3-氯-2-氰基吡啶

3-氯-2-氰基吡啶 基本信息
CAS号 38180-46-0 分子式 C6H3ClN2
分子量 138.55400 精确质量  137.99800
PSA  36.68000 LogP  1.60668

基本信息 展开↓

CAS号:
38180-46-0
3D弹球模型:
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分子式:
C6H3ClN2
分子量:
138.55400
中文名称:
3-氯-2-氰基吡啶
英文名称:
3-Chloro-2-cyanopyridine
中文别名:
3-氯-2-氰基吡啶;
3-氯吡啶-2-甲腈;
3-氯氰基吡啶;
2-氰基-3-氯吡啶;
3-氯-2-氰吡啶;
2-腈基-3-氯吡啶;
2氰基-3-氯吡啶;
3-氯-2-吡啶甲腈
英文别名:
3-Chloro-2-cyanopyridine;
2-Cyano-3-Chloropyridine;
2-Cyano-3-chloropyridine;
3-Chloro-2-pyridinecarbonitrile;
3-Chloropicolinonitrile
精确分子量/精确质量:
137.99800
极性分子表面积/PSA:
36.68000
油水分配系数/LogP:

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值,反映了物质在油水两相中的分配情况。其中、LogP值越大,说明该物质越亲油;反之,LogP值越小,则说明该物质越亲水。
InChI:
InChI=1/C6H3ClN2/c7-5-2-1-3-9-6(5)4-8/h1-3H

物化性质展开↓

密度:
1.33g/cm3
熔点:
81-83°C
沸点:
260.7ºC at 760 mmHg
闪点:
111.4ºC
折射率:
1.565
存储条件/存储方法:

 密封、阴凉、干燥保存

稳定性相关:

常规情况下不会分解,没有危险反映

其它信息:

1.       性状:粉末

2.       密度(g/mL,20 ºC):未确定

3.       相对蒸汽密度(g/mL,空气=1): 未确定

4.       熔点(ºC):84-85

5.       沸点(ºC,1.1 kPa):未确定

6.       沸点(ºC,10mm hg):未确定

7.       折射率:未确定

8.       闪点(ºC):未确定

9.       比旋光度(º):未确定

10.    自燃点或引燃温度(ºC): 未确定

11.    蒸气压(kPa,25ºC):未确定

12.    饱和蒸气压(kPa,60ºC): 未确定

13.    燃烧热(KJ/mol):未确定

14.    临界温度(ºC):未确定

15.    临界压力(KPa):未确定

16.    油水(辛醇/水)分配系数的对数值:未确定

17.    爆炸上限(%,V/V):未确定

18.    爆炸下限(%,V/V):未确定

19.    溶解性:未确定

安全信息展开↓

危险标志:
T,Xi

合成路线查看所有的合成路线

  • 1851-22-5

    3-氯吡啶 N-氧化物

  • +

  • 7677-24-9

    三甲基氰硅烷

  • ~98%

  • 38180-46-0

    3-氯-2-氰基吡啶

  • 1851-22-5

    3-氯吡啶 N-氧化物

  • +

  • 7677-24-9

    三甲基氰硅烷

  • ~83%

  • 89809-64-3

    5-氯-2-氰基吡啶

  • +

  • 38180-46-0

    3-氯-2-氰基吡啶

  • 100-70-9

    2-氰基吡啶

  • ~75%

  • 38180-46-0

    3-氯-2-氰基吡啶

毒理性展开↓

生态数据:

对水是稍微有危害的不要让未稀释或大量的产品接触地下水、水道或者污水系统,若无政府许可,勿将材料排入周围环境。

MSDS 展开↓

  Material Safety Data Sheet

Section 1. Identification of the substance
    Product Name:      3-Chloro-2-cyanopyridine    
    Synonyms:

Section 2. Hazards identification
    Harmful by inhalation, in contact with skin, and if swallowed.
    H311:        Toxic in contact with skin    
    H302:        Harmful if swallowed    
    H332:        Harmful if inhaled    
    H315:        Causes skin irritation    
    Causes serious eye irritation
    H319:
    H335:        May cause respiratory irritation    
    P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
    and easy to do – continue rinsing
    P309:        IF exposed or you feel unwell:    
    P310:        Immediately call a POISON CENTER or doctor/physician    

Section 3. Composition/information on ingredients.
    Ingredient name:        3-Chloro-2-cyanopyridine    
    CAS number:        38180-46-0    

Section 4. First aid measures
    Skin contact:        Immediately wash skin with copious amounts of water for at least 15 minutes while removing    
    contaminated clothing and shoes. If irritation persists, seek medical attention.
    Eye contact:        Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate    
    flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
    attention.
    Inhalation:        Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.    
    Ingestion:        Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.    

Section 5. Fire fighting measures
    In the event of a fire involving this material, alone or in combination with other materials, use dry
    powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
    should be worn.

Section 6. Accidental release measures
    Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
    standards.
    Respiratory precaution:        Wear approved mask/respirator    
    Hand precaution:        Wear suitable gloves/gauntlets    
    Skin protection:        Wear suitable protective clothing    
    Eye protection:        Wear suitable eye protection    
    Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
    for disposal. See section 12.
    Environmental precautions: Do not allow material to enter drains or water courses.

Section 7. Handling and storage
    Handling:        This product should be handled only by, or under the close supervision of, those properly qualified    
    in the handling and use of potentially hazardous chemicals, who should take into account the fire,
    health and chemical hazard data given on this sheet.
    Store in closed vessels.
    Storage:

Section 8. Exposure Controls / Personal protection
    Engineering Controls: Use only in a chemical fume hood.
    Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
    General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section 9. Physical and chemical properties
    Appearance:        Not specified    
    Boiling point:        No data    
    Melting point:        No data    
    Flash point:        No data    
    Density:        No data    
    Molecular formula: C6H3ClN2
    Molecular weight: 138.6

Section 10. Stability and reactivity
    Conditions to avoid: Heat, flames and sparks.
    Materials to avoid: Oxidizing agents.
    Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

Section 11. Toxicological information
    No data.

Section 12. Ecological information
    No data.

Section 13. Disposal consideration
    Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
    disposal authority, in accordance with national and regional regulations.

Section 14. Transportation information
    UN Number:        UN3439        Class: 6.1        Packing group: III    
    Proper shipping name: NITRILES, TOXIC, SOLID, N.O.S. (3-Chloro-2-cyanopyridine)

Section 15. Regulatory information
    No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
    302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
    Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

分子结构与计算化学数据展开↓

计算化学数据


1.疏水参数计算参考值(XlogP):1.5

2.氢键供体数量:0

3.氢键受体数量:2

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积36.7

7.重原子数量:9

8.表面电荷:0

9.复杂度:137

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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