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Section 1. Chemical Product and Company Identification
    Econazole nitrate
    Common Name/
    Trade Name
    Econazole nitrate

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Section 4. First Aid Measures
    Eye Contact        Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for    
    at least 15 minutes. Cold water may be used. WARM water MUST be used. Get medical attention if irritation
    occurs.
    Skin Contact        In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient.    
    Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before
    reuse. Get medical attention.
    Serious Skin Contact
    Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate
    medical attention.
    Inhalation        If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.    
    Get medical attention.
    Serious Inhalation        Not available.    
    Ingestion        Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an    
    unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen
    tight clothing such as a collar, tie, belt or waistband.
    Serious Ingestion        Not available.    

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Section 5. Fire and Explosion Data
    Flammability of the Product May be combustible at high temperature.
    Auto-Ignition Temperature Not available.
    Not available.
    Flash Points
    Flammable Limits        Not available.    
    Products of Combustion        These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds.    
    Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
    Various Substances
    Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
    Risks of explosion of the product in presence of static discharge: Not available.
    of Various Substances
    SMALL FIRE: Use DRY chemical powder.
    Fire Fighting Media
    and Instructions        LARGE FIRE: Use water spray, fog or foam. Do not use water jet.    
    Special Remarks on        Material in powder form, capable of creating a dust explosion.    
    Fire Hazards
    Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential
    dust explosion hazard.
    Hazards

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Section 6. Accidental Release Measures
    Small Spill        Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by    
    spreading water on the contaminated surface and dispose of according to local and regional authority
    requirements.
    Large Spill        Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading    
    water on the contaminated surface and allow to evacuate through the sanitary system.
    Econazole nitrate

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Section 7. Handling and Storage
    Precautions        Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not    
    ingest. Do not breathe dust. Avoid contact with skin. Wear suitable protective clothing. If ingested, seek
    medical advice immediately and show the container or the label.
    Storage        Keep container tightly closed. Keep container in a cool, well-ventilated area. Sensitive to light. Store in    
    light-resistant containers.

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Section 8. Exposure Controls/Personal Protection
    Engineering Controls        Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below    
    recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep
    exposure to airborne contaminants below the exposure limit.
    Personal Protection        Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.    
    Gloves.
    Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be
    a Large Spill        used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a    
    specialist BEFORE handling this product.
    Exposure Limits        Not available.    

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Section 9. Physical and Chemical Properties
    Physical state and appearance Solid. (crystalline powder.)        Not available.    
    Odor
    Taste        Not available.    
    Molecular Weight        440.7 g/mole    
    Color        White. Off-white.    
    pH (1% soln/water)        Not available.    
    Boiling Point        Not available.    
    Melting Point        162°C (323.6°F)    
    Critical Temperature        Not available.    
    Not available.
    Specific Gravity
    Vapor Pressure        Not applicable.    
    Not available.
    Vapor Density
    Volatility        Not available.    
    Odor Threshold        Not available.    
    Water/Oil Dist. Coeff.        Not available.    
    Ionicity (in Water)        Not available.    
    See solubility in water, methanol.
    Dispersion Properties
    Solubility        Soluble in methanol.    
    Very slightly soluble in cold water.

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Section 10. Stability and Reactivity Data
    The product is stable.
    Stability
    Instability Temperature        Not available.    
    Excess heat, dust generation
    Conditions of Instability
    Incompatibility with various        Not available.    
    substances
    Corrosivity        Non-corrosive in presence of glass.    
    Special Remarks on        Sensitive to light.    
    Reactivity
    Econazole nitrate
    Not available.
    Special Remarks on
    Corrosivity
    Polymerization        Will not occur.    

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Section 11. Toxicological Information
    Routes of Entry        Inhalation. Ingestion.    
    Toxicity to Animals        Acute oral toxicity (LD50): 431 mg/kg [Rabbit].    
    Chronic Effects on Humans Not available.
    Other Toxic Effects on        Hazardous in case of skin contact (irritant).    
    Humans        Slightly hazardous in case of ingestion, of inhalation.    
    Special Remarks on        Not available.    
    Toxicity to Animals
    Special Remarks on        May affect genetic material (mutagenic).    
    Chronic Effects on Humans        May cause adverse reproductive effects and birth defects (teratogenic) based on animal test data    
    Special Remarks on other        Acute Potential Health Effects:    
    Toxic Effects on Humans        Skin: Can cause skin irritation.    
    Eyes: Can cause eye irritation.
    Inhalation: May cause respiratory tract irritation.
    Ingestion: May be harmful if swallowed. May affect behavior/central nervous system (tremor, convulsions),
    respiration (dyspnea), liver, blood (changes in serum composition)

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Section 12. Ecological Information
    Ecotoxicity        Not available.    
    BOD5 and COD        Not available.    
    Products of Biodegradation        Possibly hazardous short term degradation products are not likely. However, long term degradation products    
    may arise.
    Toxicity of the Products        The products of degradation are as toxic as the product itself.    
    of Biodegradation
    Special Remarks on the        Not available.    
    Products of Biodegradation

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Section 13. Disposal Considerations
    Waste Disposal        Waste must be disposed of in accordance with federal, state and local environmental    
    control regulations.

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Section 14. Transport Information
    DOT Classification        Not a DOT controlled material (United States).    
    Not applicable.
    Identification
    Special Provisions for        Not applicable.    
    Transport
    DOT (Pictograms)
    Econazole nitrate

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Section 15. Other Regulatory Information and Pictograms
    New Jersey: Econazole nitrate
    Federal and State
    Regulations
    California        California prop. 65: This product contains the following ingredients for which the State of California has    
    Proposition 65        found to cause cancer which would require a warning under the statute: No products were found.    
    Warnings
    California prop. 65: This product contains the following ingredients for which the State of California has
    found to cause birth defects which would require a warning under the statute: No products were found.
    Other Regulations        OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).    
    EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS
    No. 272-295-6).
    Canada: Not listed on Canadian Domestic Substance List (DSL) or Canadian Non-Domestic Substances List
    (NDSL)
    China: Not listed on National Inventory.
    Japan: Not listed on National Inventory (ENCS).
    Korea: Listed on National Inventory (KECI).
    Philippines: Not listed on National Inventory (PICCS).
    Australia: Listed on AICS.
    WHMIS (Canada) CLASS D-2B: Material causing other toxic effects (TOXIC).
    Other Classifications
    DSCL (EEC)        R22- Harmful if swallowed.        S26- In case of contact with eyes, rinse    
    R36/38- Irritating to eyes and skin.        immediately with plenty of water and seek    
    medical advice.
    S37- Wear suitable gloves.
    S46- If swallowed, seek medical advice
    immediately and show this container or label.
    Health Hazard
    HMIS (U.S.A.)        1 National Fire Protection    
    1 Flammability
    1 Association (U.S.A.)
    Fire Hazard
    1 0 Reactivity
    Health
    Reactivity
    0
    Specific hazard
    Personal Protection
    E
    WHMIS (Canada)
    (Pictograms)
    DSCL (Europe)
    (Pictograms)
    TDG (Canada)
    (Pictograms)
    ADR (Europe)
    (Pictograms)
    Protective Equipment
    Gloves.
    Lab coat.
    Econazole nitrate
    Dust respirator. Be sure to use an
    approved/certified respirator or
    equivalent. Wear appropriate
    respirator when ventilation is
    inadequate.

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SECTION 16 - ADDITIONAL INFORMATION
N/A