(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol,(2R,3R)-2,3-dihydroxybutanedioic acid

(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol,(2R,3R)-2,3-dihydroxybutanedioic acid 基本信息
CAS号 5965-13-9 分子式 C22H29NO9
分子量 451.46700 精确质量 　451.18400
PSA 　156.99000 LogP 　-0.45960
我要卖该产品 我要采购该产品

等价的CAS号：

4030-55-1,5965-13-9,6414-38-6,13463-46-2
充值推广 查看更多供应商
目录
基本信息 物化性质 毒性

基本信息 展开↓

CAS号：
5965-13-9
3D弹球模型：
立即前往扯扯看
分子式：
C22H29NO9
分子量：
451.46700
英文名称：
(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol,(2R,3R)-2,3-dihydroxybutanedioic acid
英文别名：
(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol,(2R,3R)-2,3-dihydroxybutanedioic acid;
Dihydrocodein-hydrogentartrat;
Paracodeine bitartrate;
Dihydrocodeine Bitartrate [USP];
Tuscodin;
dihydrocodeine tartrate;
DF 118;
Dihydrocodeine bitartrate;
Dihydrocodeine acid tartrate
精确分子量/精确质量：
451.18400
极性分子表面积/PSA：
156.99000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
InChI：
The Key: ZGSZBVAEVPSPFM-FFHNEAJVSA-N

物化性质展开↓

密度：
1.31 g/cm3
沸点：
462ºC at 760 mmHg
闪点：
233.2ºC

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QD1729000
CAS REGISTRY NUMBER :
5965-13-9
LAST UPDATED :
199712
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C18-H23-N-O3.C4-H6-O6
MOLECULAR WEIGHT :
451.52
WISWESSER LINE NOTATION :
T B6566 B6/CO 4ABBC R BX HO PN GHT&&TTJ FQ JO1 P1 &OVYQYQVO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human
DOSE/DURATION :
357 ug/kg/5M-C
TOXIC EFFECTS :
Behavioral - irritability
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,1425,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
359 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,42,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
252 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness Behavioral - analgesia
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 136,333,1962
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 51,35,1934
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
142 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 66,182,1939
立即下载安装“化学加”APP
专业、功能强大，随时调用更加方便
下载APP