甲烯土霉素

甲烯土霉素 基本信息
CAS号 914-00-1 分子式 C22H22N2O8
分子量 442.41900 精确质量  442.13800
PSA  181.62000 LogP  0.26240

基本信息 展开↓

CAS号:
914-00-1
3D弹球模型:
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分子式:
C22H22N2O8
分子量:
442.41900
中文名称:
甲烯土霉素
英文名称:
methacycline
中文别名:
甲烯土霉素;
美他环素
英文别名:
methacycline;
Germicilclin;
Adriamicina;
gs-2876;
6-methylene-oxytetracyclin;
METHACYCLINE;
Globociclina;
6-methyleneoxytetracycline;
rondomycin;
metacycline;
bialatan;
methacyclineamphoteric;
Cyclobiotic;
12aalpha))-ph
精确分子量/精确质量:
442.13800
极性分子表面积/PSA:
181.62000
油水分配系数/LogP:

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值,反映了物质在油水两相中的分配情况。其中、LogP值越大,说明该物质越亲油;反之,LogP值越小,则说明该物质越亲水。
EINECS:
213-017-5
InChI:
InChI=1/C22H22N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-6,10,14-15,17,25-27,31-32H,1,23H2,2-3H3/b21-13+/t10-,14-,15+,17+,22+/m1/s1

生产制备方法及用途展开↓

制备方法


用作抗生素类药

用途简介


物化性质展开↓

密度:
1.66g/cm3
沸点:
695.1ºC at 760mmHg
闪点:
374.2ºC
折射率:
1.753

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QI9275000
CHEMICAL NAME :
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro- 3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-
CAS REGISTRY NUMBER :
914-00-1
LAST UPDATED :
199506
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C22-H22-N2-O8
MOLECULAR WEIGHT :
442.46
WISWESSER LINE NOTATION :
L E6 C666 BV FV MY CU GU LHTT&&J DQ EQ GVZ HQ IN1&1 KQ MU1 RQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
660 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
3750 ug/L
REFERENCE :
BCPHBM British Journal of Clinical Pharmacology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1974- Volume(issue)/page/year: 16,127,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1538 No. of Facilities: 11 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1150 (estimated) No. of Female Employees: 591 (estimated)
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