6α-甲基泼尼松龙

6α-甲基泼尼松龙 基本信息
CAS号 83-43-2 分子式 C22H30O5
分子量 374.47100 精确质量 　374.20900
PSA 　94.83000 LogP 　1.80360
我要卖该产品 我要采购该产品

等价的CAS号：

83-43-2,6923-42-8,18462-27-6,105500-05-8
充值推广 查看更多供应商
目录
基本信息 制备方法与用途 物化性质 安全信息 合成路线 化学图谱 毒性 MSDS 结构与计算数据 上下游

基本信息 展开↓

CAS号：
83-43-2
3D弹球模型：
立即前往扯扯看
分子式：
C22H30O5
分子量：
374.47100
中文名称：
6α-甲基泼尼松龙
英文名称：
6α-methylprednisolone
中文别名：
6α-甲基泼尼松龙;
11β,17α,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione;
甲基泼尼松龙;
11β,17α,21-三羟基-6α-甲基-1,4-孕甾二烯-3,20-二酮;
甲基强的松龙;
甲基氢化泼尼松;
6α-甲基-11β,17α,21-三羟基-1,4-孕甾二烯-3,20-二酮
英文别名：
6α-methylprednisolone;
6alpha-methylprednisolone;
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one;
Methylprednisolone
精确分子量/精确质量：
374.20900
极性分子表面积/PSA：
94.83000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
贝尔斯坦号/MDL：
MFCD00010591
EINECS：
201-476-4
PubChem：
24896564
BRN：
2340300
InChI：
InChI=1/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14?,15?,17-,19?,20-,21-,22-/m0/s1

生产制备方法及用途展开↓

制备方法

用于生化研究。适用于风湿性关节炎、胶原病、过敏性疾病、眼科疾患、淋巴白血病、软组织炎症及溶血性贫血等。

用途简介

用途

用于生化研究。适用于风湿性关节炎、胶原病、过敏性疾病、眼科疾患、淋巴白血病、软组织炎症及溶血性贫血等。

物化性质展开↓

外观与性状：
白色至灰白色结晶粉末
密度：
1.28
熔点：
228-237°C (dec.)
沸点：
571.8ºC at 760 mmHg
闪点：
313.7°C
折射率：
82 ° (C=1, Dioxane)
存储条件/存储方法：

本品应密封干燥保存。

其它信息：

1.      性状：无色结晶。

2.      密度（g/mL,25/4℃）：不确定

3.      相对蒸汽密度（g/mL,空气=1）：不确定

4.      熔点（ºC）：228～237℃

5.      沸点（ºC,常压）：不确定

6.      沸点（ºC,5.2kPa）：不确定

7.      折射率：不确定

8.      闪点（ºC）：不确定

9.      比旋光度（º）：[α]D20+83°（二氧六环中）。

10.   自燃点或引燃温度（ºC）：不确定

11.   蒸气压（kPa,25ºC）：不确定

12.   饱和蒸气压（kPa,60ºC）：不确定

13.   燃烧热（KJ/mol）：不确定

14.   临界温度（ºC）：不确定

15.   临界压力（KPa）：不确定

16.   油水（辛醇/水）分配系数的对数值：不确定

17.   爆炸上限（%,V/V）：不确定

18.   爆炸下限（%,V/V）：不确定

19.   溶解性：略微溶于乙醇、二氧六环、甲醇，微溶于丙酮、氯仿，极微溶于乙醚，不溶于水

安全信息展开↓

WGK_Germany：
2
德国有关水污染物质的分类清单
危险类别码：
R36/37/38
安全说明：
S22-S36
RTECS号：
TU4146000
安全标志：
S22:不要吸入粉尘。
S36:穿戴合适的防护服装。
危险标志：
Xi

合成路线查看所有的合成路线

  • 77074-42-1

    6α-甲基泼尼松龙17 - 半琥珀酸酯

  • →

  • 83-43-2

    6α-甲基泼尼松龙

  • +

  • 2921-57-5

    甲基泼尼松龙琥珀酸酯

  • 2921-57-5

    甲基泼尼松龙琥珀酸酯

  • →

  • 83-43-2

    6α-甲基泼尼松龙

  • +

  • 77074-42-1

    6α-甲基泼尼松龙17 - 半琥珀酸酯

  • 86401-94-7

    86401-94-7

  • →

  • 83-43-2

    6α-甲基泼尼松龙

  • +

  • 53-36-1

    醋酸甲泼尼龙

化学图谱

  1. 甲基泼尼松龙质谱(MS)

  2. 甲基泼尼松龙红外图谱(IR1)

  3. 甲基泼尼松龙红外图谱(IR2)

上一页 1/4 下一页

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU4146000
CHEMICAL NAME :
Pregna-1,4-diene-3,20-dione, 6-alpha-methyl-11-beta-17,21-trihydroxy-
CAS REGISTRY NUMBER :
83-43-2
BEILSTEIN REFERENCE NO. :
2340300
LAST UPDATED :
199701
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C22-H30-O5
MOLECULAR WEIGHT :
374.52
WISWESSER LINE NOTATION :
L E5 B666 OV AHTTT&J A1 CQ E1 FV1Q FQ L1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
2400 ug/kg
TOXIC EFFECTS :
Cardiac - change in rate Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
BJANAD British Journal of Anesthesia. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1923- Volume(issue)/page/year: 69,422,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
60 mg/kg/3D-I
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP Vascular - BP lowering not characterized in autonomic section Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 99,282,1983
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
20 mg/kg/45M-C
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont., Canada) V.1- 1974- Volume(issue)/page/year: 13,477,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,832,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2292 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,832,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
210 mg/kg/6W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - changes in sodium
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,305,1959 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84067 No. of Facilities: 33 (estimated) No. of Industries: 2 No. of Occupations: 1 No. of Employees: 272 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84067 No. of Facilities: 42 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2047 (estimated) No. of Female Employees: 983 (estimated)
毒理学数据：

1、急性毒性：

人肠道TDLO：2400ug/kg；人静脉TDLO：60mg/kg/3D-I

人静脉TDLO：20mg/kg/45W-C

大鼠口径LD50：>4mg/kg；

小鼠腹腔LD50：2292mg/kg；

2、其他多剂量毒性：

狗口径TDL0：210mg/kg/6W-I

MSDS 展开↓

Name: 6-alpha-Methylprednisolone 99% Material Safety Data Sheet
Synonym: Medro
CAS: 83-43-2
Section 1 - Chemical Product   MSDS Name:6-alpha-Methylprednisolone 99% Material Safety Data Sheet
Synonym:Medro
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
83-43-2 6-alpha-Methylprednisolone 99% 201-476-4
Hazard Symbols: XN
Risk Phrases: 40
Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Limited evidence of a carcinogenic effect.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
Harmful if absorbed through the skin.
Ingestion:
Harmful if swallowed.
Inhalation:
Harmful if inhaled. May cause irritation of the respiratory tract with burning pain in the nose and throat, coughing, wheezing, shortness of breath and pulmonary edema.
Chronic:
Not available.
Section 4 - FIRST AID MEASURES
  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide.
Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.
Section 7 - HANDLING and STORAGE
  Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 83-43-2: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Powder
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 227-231 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Insoluble.
Specific Gravity/Density:
Molecular Formula: C22H30O5
Molecular Weight: 374.207
Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents, acids, acid chlorides, carbon dioxide, acid anhydrides.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 83-43-2: TU4146000 LD50/LC50:
CAS# 83-43-2: Oral, rat: LD50 = >4 gm/kg.
Carcinogenicity:
6-alpha-Methylprednisolone - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
 
Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
 
IATA
No information available.
IMO
No information available.
RID/ADR
No information available.
Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 40 Limited evidence of a carcinogenic effect.
Safety Phrases:
S 36/37 Wear suitable protective clothing and
gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 83-43-2: No information available.
Canada
CAS# 83-43-2 is listed on Canada's NDSL List.
CAS# 83-43-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 83-43-2 is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION
N/A

分子结构与计算化学数据展开↓

分子结构数据

1、  摩尔折射率：100.08

2、  摩尔体积（m3/mol）：291.4

3、  等张比容（90.2K）：804.8

4、  表面张力（dyne/cm）：58.1

5、  极化率（10-24cm3）：39.67

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:3

3.氢键受体数量:5

4.可旋转化学键数量:2

5.互变异构体数量:9

6.拓扑分子极性表面积94.8

7.重原子数量:27

8.表面电荷:0

9.复杂度:754

10.同位素原子数量:0

11.确定原子立构中心数量:8

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

上下游相关产品

上游产品

更多

  • 117888-35-4

    (20Ξ)-11β-hydroxy-6α-methyl-17,20,20,21-bis-methylenedioxy-pregna-1,4-dien-3-one

  • 53-06-5

    可的松

  • 3386-04-7

    11β,21-dihydroxy-6α-methyl-pregna-4,17(20)c-dien-3-one

  • 1968-76-9

    N/A

  • 3607-68-9

    17α,20,20,21-bismethylenedioxypregn-4-ene-3,11-dione

下游产品

更多

  • 53-36-1

    醋酸甲泼尼龙

  • 359-80-8

    1-[4-(2-methylbutan-2-yl)phenoxy]butan-2-yl prop-2-ynyl sulfite

  • 1625-39-4

    2a-methylcortisol

  • 437-99-0

    Pregna-1,4-diene-3,20-dione, 21-fluoro-11.β.,17-dihydroxy-6.α.-methyl-

立即下载安装“化学加”APP
专业、功能强大，随时调用更加方便
下载APP