依降钙素

依降钙素 基本信息
CAS号 60731-46-6 分子式 C148H244N42O47
分子量 3363.77000 精确质量 　3361.80000
PSA 　1435.94000 LogP 　-1.15300
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目录
基本信息 物化性质 安全信息 毒性

基本信息 展开↓

CAS号：
60731-46-6
3D弹球模型：
立即前往扯扯看
分子式：
C148H244N42O47
分子量：
3363.77000
中文名称：
依降钙素
英文名称：
Carbocalcitonin
中文别名：
依降钙素;
3-amino-4-(methoxycarbonyl)benzoic acid;
3-amino-4-(methoxycarbonyl)benzoate;
1-methyl 2-aminoterephthalate;
5-Amino(3,4'-bipyridin)-6(1H)-one;
5-Amino-(3,4'-bipyridin)-6(1H)-one;
AWD 08-250;
Amrinona;
Amrinona [INN-Spanish];
Amrinonum;
Amrinonum [INN-Latin];
BRN 0744819;
CCRIS 3794;
Cordemcura;
Inamrinone;
UNII-JUT23379TN;
WIN 40680;
Wincoram;
5-amino-3,4'-bipyridin-6(1H)-one;
Vesistol;
Inocor;
Wincavam;
Win40680;
amrinone
英文别名：
Carbocalcitonin;
HC-58;
EINECS 262-393-7;
Elcatonin;
1,7-Dicarbacalcitonin (salmon),1-butanoic acid-26-L-aspartic acid-27-L-valine-29-L-alanine;
1,7-Dicarbacalcitonin,1-butanoic acid-26-L-aspartic acid-27-L-valine-29-L-alanine;
Elcatonine [INN-French];
Elcatoninum [INN-Latin];
Elcatonina [INN-Spanish];
Elcatonin Acetate;
(Aminosuberic acid 1,7)-eel calcitonin
精确分子量/精确质量：
3361.80000
极性分子表面积/PSA：
1435.94000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
EINECS：
262-393-7
InChI：
InChI=1/C148H244N42O47/c1-69(2)52-92(178-142(231)115(75(13)14)185-128(217)87-30-21-20-22-36-113(208)237-67-84(151)122(211)172-98(59-107(154)200)136(225)176-96(56-73(9)10)134(223)182-102(66-192)139(228)188-116(77(16)193)143(232)171-87)123(212)161-63-109(20

物化性质展开↓

外观与性状：
白色粉末
折射率：
1.658

安全信息展开↓

海关代码：
2937190090

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HS9270000
CHEMICAL NAME :
1,7-Dicarbacalcitonin (salmon), 1-butanoic acid-26-L-aspartic acid-27-L-valine-29-L-alanine-
CAS REGISTRY NUMBER :
60731-46-6
LAST UPDATED :
199406
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C148-H244-N42-O47
MOLECULAR WEIGHT :
3364.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>185 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,921,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>185 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,921,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>185 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,921,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>185 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,921,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>338 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,921,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>338 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,921,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>338 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,921,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>338 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,921,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
18 ku/kg/26W-C
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,915,1985
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
2240 units/kg/4W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume decreased Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in calcium
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 21,4477,1993
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