戈舍瑞林

戈舍瑞林 基本信息
CAS号 65807-02-5 分子式 C59H79D5N18O14
分子量 1274.44000 精确质量 　1273.67000
PSA 　493.39000 LogP 　2.78000
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目录
基本信息 制备方法与用途 物化性质 安全信息 毒性

基本信息 展开↓

CAS号：
65807-02-5
3D弹球模型：
立即前往扯扯看
分子式：
C59H79D5N18O14
分子量：
1274.44000
中文名称：
戈舍瑞林
英文名称：
Goserelin
中文别名：
戈舍瑞林;
高舍瑞林
英文别名：
Goserelin;
5-oxoprolylhistidyl-N-[18,18-diamino-7-(tert-butoxymethyl)-13-({2-[(2-carbamoylhydrazinyl)carbonyl]pyrrolidin-1-yl}carbonyl)-4-(4-hydroxybenzyl)-1-(hydroxymethyl)-10-(2-methylpropyl)-2,5,8,11-tetraoxo-3,6,9,12,17-pentaazaoctadec-17-en-1-yl]tryptophanamide;
5-oxo-L-prolyl-L-histidyl-N-[(1S,4S,7R,10S,13S)-18,18-diamino-7-(tert-butoxymethyl)-13-({(2S)-2-[(2-carbamoylhydrazino)carbonyl]pyrrolidin-1-yl}carbonyl)-4-(4-hydroxybenzyl)-1-(hydroxymethyl)-10-(2-methylpropyl)-2,5,8,11-tetraoxo-3,6,9,12,17-pentaazaoctad;
戈舍瑞林;
4-amino-6-hydroxy-2-mercaptopyrimidine;
4-Amino-6-hydroxy-2-mercaptopyrimidine monohydrate;
Z-D-glutamic acid 1-benzyl ester;
N-Methyl-D-alanine hydrochloride;
UNII-65NK71K78P;
L-lysyl-N-(2-benzoyl-4-chlorophenyl)-N-methylglycinamide;
Avizafone;
piperidyl-succinat);
dimethyl succinate polymer w/4-hydroxy-2,2,6,6-;
tetramethyl-1-piperidine ethanol;
Primesorb622;
Poly-(N-β-hydroxyethyl-2,2,6,6-tetramethyl-4-hydroxy-piperidyl)succinate;
TINUVIN 622;
Poly-(N--hydroxyethyl-2,2,6,6-tetramethyl-4-hydroxy-piperid
精确分子量/精确质量：
1273.67000
极性分子表面积/PSA：
493.39000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
InChI：
InChI=1/C59H84N18O14/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25

生产制备方法及用途展开↓

制备方法

治疗前列腺癌及绝经期乳腺癌,子宫内膜异位症

用途简介

物化性质展开↓

外观与性状：
白色固体
密度：
1.5 g/cm3
折射率：
1.692

安全信息展开↓

安全说明：
S22-S24/25

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OK6369800
CHEMICAL NAME :
Luteinizing hormone-releasing factor (pig), 6-(O-1,1-dimethylethyl)-D-serene)-10- deglycinamide-, 2-(aminocarbonyl)hydrazide
CAS REGISTRY NUMBER :
65807-02-5
LAST UPDATED :
199510
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C59-H84-N18-O14
MOLECULAR WEIGHT :
1269.61

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
51 ug/kg
TOXIC EFFECTS :
Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Sense Organs and Special Senses (Eye) - diplopia Nutritional and Gross Metabolic - other changes
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 345,458,1995 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
12 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
JOAND3 Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980- Volume(issue)/page/year: 10,478,1989
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
12 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male Endocrine - androgenic
REFERENCE :
JOAND3 Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980- Volume(issue)/page/year: 10,478,1989
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