CHEMICAL IDENTIFICATION

RTECS NUMBER :

TP2505900

CHEMICAL NAME :

Platinum, (2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine-N, N')(propanedioato(2-) -O,O')-, (SP-4-2-(4R-(2-alpha,4-alpha,5-beta)))-

CAS REGISTRY NUMBER :

146665-77-2

LAST UPDATED :

199509

DATA ITEMS CITED :

6

MOLECULAR FORMULA :

C11-H20-N2-O6-Pt

MOLECULAR WEIGHT :

471.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,205,1993

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

182 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,205,1993

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1590 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,205,1993

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

198 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,205,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

235 mg/kg/13W-I

TOXIC EFFECTS :

Blood - normocytic anemia Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,217,1992

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

15 mg/kg/90D-I

TOXIC EFFECTS :

Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Related to Chronic Data - death

REFERENCE :

KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,235,1992