R-(-)-5-(2-氨基丙基)-2-甲氧基苯磺酰胺

R-(-)-5-(2-氨基丙基)-2-甲氧基苯磺酰胺 基本信息
CAS号 112101-81-2 分子式 C10H15NO4S
分子量 245.29500 精确质量  245.07200
PSA  98.00000 LogP  2.04700

基本信息 展开↓

CAS号:
112101-81-2
3D弹球模型:
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分子式:
C10H15NO4S
分子量:
245.29500
中文名称:
R-(-)-5-(2-氨基丙基)-2-甲氧基苯磺酰胺
英文名称:
R-(-)-5-(2-Amino-propyl)-2-methoxy-benzenesulfonamide
中文别名:
R-(-)-5-(2-氨基丙基)-2-甲氧基苯磺酰胺
英文别名:
R-(-)-5-(2-Amino-propyl)-2-methoxy-benzenesulfonamide;
R-(-)-5-2(2-AMinopropyl)-2-MethoxybenzenesulfonaMide;
R-(-)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide;
R(-)-5-[(2-amino-2-methyl)ethyl]-2-methoxy benzenesulfonamide;
(2R)-2-amino-1-(4-methoxy-3-sulfamoylphenyl)propane;
Aminopropyl)-2-methoxybenzene sulfonamide;
5-[(R)-(2-aminopropyl)]-2-methoxybenzene;
(R)-1-methyl-2-(3-aminosulfonyl-4-methoxyphenyl)ethylamine;
5-[(2R)2-2Aminopropyl]-2-MethoxyBenzeneSulfonamide;
(R)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide;
R-(-)-5-[2(2-AMINO-2-METHYL)ETHYL]-2-METHORY BENZENE SULFONAMIDE;
5-((2R)-2-AMINOPROPYL)-2-METHOXYBENZENESULFONAMIDE (INTERMEDIATE OF TAMSULOSIN);
5-[(2R)-2-aminopropyl]-2-methoxybenzenesulfonamide
精确分子量/精确质量:
245.07200
极性分子表面积/PSA:
98.00000
油水分配系数/LogP:

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值,反映了物质在油水两相中的分配情况。其中、LogP值越大,说明该物质越亲油;反之,LogP值越小,则说明该物质越亲水。
InChI:
InChI=1/C10H13NO4S/c1-7(12)5-8-3-4-9(15-2)10(6-8)16(11,13)14/h3-4,6H,5H2,1-2H3,(H2,11,13,14)

生产制备方法及用途展开↓

制备方法


坦索罗辛中间体。

用途简介


物化性质展开↓

密度:
1.288g/cm3
熔点:
276-278ºC
沸点:
444.618ºC at 760 mmHg
闪点:
222.697ºC
折射率:
1.543
蒸汽压:
0mmHg at 25°C

安全信息展开↓

海关代码:
2935009090

合成路线查看所有的合成路线

  • 842130-16-9

    (R)-2-(N-(trifluoroacetyl)arnino)-1-(4'-methoxy-3'-sulphamoyl)-phenylpropane

  • ~86%

  • 112101-81-2

    R-(-)-5-(2-氨基丙基)-2-甲氧基苯磺酰胺

  • 906338-31-6

    906338-31-6

  • ~85%

  • 112101-81-2

    R-(-)-5-(2-氨基丙基)-2-甲氧基苯磺酰胺

  • 957777-99-0

    957777-99-0

  • ~84%

  • 112101-81-2

    R-(-)-5-(2-氨基丙基)-2-甲氧基苯磺酰胺

MSDS 展开↓

Name: (R)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide Material Safety Data Sheet
Synonym:
CAS: 112101-81-2
Section 1 - Chemical Product   MSDS Name:(R)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide Material Safety Data Sheet
Synonym:

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
112101-81-2 (R)-5-(2-Aminopropyl)-2-methoxybenzene unlisted
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
  Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 112101-81-2: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Solid
Color: white to light yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 168 - 172 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C10H16N2O3S
Molecular Weight: 244.31

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Not available.
Conditions to Avoid:
Not available.
Incompatibilities with Other Materials:
Not available.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 112101-81-2 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
(R)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION
 

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 112101-81-2: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 112101-81-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 112101-81-2 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

海关数据查看详细

中国海关编码:2935009090

概述:
2935009090 其他磺(酰)胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
申报要素:
品名, 成分含量, 用途
摘要/Summary:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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