曲莫前列素

曲莫前列素 基本信息
CAS号 69900-72-7 分子式 C23H38O4
分子量 378.54500 精确质量 　378.27700
PSA 　74.60000 LogP 　5.16240
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目录
基本信息 物化性质 毒性

基本信息 展开↓

CAS号：
69900-72-7
分子式：
C23H38O4
分子量：
378.54500
中文名称：
曲莫前列素
英文名称：
TRIMOPROSTIL
中文别名：
曲莫前列素
英文别名：
TRIMOPROSTIL
精确分子量/精确质量：
378.27700
极性分子表面积/PSA：
74.60000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。

物化性质展开↓

密度：
1.043g/cm3
沸点：
528.2ºC at 760 mmHg
闪点：
287.3ºC
折射率：
1.527

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UK8010000
CHEMICAL NAME :
Prosta-5,13-dien-1-oic acid, 15-hydroxy-9-oxo-11,16,16-trimethyl-, (5Z,11-alpha,13E,15R)-
CAS REGISTRY NUMBER :
69900-72-7
LAST UPDATED :
199009
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C23-H38-O4
MOLECULAR WEIGHT :
378.61

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
22 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952- Volume(issue)/page/year: 35,2199,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
17 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952- Volume(issue)/page/year: 35,2199,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
28 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952- Volume(issue)/page/year: 35,2199,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
39 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea
REFERENCE :
SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952- Volume(issue)/page/year: 35,2199,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
62 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea
REFERENCE :
SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952- Volume(issue)/page/year: 35,2199,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
65 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea
REFERENCE :
SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952- Volume(issue)/page/year: 35,2199,1986
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