苯唑西林钠

苯唑西林钠 基本信息
CAS号 1173-88-2 分子式 C19H18N3NaO5S
分子量 423.41800 精确质量 　423.08600
PSA 　140.87000 LogP 　0.88940
我要卖该产品 我要采购该产品

等价的CAS号：

1173-88-2,86555-26-2
充值推广 查看更多供应商
目录
基本信息 制备方法与用途 物化性质 安全信息 合成路线 毒性 上下游

基本信息 展开↓

CAS号：
1173-88-2
3D弹球模型：
立即前往扯扯看
分子式：
C19H18N3NaO5S
分子量：
423.41800
中文名称：
苯唑西林钠
英文名称：
oxacillin sodium
中文别名：
苯唑西林钠;
(2S,5R,6R)-3,3-二甲基-6-[(5-甲基-3-苯基-1,2-恶唑-4-甲酰)氨基]-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-羧酸钠盐;
新青霉素Ⅱ
英文别名：
oxacillin sodium;
OXACILLIN SODIUM;
Oxacillin sodium salt
精确分子量/精确质量：
423.08600
极性分子表面积/PSA：
140.87000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
贝尔斯坦号/MDL：
MFCD00082382
EINECS：
214-636-3
PubChem：
24857028
BRN：
4098179
InChI：
The Key: VDUVBBMAXXHEQP-SLINCCQESA-M

生产制备方法及用途展开↓

制备方法

用于抗青霉素葡萄球菌引起的肺炎和皮肤、软组织感染等。

用途简介

用途

1.对耐青霉素的金葡菌有杀菌作用

物化性质展开↓

外观与性状：
结晶
密度：
1.49g/cm3
熔点：
188ºC
沸点：
686.8ºC at 760 mmHg
闪点：
369.2ºC
蒸汽压：
8.32E-20mmHg at 25°C
存储条件/存储方法：

2-8°C

其它信息：

1.熔点（ºC）：188

安全信息展开↓

海关代码：
2941109900
安全说明：
S22-S24/25
安全标志：
S22:不要吸入粉尘。
S24/25:防止皮肤和眼睛接触。
危险标志：
Xi: Irritant;

合成路线查看所有的合成路线

  • 551-16-6

    6-氨基青霉烷酸

  • +

  • 16883-16-2

    5-甲基-3-苯基-4-异唑甲酰氯

  • →

  • 1173-88-2

    苯唑西林钠

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XH9100000
CHEMICAL NAME :
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-6-(5-methyl-3-phenyl- 4-isoxazolecarboxamido)-7-oxo-, monosodium salt
CAS REGISTRY NUMBER :
1173-88-2
LAST UPDATED :
199707
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C19-H18-N3-O5-S.Na
MOLECULAR WEIGHT :
423.45
WISWESSER LINE NOTATION :
T45 ANV ESTJ F1 F1 GVQ CMV- DT5NOJ C1 ER &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
4560 mg/kg/11W-I
TOXIC EFFECTS :
Liver - other changes Musculoskeletal - other changes
REFERENCE :
RMMJAK Rocky Mountain Medical Journal. (Denver, Co) V.35-76, 1938-79. Volume(issue)/page/year: 62,34,1965
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human
DOSE/DURATION :
1200 mg/kg/7D
TOXIC EFFECTS :
Liver - liver function tests impaired
REFERENCE :
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 138,915,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,147,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 15,322,1965
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,147,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2150 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,147,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,147,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,147,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1399 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 31,232,1968
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
>750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 15,322,1965 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4485 No. of Facilities: 151 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 3615 (estimated) No. of Female Employees: 2410 (estimated)

上下游相关产品

上游产品

更多

  • 551-16-6

    6-氨基青霉烷酸

  • 16883-16-2

    5-甲基-3-苯基-4-异唑甲酰氯

立即下载安装“化学加”APP
专业、功能强大，随时调用更加方便
下载APP