(82)31(17-77)94-56)96-55-42(85)44(97-57(63)92)40(83)32(18-78)93-55)53(91)70-24(3)38(81)23(2)49(87)74-36(25(4)79)51(

物化性质展开↓

密度：
1.56g/cm3

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EC5990700
CHEMICAL NAME :
Bleomycinamide, N(sup 1)-(3-((4-aminobutyl)amino)propyl)-, hydrochloride
CAS REGISTRY NUMBER :
55658-47-4
LAST UPDATED :
199603
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C57-H89-N19-O21-S2.Cl-H
MOLECULAR WEIGHT :
1477.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
117 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
102 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
66 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
67 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,175,1979 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
40 mg/kg/8W-I
TOXIC EFFECTS :
Liver - changes in liver weight Blood - changes in other cell count (unspecified) Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,847,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
35 mg/kg/3W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - changes primarily in glomeruli
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,847,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
40 mg/kg/2W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - death
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,847,1979
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