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Section 1. Chemical Product and Company Identification
    Norepinerphrine Bitartrate, Monohydrate Catalog
    N3233, N3550
    Common Name/
    Number(s).
    Trade Name
    CAS#        69815-49-2 or 108341-18-0;    
    51-40-1[anhydrous]
    Manufacturer
    Commercial Name(s)
    Norepinerphrine Bitartrate, Monohydrate

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Section 3. Hazards Identification
    Potential Acute Health Effects Very hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant),
    of inhalation. Severe over-exposure can result in death.
    Potential Chronic Health        CARCINOGENIC EFFECTS: Not available.    
    Effects        MUTAGENIC EFFECTS: Not available.    
    TERATOGENIC EFFECTS: Not available.
    DEVELOPMENTAL TOXICITY: Not available.
    The substance may be toxic to the nervous system, heart, cardiovascular system, Smooth muscle.
    Repeated or prolonged exposure to the substance can produce target organs damage.

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Section 4. First Aid Measures
    Eye Contact        Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at    
    least 15 minutes. Get medical attention if irritation occurs.
    Skin Contact        Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.    
    Serious Skin Contact        Not available.    
    Inhalation        If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get    
    medical attention.
    Serious Inhalation        Not available.    
    Ingestion        Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an    
    unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
    clothing such as a collar, tie, belt or waistband.
    Serious Ingestion        Not available.    

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Section 5. Fire and Explosion Data
    Flammability of the Product May be combustible at high temperature.
    Auto-Ignition Temperature Not available.
    Flash Points        Not available.    
    Flammable Limits        Not available.    
    These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
    Products of Combustion
    Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
    Various Substances
    Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
    of Various Substances        Risks of explosion of the product in presence of static discharge: Not available.    
    Fire Fighting Media        SMALL FIRE: Use DRY chemical powder.    
    and Instructions        LARGE FIRE: Use water spray, fog or foam. Do not use water jet.    
    Special Remarks on        Not available.    
    Fire Hazards
    Special Remarks on Explosion Not available.
    Hazards
    Norepinerphrine Bitartrate, Monohydrate

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Section 6. Accidental Release Measures
    Small Spill        Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by    
    spreading water on the contaminated surface and dispose of according to local and regional authority
    requirements.
    Large Spill        Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water    
    on the contaminated surface and allow to evacuate through the sanitary system.

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Section 7. Handling and Storage
    Precautions        Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not    
    breathe dust. Keep away from incompatibles such as oxidizing agents, acids, alkalis.
    Storage        Keep container tightly closed. Keep container in a cool, well-ventilated area. Air Sensitive Sensitive to light.    
    Store in light-resistant containers.

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Section 8. Exposure Controls/Personal Protection
    Engineering Controls        Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below    
    recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
    airborne contaminants below the exposure limit.
    Personal Protection        Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.    
    Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
    a Large Spill        to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist    
    BEFORE handling this product.
    Exposure Limits        Not available.    

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Section 9. Physical and Chemical Properties
    Physical state and appearance Solid.        Odor        Not available.    
    Taste        Not available.    
    Molecular Weight        337.3 g/mole    
    Not available.
    Color
    Not available.
    pH (1% soln/water)
    Boiling Point        Not available.    
    100°C (212°F)
    Melting Point
    Critical Temperature        Not available.    
    Specific Gravity        Not available.    
    Vapor Pressure        Not applicable.    
    Vapor Density        Not available.    
    Volatility        Not available.    
    Odor Threshold        Not available.    
    Water/Oil Dist. Coeff.        Not available.    
    Ionicity (in Water)        Not available.    
    Dispersion Properties        Not available.    
    Solubility        Not available.    
    Norepinerphrine Bitartrate, Monohydrate

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Section 10. Stability and Reactivity Data
    The product is stable.
    Stability
    Instability Temperature        Not available.    
    Excess heat, incompatible materials, light, air.
    Conditions of Instability
    Reactive with oxidizing agents, acids, alkalis.
    Incompatibility with various
    substances
    Corrosivity        Not available.    
    Special Remarks on        Air and light sensitive.    
    Reactivity
    Special Remarks on        Not available.    
    Corrosivity
    Polymerization        Will not occur.    

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Section 11. Toxicological Information
    Routes of Entry        Inhalation. Ingestion.    
    Toxicity to Animals        LD50: Not available.    
    LC50: Not available.
    Chronic Effects on Humans May cause damage to the following organs: the nervous system, heart, cardiovascular system, Smooth muscle.
    Other Toxic Effects on        Very hazardous in case of ingestion.    
    Humans        Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation.    
    Special Remarks on        Not available.    
    Toxicity to Animals
    Special Remarks on        Not available.    
    Chronic Effects on Humans
    Special Remarks on other        Acute Potential Health Effects:    
    Toxic Effects on Humans        Skin: May cause skin irritation.    
    Eyes: May cause eye irritation.
    Inhalation: Dust may cause respiratory tract irritation with coughing, wheezing, shortness of breath
    Ingestion: May be fatal if swallowed. May cause nausea, vomiting, sweating, photophobia. May affect
    behavior/central nervous system (headache, anxiety, dizziness, weakness, mental/mood changes, convulsions,
    excitement), respiration (respiratory difficulty, respiratory stimulation), cardiovascular system/heart (palpitations,
    hypertension, cardiac arrhythmias, fast or slow heartbeat).
    Medical Conditions Aggravated by Exposure: Mesenteric or peripheral thrombosis (blood clots); hypertension;
    dehydration; thyroid problems (especially hyperthyroidism); (taking monoamine oxidase inhibitors (MAO) or
    antidepressants of the triptyline or imipramine types; during Cyclopropane or halthane anesthesia.

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Section 12. Ecological Information
    Ecotoxicity        Not available.    
    BOD5 and COD        Not available.    
    Products of Biodegradation        Possibly hazardous short term degradation products are not likely. However, long term degradation products may    
    arise.
    Toxicity of the Products        The product itself and its products of degradation are not toxic.    
    of Biodegradation
    Special Remarks on the        Not available.    
    Products of Biodegradation
    Norepinerphrine Bitartrate, Monohydrate

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Section 13. Disposal Considerations
    Waste Disposal        Waste must be disposed of in accordance with federal, state and local environmental    
    control regulations.

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Section 14. Transport Information
    DOT Classification        CLASS 6.1: Poisonous material.    
    : Toxic solid, organic (norepinephrine bitartrate monohydrate) UNNA: 2811 PG: II
    Identification
    Not available.
    Special Provisions for
    Transport
    DOT (Pictograms)

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Section 15. Other Regulatory Information and Pictograms
    No products were found.
    Federal and State
    Regulations
    California        California prop. 65: This product contains the following ingredients for which the State of California has found    
    to cause cancer which would require a warning under the statute: No products were found.
    Proposition 65
    Warnings
    California prop. 65: This product contains the following ingredients for which the State of California has found
    to cause birth defects which would require a warning under the statute: No products were found.
    Other Regulations        EINECS: This product is not on the European Inventory of Existing Commercial Chemical Substances.    
    Canada: Not listed on Canadian Domestic Substance List (DSL) or Canadian Non-Domestic Substances List
    (NDSL)
    China: Not isted on National Inventory.
    Japan: Not isted on National Inventory (ENCS).
    Korea: Not listed on National Inventory (KECI).
    Philippines: Not listed on National Inventory (PICCS).
    Australia: Not isted on AICS.
    WHMIS (Canada) CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC).
    Other Classifications
    DSCL (EEC)        R28- Very toxic if swallowed.        S28- After contact with skin, wash immediately    
    with plenty of [***]
    S36/37- Wear suitable protective clothing and
    gloves.
    S45- In case of accident or if you feel unwell,
    seek medical advice immediately (show the
    label where possible).
    Health Hazard
    HMIS (U.S.A.)        3 National Fire Protection    
    1 Flammability
    1 Association (U.S.A.)
    Fire Hazard
    3 0 Reactivity
    Health
    Reactivity
    0
    Specific hazard
    Personal Protection
    E
    WHMIS (Canada)
    (Pictograms)
    Norepinerphrine Bitartrate, Monohydrate
    DSCL (Europe)
    (Pictograms)
    TDG (Canada)
    (Pictograms)
    ADR (Europe)
    (Pictograms)
    Protective Equipment
    Gloves.
    Lab coat.
    Dust respirator. Be sure to use an
    approved/certified respirator or
    equivalent.

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SECTION 16 - ADDITIONAL INFORMATION
N/A