奈达铂

奈达铂 基本信息
CAS号 95734-82-0 分子式 C2H8N2O3Pt
分子量 303.17500 精确质量 　303.01800
PSA 　42.01000 LogP 　0.12010
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目录
基本信息 物化性质 合成路线 毒性 上下游

基本信息 展开↓

CAS号：
95734-82-0
分子式：
C2H8N2O3Pt
分子量：
303.17500
中文名称：
奈达铂
英文名称：
nedaplatin
中文别名：
奈达铂;
顺糖氨铂
英文别名：
nedaplatin;
o(sup2))-diammine(hydroxyacetato(2-)-o(sup1(sp-4-3)-platinu;
Nedaplait;
254-s;
Nedaplatin;
cis-diamine-glycolate-O,O'-platinum(II);
PlatinuM,diaMMine[(hydroxy-kO)acetato(2-)-kO]-,(SP-4-3);
(glycolato-O,O')diammine platinum(II);
2,2-diaMino-1,3-dioxa-2-platinacyclopentan-4-one;
cis-diammine(glycolato)platinum(ii)
精确分子量/精确质量：
303.01800
极性分子表面积/PSA：
42.01000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
InChI：
InChI=1/C2H3O3.2H2N.Pt/c3-1-2(4)5;;;/h1H2,(H,4,5);2*1H2;/q3*-1;+4/p-1/rC2H6N2O3Pt/c3-8(4)6-1-2(5)7-8/h1,3-4H2

物化性质展开↓

外观与性状：
稻黄色粉末
沸点：
265.6ºC at 760 mmHg
闪点：
128.7ºC

合成路线查看所有的合成路线

  • 79-14-1

    羟基乙酸

  • +

  • 41575-87-5

    Platinum(2+) nitrate ammoniate (1:2:2)

  • →

    ~43%

  • 95734-82-0

    奈达铂

  • 41575-87-5

    Platinum(2+) nitrate ammoniate (1:2:2)

  • +

  • 25289-18-3

    sodium glycollate

  • →

    ~28%

  • 95734-82-0

    奈达铂

  • 79-14-1

    羟基乙酸

  • +

  • 63700-88-9

    {Pt[a2](OH)2}

  • +

  • 25289-18-3

    sodium glycollate

  • →

  • 95734-82-0

    奈达铂

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TP2482800
CHEMICAL NAME :
Platinum, diammine(hydroxyacetato(2-)-O(sup 1),O(sup 2))-, (SP-4-3)-
CAS REGISTRY NUMBER :
95734-82-0
LAST UPDATED :
199612
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C2-H8-N2-O3-Pt
MOLECULAR WEIGHT :
303.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in sodium
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
44100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
4 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
48600 ug/kg/26W-I
TOXIC EFFECTS :
Cardiac - other changes Kidney, Ureter, Bladder - other changes Endocrine - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
10800 ug/kg/26W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in platelet count Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
45 mg/kg/30D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Ear) - change in acuity Sense Organs and Special Senses (Ear) - changes in cochlear structure or function
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
13 mg/kg
SEX/DURATION :
female 17-21 day(s) after conception lactating female 20 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - physical Related to Chronic Data - changes in ovarian weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
4500 ug/kg
SEX/DURATION :
female 17-21 day(s) after conception lactating female 20 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - physical
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
46 mg/kg
SEX/DURATION :
male 64 day(s) pre-mating female 2 week(s) pre-mating - 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
46 mg/kg
SEX/DURATION :
male 64 day(s) pre-mating female 2 week(s) pre-mating - 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
750 mg/kg
SEX/DURATION :
female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
6300 ug/kg
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 22,821,1991

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  • 41575-87-5

    Platinum(2+) nitrate ammoniate (1:2:2)

  • 25289-18-3

    sodium glycollate

  • 79-14-1

    羟基乙酸

  • 63700-88-9

    {Pt[a2](OH)2}

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