---

SECTION 1: Identification of the substance/mixture and of the company/undertaking
  Product identifiers
    Product name        : Hydroxylamine-15N hydrochloride    
    REACH No.        : A registration number is not available for this substance as the substance    
    or its uses are exempted from registration, the annual tonnage does not
    require a registration or the registration is envisaged for a later
    registration deadline.
    CAS-No.        : 40711-48-6    
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    
  
  

---

SECTION 2: Hazards identification
  Classification of the substance or mixture
  Classification according to Regulation (EC) No 1272/2008
    Corrosive to metals (Category 1), H290
    Acute toxicity, Oral (Category 4), H302
    Specific target organ toxicity - repeated exposure (Category 2), H373
    Eye irritation (Category 2), H319
    Skin irritation (Category 2), H315
    Skin sensitisation (Category 1), H317
    Acute aquatic toxicity (Category 1), H400
    Carcinogenicity (Category 2), H351
    Acute toxicity, Dermal (Category 4), H312
    For the full text of the H-Statements mentioned in this Section, see Section 16.
  Classification according to EU Directives 67/548/EEC or 1999/45/EC
    E Explosive        R2    
    R40
    Xn Harmful        R21/22, R48/22    
    Xi Irritant        R36/38    
    R43
    N Dangerous for the        R50    
    environment
    For the full text of the R-phrases mentioned in this Section, see Section 16.
  Label elements
  Labelling according Regulation (EC) No 1272/2008
    Pictogram
    Signal word        Warning    
    Hazard statement(s)
    H290        May be corrosive to metals.    
    H302        Harmful if swallowed.    
    H312        Harmful in contact with skin.    
    H315        Causes skin irritation.    
    H317        May cause an allergic skin reaction.    
    H319        Causes serious eye irritation.    
    H351        Suspected of causing cancer.    
    H373        May cause damage to organs through prolonged or repeated exposure.    
    H400        Very toxic to aquatic life.    
    Precautionary statement(s)
    P273        Avoid release to the environment.    
    P280        Wear protective gloves/ protective clothing.    
    P305 + P351 + P338        IF IN EYES: Rinse cautiously with water for several minutes. Remove    
    contact lenses, if present and easy to do. Continue rinsing.
    Supplemental Hazard        none    
    Statements
  Other hazards - none

---

SECTION 3: Composition/information on ingredients
  Substances
    Chemical characterization : Isotopically labeled
    Formula        : H315NO · HCl    
    Molecular Weight        : 70,48 g/mol    
    CAS-No.        : 40711-48-6    
  Hazardous ingredients according to Regulation (EC) No 1272/2008
    Component        Classification        Concentration    
  Hydroxylamine-15N hydrochloride
    Met. Corr. 1; Skin Irrit. 2; Eye        -    
    Irrit. 2; Skin Sens. 1; Carc. 2;
    STOT RE 2; Acute Tox. 4;
    Aquatic Acute 1; Acute Tox. 4;
    H319, H315, H373, H400,
    H290, H302, H312, H317,
    H351
  Hazardous ingredients according to Directive 1999/45/EC
    Component        Classification        Concentration    
  Hydroxylamine-15N hydrochloride
    E, Xn, N, Carc.Cat.3, R 2 -        -    
    R21/22 - R36/38 - R40 - R43 -
    R48/22 - R50
    For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

---

SECTION 4: First aid measures
  Description of first aid measures
  General advice
    Consult a physician. Show this safety data sheet to the doctor in attendance.
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
  In case of skin contact
    Wash off with soap and plenty of water. Consult a physician.
  In case of eye contact
    Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
  If swallowed
    Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
  Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
  Indication of any immediate medical attention and special treatment needed
    no data available

---

SECTION 5: Firefighting measures
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    nitrogen oxides (NOx)
  Advice for firefighters
    Wear self contained breathing apparatus for fire fighting if necessary.
  Further information
    no data available

---

SECTION 6: Accidental release measures
  Personal precautions, protective equipment and emergency procedures
    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure
    adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
    For personal protection see section 8.
  Environmental precautions
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
    environment must be avoided.
  Methods and materials for containment and cleaning up
    Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
    containers for disposal.
  Reference to other sections
    For disposal see section 13.

---

SECTION 7: Handling and storage
  Precautions for safe handling
    Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
    Provide appropriate exhaust ventilation at places where dust is formed.
    For precautions see section 2.2.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
    Store under inert gas. hygroscopic
  Specific end use(s)
    A part from the uses mentioned in section 1.2 no other specific uses are stipulated

---

SECTION 8: Exposure controls/personal protection
  Control parameters
  Components with workplace control parameters
  Exposure controls
  Appropriate engineering controls
    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
    at the end of workday.
  Personal protective equipment
  Eye/face protection
    Face shield and safety glasses Use equipment for eye protection tested and approved under
    appropriate government standards such as NIOSH (US) or EN 166(EU).
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
  Body Protection
    Complete suit protecting against chemicals, The type of protective equipment must be selected
    according to the concentration and amount of the dangerous substance at the specific workplace.
  Respiratory protection
    Where risk assessment shows air-purifying respirators are appropriate use a full-face particle
    respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering
    controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use
    respirators and components tested and approved under appropriate government standards such
    as NIOSH (US) or CEN (EU).
  Control of environmental exposure
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into
    the environment must be avoided.

---

SECTION 9: Physical and chemical properties
  Information on basic physical and chemical properties
    a) Appearance        Form: Fine crystals and fragments    
    Colour: white
    b) Odour        no data available    
    c) Odour Threshold        no data available    
    d) pH        no data available    
    e) Melting point/freezing        Melting point/range: 155 - 157 °C - lit.    
    point
    f) Initial boiling point and no data available
    boiling range
    g) Flash point        no data available    
    h) Evapouration rate        no data available    
    i) Flammability (solid, gas) no data available
    j) Upper/lower        no data available    
    flammability or
    explosive limits
    k) Vapour pressure        no data available    
    l) Vapour density        no data available    
    m) Relative density        no data available    
    n) Water solubility        no data available    
    o) Partition coefficient: n- no data available
    octanol/water
    p) Auto-ignition        no data available    
    temperature
    q) Decomposition        no data available    
    temperature
    r) Viscosity        no data available    
    s) Explosive properties        no data available    
    t) Oxidizing properties        no data available    
  Other safety information
    no data available

---

SECTION 10: Stability and reactivity
  Reactivity
    no data available
  Chemical stability
    Stable under recommended storage conditions.
  Possibility of hazardous reactions
    no data available
  Conditions to avoid
    Air
  Incompatible materials
    no data available
  Hazardous decomposition products
    Other decomposition products - no data available
    In the event of fire: see section 5

---

SECTION 11: Toxicological information
  Information on toxicological effects
  Acute toxicity
    no data available
  Skin corrosion/irritation
    no data available
  Serious eye damage/eye irritation
  Respiratory or skin sensitisation
    no data available
  Germ cell mutagenicity
  Carcinogenicity
    Limited evidence of carcinogenicity in animal studies
    IARC:        No component of this product present at levels greater than or equal to 0.1% is identified as    
    probable, possible or confirmed human carcinogen by IARC.
  Reproductive toxicity
  Specific target organ toxicity - single exposure
    no data available
  Specific target organ toxicity - repeated exposure
    no data available
  Aspiration hazard
    no data available
  Additional Information
    RTECS: Not available
    To the best of our knowledge, the chemical, physical, and toxicological properties have not been
    thoroughly investigated., Material is extremely destructive to tissue of the mucous membranes and upper
    respiratory tract, eyes, and skin., spasm, inflammation and edema of the larynx, spasm, inflammation and
    edema of the bronchi, pneumonitis, pulmonary edema, burning sensation, Cough, wheezing, laryngitis,
    Shortness of breath, Headache, Nausea, Vomiting, Absorption into the body leads to the formation of
    methemoglobin which in sufficient concentration causes cyanosis. Onset may be delayed 2 to 4 hours or
    longer., May cause convulsions.

---

SECTION 12: Ecological information
  Toxicity
    no data available
  Persistence and degradability
    no data available
  Bioaccumulative potential
    no data available
  Mobility in soil
    no data available
  Results of PBT and vPvB assessment
    PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
  Other adverse effects
    Very toxic to aquatic life.

---

SECTION 13: Disposal considerations
  Waste treatment methods
  Product
    Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material
    with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
  Contaminated packaging
    Dispose of as unused product.

---

SECTION 14: Transport information
  UN number
    ADR/RID: 2923        IMDG: 2923        IATA: 2923    
  UN proper shipping name
    ADR/RID: CORROSIVE SOLID, TOXIC, N.O.S. (Hydroxylamine-15N hydrochloride)
    IMDG: CORROSIVE SOLID, TOXIC, N.O.S. (Hydroxylamine-15N hydrochloride)
    IATA:        Corrosive solid, toxic, n.o.s. (Hydroxylamine-15N hydrochloride)    
  Transport hazard class(es)
    ADR/RID: 8 (6.1)        IMDG: 8 (6.1)        IATA: 8 (6.1)    
  Packaging group
    ADR/RID: II        IMDG: II        IATA: II    
  Environmental hazards
    ADR/RID: yes        IMDG Marine pollutant: yes        IATA: no    
  Special precautions for user
    no data available

---

SECTION 15: Regulatory information
    This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
  Safety, health and environmental regulations/legislation specific for the substance or mixture
    no data available
  Chemical Safety Assessment
    For this product a chemical safety assessment was not carried out

---

SECTION 16: Other information
  Full text of H-Statements referred to under sections 2 and 3.
    Acute Tox.        Acute toxicity    
    Aquatic Acute        Acute aquatic toxicity    
    Carc.        Carcinogenicity    
    Eye Irrit.        Eye irritation    
    H290        May be corrosive to metals.    
    H302        Harmful if swallowed.    
    H312        Harmful in contact with skin.    
    H315        Causes skin irritation.    
    H317        May cause an allergic skin reaction.    
    H319        Causes serious eye irritation.    
    H351        Suspected of causing cancer.    
    H373        May cause damage to organs through prolonged or repeated exposure.    
    H400        Very toxic to aquatic life.    
    Met. Corr.        Corrosive to metals    
    Skin Irrit.        Skin irritation    
  Full text of R-phrases referred to under sections 2 and 3
    E        Explosive    
    N        Dangerous for the environment    
    Xn        Harmful    
    R2        Risk of explosion by shock, friction, fire or other sources of ignition.    
    R21/22        Harmful in contact with skin and if swallowed.    
    R36/38        Irritating to eyes and skin.    
    R40        Limited evidence of a carcinogenic effect.    
    R43        May cause sensitisation by skin contact.    
    R48/22        Harmful: danger of serious damage to health by prolonged exposure if swallowed.    
    R50        Very toxic to aquatic organisms.    
  Further information
    Copyright 2013 Co. LLC. License granted to make unlimited paper copies for internal use
    only.
    The above information is believed to be correct but does not purport to be all inclusive and shall be
    used only as a guide. The information in this document is based on the present state of our knowledge
    and is applicable to the product with regard to appropriate safety precautions. It does not represent any
    guarantee of the properties of the product. Corporation and its Affiliates shall not be held
    liable for any damage resulting from handling or from contact with the above product. See
     and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.