乳酸依沙吖啶

乳酸依沙吖啶 基本信息
CAS号 1837-57-6 分子式 C18H21N3O4
分子量 343.37700 精确质量 　343.15300
PSA 　131.69000 LogP 　3.56530
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目录
基本信息 制备方法与用途 物化性质 安全信息 化学图谱 毒性 MSDS 海关数据 结构与计算数据

基本信息 展开↓

CAS号：
1837-57-6
分子式：
C18H21N3O4
分子量：
343.37700
中文名称：
乳酸依沙吖啶
英文名称：
6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE
中文别名：
乳酸依沙吖啶;
2-乙氧基-6,9-二氨基吖啶乳酸盐;
雷佛奴尔;
乳酸依沙吖啶(一水物);
6,9-二胺-2-乙氧吖啶;
雷凡醇
英文别名：
6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE;
Vucine;
rimaon;
Ethacridine Lactate;
ACRYNOL;
ETHODIN;
flavitrol;
metifex;
RIVANOL;
Ethacridine lactate;
ACRINOL;
2-ethoxy-6,9-diaminoacridine lactate;
rivinol;
7-ethoxy-acridine-3,9-diyldiamine,DL lactate
精确分子量/精确质量：
343.15300
极性分子表面积/PSA：
131.69000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
EINECS：
217-408-1
InChI：
InChI=1/C15H15N3O.C3H6O3/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13;1-2(4)3(5)6/h3-8H,2,16H2,1H3,(H2,17,18);2,4H,1H3,(H,5,6)

生产制备方法及用途展开↓

制备方法

抗生素类抗感染原料药，用于消毒防腐，用于创面及粘膜的消毒，血浆蛋白制备过程中的沉淀分离剂，针剂用于中期引产。

用途简介

用途

为外用杀菌防腐剂，对革兰阳性细菌及少数革兰阴性细菌有较强的杀灭作用，对球菌尤其是链球菌的抗菌作用较强。用于各种创伤，渗出、糜烂的感染性皮肤病及伤口冲洗。

物化性质展开↓

熔点：
62-67 °C(lit.)
沸点：
270 °C(lit.)
闪点：
143 °C
水溶解性：
soluble
蒸汽压：
4.72E-11mmHg at 25°C
存储条件/存储方法：

保持贮藏器密封、储存在阴凉、干燥的地方，确保工作间有良好的通风或排气装置

稳定性相关：

如果遵照规格使用和储存则不会分解，未有已知危险反应，避免氧化物

        

其它信息：

1.       性状：粉末

2.       密度（g/mL,25ºC）：未确定

3.       相对蒸汽密度（g/mL,空气=1）： 未确定

4.       熔点（ºC）：245

5.       沸点（ºC）：未确定

6.       沸点（ºC，0.4mmHg）：未确定

7.       折射率：未确定

8.       闪点（°C）：未确定

9.       比旋光度（ºC）：未确定

10.    自燃点或引燃温度（ºC）：未确定

11.    蒸气压（kPa,109ºC）：未确定

12.    饱和蒸气压（kPa,60ºC）：未确定

13.    燃烧热（KJ/mol）：未确定

14.    临界温度（ºC）：未确定

15.    临界压力（KPa）：未确定

16.    油水（辛醇/水）分配系数的对数值：未确定

17.    爆炸上限（%,V/V）：未确定

18.    爆炸下限（%,V/V）：未确定

19.    溶解性：能溶解于水的

安全信息展开↓

海关代码：
2933990090
WGK_Germany：
3
德国有关水污染物质的分类清单
危险类别码：
R36/37/38:Irritating to eyes, respiratory system and skin . R22:Harmful if swallowed. R40:Limited evidence of a carcinogenic effect. R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
安全说明：
S26-S24/25-S37/39
RTECS号：
UT6410000
危险标志：
Xi,Xn

化学图谱

  1. 乳酸2-乙氧基-6,9-二氨基吖啶一水合物核磁图(13CNMR)

  2. 乳酸2-乙氧基-6,9-二氨基吖啶一水合物核磁图(1HNMR)

  3. 乳酸2-乙氧基-6,9-二氨基吖啶一水合物质谱(MS)

  4. 乳酸2-乙氧基-6,9-二氨基吖啶一水合物红外图谱(IR1)

  5. 乳酸2-乙氧基-6,9-二氨基吖啶一水合物红外图谱(IR2)

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毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OD4725000
CAS REGISTRY NUMBER :
1837-57-6
LAST UPDATED :
199806
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C15-H15-N3-O.C3-H6-O3
MOLECULAR WEIGHT :
343.42
WISWESSER LINE NOTATION :
T C666 BNJ EZ IZ LO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Vascular - shock
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
48 gm/kg/30D-C
TOXIC EFFECTS :
Endocrine - other changes Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
420 mg/kg/21D-I
TOXIC EFFECTS :
Liver - changes in liver weight Endocrine - changes in spleen weight

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Microorganism - not otherwise specified
DOSE/DURATION :
250 mg/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 56,500,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5763 No. of Facilities: 23 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 23 (estimated)
毒理学数据：

1、急性毒性：小鼠经皮下LD50：120mg/kg；兔子经皮下LD50：100mg/kg；兔子经静脉LDLo：20mg/kg；

2、其他多剂量毒性：大鼠经口TDLo：48mg/kg/30D-C；小鼠经腹腔TDLo：420mg/kg/21D-I；

3、   致突变性

微生物鼠伤寒沙门氏菌突变测试系统：16μg/plate；

大肠埃希氏菌DNA加和测试系统：5μmol/L；

枯草芽孢杆菌DNA修复测试系统：1mg/L；

微生物突变测试系统：250mg/L。

生态数据：

对水是稍微有危害的不要让未稀释或大量的产品接触地下水、水道或者污水系统，若无政府许可，勿将材料排入周围环境

MSDS 展开↓

Name: 6 9-Diamino-2-Ethoxyacridine Lactate 95% (Titr.) Material Safety Data Sheet
Synonym: 6,9-Acridinediamine, 2-Ethoxy-, 2-Hydroxypropanote; Acrinol; Ethodin
CAS: 1837-57-6
Section 1 - Chemical Product   MSDS Name:6 9-Diamino-2-Ethoxyacridine Lactate 95% (Titr.) Material Safety Data Sheet
Synonym:6,9-Acridinediamine, 2-Ethoxy-, 2-Hydroxypropanote; Acrinol; Ethodin
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
1837-57-6 Propanoic acid, 2-hydroxy-, compd. wit 95 217-408-1
Hazard Symbols: None Listed.
Risk Phrases: None Listed.
Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation. The toxicological properties of this material have not been fully investigated.
Skin:
May cause skin irritation. The toxicological properties of this material have not been fully investigated.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.
Section 4 - FIRST AID MEASURES
  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.
Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 1837-57-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Powder
Color: yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: N/A
Explosion Limits, upper: N/A
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C18H21N3O4.H2O
Molecular Weight: 361.39
Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported
Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 1837-57-6: OD4725000 LD50/LC50:
Not available.
Carcinogenicity:
Propanoic acid, 2-hydroxy-, compd. with7-ethoxy-3,9-acridine - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
 
Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
 
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.
Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 1837-57-6: No information available.
Canada
CAS# 1837-57-6 is listed on Canada's NDSL List.
CAS# 1837-57-6 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1837-57-6 is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION
N/A

海关数据查看详细

中国海关编码：2933990090

概述：
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素：
品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
摘要/Summary：
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

分子结构与计算化学数据展开↓

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:4

3.氢键受体数量:7

4.可旋转化学键数量:3

5.互变异构体数量:22

6.拓扑分子极性表面积132

7.重原子数量:25

8.表面电荷:0

9.复杂度:371

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:1

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:2

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