甘珀酸

甘珀酸 基本信息
CAS号 5697-56-3 分子式 C34H50O7
分子量 570.75700 精确质量 　570.35600
PSA 　117.97000 LogP 　6.82830
我要卖该产品 我要采购该产品

等价的CAS号：

5697-56-3,14605-08-4
充值推广 查看更多供应商
目录
基本信息 制备方法与用途 物化性质 安全信息 毒性 MSDS 结构与计算数据

基本信息 展开↓

CAS号：
5697-56-3
3D弹球模型：
立即前往扯扯看
分子式：
C34H50O7
分子量：
570.75700
中文名称：
甘珀酸
英文名称：
Carbenoxolone
中文别名：
甘珀酸;
3-(3-羧基-1-氧代丙氧基)-11-氧代齐墩果-12-烯-29-甲酸;
p-Toluenesulfonylacetonitrile;
2-chloro-N-(tricyclo[3.3.1.1~3,7~]dec-1-yl)acetamide;
Ac-Gly-Gly-OH;
Z-Glutamic Acid-O Benzyl Ester;
(S)-2-Benzyloxycarbonylamino-pentanedioic acid 5-benzyl ester;
Cbz-L-glutamic acid 5-benzyl ester;
Cbz-Glu(OBzl)-OH;
Z-Glu(OBzl)-OH;
Glycine methyl ester hydrochloride Salt;
methyl glycinate hydrochloride (1:1);
2-methoxy-2-oxoethanaminium;
Glycine Methyl ester Hydrochoride;
Glycine Methylester Hydrochloride;
Glycine methyl ester hydrochloride;
BETANMETHASONE DIPROPIONATE;
BETAMETHASONEDIPROPIONATE,MICRONIZEDPOWDER,USP;
Diprophos;
Maxivate;
(11beta,16beta);
betamethasone 17,21-dipropionate;
pigment bordeaux perylene;
ponsol red yf;
variogen maroon 3920;
1,9-def:6,5,10-d'e'f')diisoquinoline-1,3,8,10(2h,9h)-tetrone,2,9-dimethyl-anthra;
vat red 23;
Anthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-1,3,8,10(2H,9H)-tetrone,2,9-dimethyl-;
2,9-dimethylisoquino[4',5',6':6,5,10]anthra[2,1,9-def]isoquinoline-1,3,8,10(2H,9H)-tetrone;
N,N'-dimethyl-3,4,9,10-perylenedicarboximide;
N,
英文别名：
Carbenoxolone;
bioral;
glycyrrhetinic acid hydrogen succinate;
2-Methylidene-2,3-dihydrofuran-3-one;
Carbenoxolon;
CARBENOXOLONE(RG);
biogastrone;
CARBENOXOLONE [U
精确分子量/精确质量：
570.35600
极性分子表面积/PSA：
117.97000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
EINECS：
227-174-2
InChI：
InChI=1/C34H50O7.2Na/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6;;/h18,21,23-24,27H,8-17,19H2,1-7H3,(H,36,37)(H,39,40);;/q;2*+1/p-2/t21-,23?,24-,27?,30+,31-,32-,33+,34+;

生产制备方法及用途展开↓

制备方法

产品具有抗菌、抗肿瘤及肾上腺皮质激素样作用，可制成抗炎抗过敏制剂，用于治疗风湿性关节炎、气喘，甘草次酸是经典的抗炎药物，将其应用于化妆品中可调节皮肤的免疫功能，增强皮肤的抗病能力，消除炎症、预防过敏。

用途简介

物化性质展开↓

外观与性状：
白色结晶粉末
密度：
1.20
熔点：
291-294 °C
沸点：
687.4ºC at 760 mmHg
闪点：
211.6ºC
存储条件/存储方法：
通风低温干燥
稳定性相关：

常温常压下稳定，具有抗菌、抗肿瘤及肾上腺皮质激素样作用，可制成抗炎抗过敏制剂，用于治疗风湿性关节炎、气喘，甘草次酸是经典的抗炎药物，将其应用于化妆品中可调节皮肤的免疫功能，增强皮肤的抗病能力，消除炎症、预防过敏。

安全信息展开↓

海关代码：
2938909030
WGK_Germany：
3
德国有关水污染物质的分类清单
危险类别码：
R36/37/38:Irritating to eyes, respiratory system and skin .
安全说明：
S26-S36-S37/39
危险标志：
Xi

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RK0200000
CHEMICAL NAME :
Olean-12-en-30-oic acid, 3-beta-hydroxy-11-oxo-, hydrogen succinate
CAS REGISTRY NUMBER :
5697-56-3
LAST UPDATED :
199712
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C34-H50-O7
MOLECULAR WEIGHT :
570.84
WISWESSER LINE NOTATION :
L F6 E6 B666 CV DUTJ A1 HVQ H1 K1 N1 O1 S1 S1 TOV2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
120 mg/kg/56D-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle weakness
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,150,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,323,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
128 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,323,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1720 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,323,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4224327
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
290 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4363816
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1060 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,323,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
371 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,323,1980 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
1313 mg/kg
SEX/DURATION :
female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
DBTGAJ Diabetologia. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1965- Volume(issue)/page/year: 39,1299,1996
毒理学数据：

1、急性毒性：

小鼠口服LD50：2450mg/kg，毒性作用的描述没有报告除此以外的其他致死剂量值。

生态数据：

燃烧产生刺激烟雾;药物副作用:肌肉无力,软弱无力,麻痹,瘫痪

MSDS 展开↓

  Material Safety Data Sheet
Section 1. Identification of the substance
    Product Name:      Carbenoxolone    
    Synonyms:
Section 2. Hazards identification
    Harmful by inhalation, in contact with skin, and if swallowed.
Section 3. Composition/information on ingredients.
    Ingredient name:        Carbenoxolone    
    CAS number:        5697-56-3    
Section 4. First aid measures
    Skin contact:        Immediately wash skin with copious amounts of water for at least 15 minutes while removing    
    contaminated clothing and shoes. If irritation persists, seek medical attention.
    Eye contact:        Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate    
    flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
    attention.
    Inhalation:        Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.    
    Ingestion:        Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.    
Section 5. Fire fighting measures
    In the event of a fire involving this material, alone or in combination with other materials, use dry
    powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
    should be worn.
Section 6. Accidental release measures
    Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
    standards.
    Respiratory precaution:        Wear approved mask/respirator    
    Hand precaution:        Wear suitable gloves/gauntlets    
    Skin protection:        Wear suitable protective clothing    
    Eye protection:        Wear suitable eye protection    
    Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
    for disposal. See section 12.
    Environmental precautions: Do not allow material to enter drains or water courses.
Section 7. Handling and storage
    Handling:        This product should be handled only by, or under the close supervision of, those properly qualified    
    in the handling and use of potentially hazardous chemicals, who should take into account the fire,
    health and chemical hazard data given on this sheet.
    Store in closed vessels, refrigerated.
    Storage:
Section 8. Exposure Controls / Personal protection
    Engineering Controls: Use only in a chemical fume hood.
    Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
    General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.
Section 9. Physical and chemical properties
    Appearance:        Not specified    
    Boiling point:        No data    
    No data
    Melting point:
    Flash point:        No data    
    Density:        No data    
    Molecular formula:        C34H50O7    
    Molecular weight:        570.8    
Section 10. Stability and reactivity
    Conditions to avoid: Heat, flames and sparks.
    Materials to avoid: Oxidizing agents.
    Possible hazardous combustion products: Carbon monoxide.
Section 11. Toxicological information
    No data.
Section 12. Ecological information
    No data.
Section 13. Disposal consideration
    Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
    disposal authority, in accordance with national and regional regulations.
Section 14. Transportation information
    Non-harzardous for air and ground transportation.
Section 15. Regulatory information
    No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
    302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
    Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

分子结构与计算化学数据展开↓

分子结构数据

1、   摩尔折射率：154.18

2、   摩尔体积（m3/mol）：475.4

3、   等张比容（90.2K）：1273.2

4、   表面张力（dyne/cm）：51.4

5、   极化率（10-24cm3）：61.12

计算化学数据

1、   疏水参数计算参考值（XlogP）：6.4

2、   氢键供体数量：2

3、   氢键受体数量：7

4、   可旋转化学键数量：6

5、   互变异构体数量：5

6、   拓扑分子极性表面积（TPSA）：118
7、   重原子数量：41

8、   表面电荷：0

9、   复杂度：1200

10、   同位素原子数量：0

11、   确定原子立构中心数量：9

12、   不确定原子立构中心数量：0

13、   确定化学键立构中心数量：0

14、   不确定化学键立构中心数量：0

15、   共价键单元数量：1

立即下载安装“化学加”APP
专业、功能强大，随时调用更加方便
下载APP