(7S)-7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one,(2R,3R)-2,3-dihydroxybutanedioic acid

(7S)-7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one,(2R,3R)-2,3-dihydroxybutanedioic acid 基本信息
CAS号 49720-72-1 分子式 C24H29NO11
分子量 507.48700 精确质量 　507.17400
PSA 　195.07000 LogP 　1.27190
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目录
基本信息 毒性

基本信息 展开↓

CAS号：
49720-72-1
3D弹球模型：
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分子式：
C24H29NO11
分子量：
507.48700
中文名称：
(7S)-7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one,(2R,3R)-2,3-dihydroxybutanedioic acid
英文名称：
(7S)-7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one,(2R,3R)-2,3-dihydroxybutanedioic acid
中文别名：
(7S)-7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one,(2R,3R)-2,3-dihydroxybutanedioic acid
英文别名：
(7S)-7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one,(2R,3R)-2,3-dihydroxybutanedioic acid;
Colchicine,deacetyl-,L-tartrate;
NCI 1136;
TMCA methyl ester d-tartrate,hydrate;
SKF 250;
Trimethylcolchicinic acid,methyl ether,L-tartrate;
Desacetylcolchicine d-tartrate
精确分子量/精确质量：
507.17400
极性分子表面积/PSA：
195.07000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
InChI：
The Key: JLRWNBXMQCGSEJ-APBURCQWSA-N

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GH0980000
CHEMICAL NAME :
Colchicinic acid, trimethyl-methyl ether, d-tartrate, hydrate
CAS REGISTRY NUMBER :
49720-72-1
LAST UPDATED :
199610
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C20-H23-N-O5.C4-H6-O6.H2-O
MOLECULAR WEIGHT :
525.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
200 ug/kg/7D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Blood - leukopenia Blood - thrombocytopenia
REFERENCE :
CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 56,263,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
70520 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
9500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973
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