CHEMICAL IDENTIFICATION

RTECS NUMBER :

CU3350000

CHEMICAL NAME :

Benz(c)acridine-7-carboxylic acid, 5,6-dihydro-

CAS REGISTRY NUMBER :

83-93-2

BEILSTEIN REFERENCE NO. :

0256492

LAST UPDATED :

199709

DATA ITEMS CITED :

3

MOLECULAR FORMULA :

C18-H13-N-O2

MOLECULAR WEIGHT :

275.32

WISWESSER LINE NOTATION :

T D6 C666 BN&T&&J MVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

760 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,27,1955

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Mammal - cat

DOSE/DURATION :

40 mg/kg

TOXIC EFFECTS :

Vascular - BP lowering not characterized in autonomic section

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,27,1955

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

40 mg/kg

TOXIC EFFECTS :

Behavioral - tetany Cardiac - other changes Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,371,1955