CAS号：

11070-73-8

分子式：

C254H377N65O75S6

分子量：

5733.53

中文名称：

重组人胰岛素

英文名称：

insulin from bovine pancreas

中文别名：

重组人胰岛素;
牛胰岛素;
(+-)-Demethylcoclaurine hydrochloride;
6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-, hydrochloride, (+-)-;
1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrochloride (1:1);
Higenamine HCl;
Norcoclaurine HCl;
Demethyl;
MK-135;
quantalan;
Questran;
cholestyramine resin;
Digitonin;
(3S)-3,6-diamino-N-{[(2S,5S,8E,11S,15S)-15-amino-11-[(4R)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentaazacyclohexadecan-5-yl]methyl}hexanamide - (3S)-3,6-diamino-N-({(2S;
3,6-diamino-N-{[(8Z)-15-amino-11-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentaazacyclohexadecan-5-yl]methyl}hexanamide sulfate (salt);
3,6-diamino-N-{[(8E)-15-amino-11-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12;
Capreomycin;
Copper oxyquinolate;
Copper quinolate;
Culinate;
Cunilate 2472;
Dokirin;
Dokivin;
Dorm

英文别名：

insulin from bovine pancreas;
insulin human;
insulin hybri-max from bovine pancreas;
insulin bovine;
Insulin (bovin);
Recombinant human insulin;
Human insulin,recombiannt from E.coli;
Demethyl;
MK-135;
quantalan;
Questran;
cholestyramine resin;
Digitonin;
(3S)-3,6-diamino-N-{[(2S,5S,8E,11S,15S)-15-amino-11-[(4R)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentaazacyclohexadecan-5-yl]methyl}hexanamide - (3S)-3,6-diamino-N-({(2S;
3,6-diamino-N-{[(8Z)-15-amino-11-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentaazacyclohexadecan-5-yl]methyl}hexanamide sulfate (salt);
3,6-diamino-N-{[(8E)-15-amino-11-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12;
Capreomycin;
Copper oxyquinolate;
Copper quinolate;
Culinate;
Cunilate 2472;
Dokirin;
Dokivin;
Dormycin;
Fruitdo;
Milmer;
Milmer 1;
Oxine-copper;
Copper 8-quinolinolate;
copper(2+) 8-

EINECS：

234-291-2

InChI：

InChI=1/C254H377N65O75S6/c1-29-131(24)205(312-192(334)103-256)250(389)317-204(130(22)23)246(385)287-158(74-81-199(344)345)216(355)281-155(70-77-188(260)330)220(359)307-183-116-399-400-117-184-242(381)305-177(110-321)238(377)293-161(87-122(6)7)223(362)294-

合成制备方法

从大肠杆菌产生胰岛素有两个途径，一是分别在大肠杆菌中合成Ａ链和Ｂ链，再在体外用化学方法连接两条肽链组成胰岛素；另一种方法是生产胰岛素原(Proinsulin)，即胰岛素前体，再用酶加工成胰岛素。用大肠杆菌生产的人胰岛素，每Ｌ发酵液可收获胰岛素40mg。