盐酸布比卡因

盐酸布比卡因 基本信息
CAS号 14252-80-3 分子式 C18H29ClN2O
分子量 324.88900 精确质量 　324.19700
PSA 　32.34000 LogP 　4.70940
我要卖该产品 我要采购该产品

等价的CAS号：

14252-80-3,15233-43-9,18010-40-7,27262-46-0,27262-48-2
充值推广 查看更多供应商
目录
基本信息 制备方法与用途 物化性质 安全信息 合成路线 毒性 上下游

基本信息 展开↓

CAS号：
14252-80-3
3D弹球模型：
立即前往扯扯看
分子式：
C18H29ClN2O
分子量：
324.88900
中文名称：
盐酸布比卡因
英文名称：
Bupivacaine Hydrochloride
中文别名：
盐酸布比卡因;
布比卡因盐酸盐;
1-丁基-2-[N-(2,6-二甲基苯胺甲酰基)]哌啶盐酸盐;
2-哌啶甲酰胺,1-丁基-N-(2,6-二甲基苯基)-,盐酸盐;
BUPIVACAINE 盐酸盐
英文别名：
Bupivacaine Hydrochloride;
Bupivacaine hydrochloride
精确分子量/精确质量：
324.19700
极性分子表面积/PSA：
32.34000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
EINECS：
241-917-8
InChI：
The Key: SIEYLFHKZGLBNX-UHFFFAOYSA-N

生产制备方法及用途展开↓

制备方法

左布比卡因为酰胺类局麻药，可以升高神经动作电位的阈值，延缓神经冲动的扩步，降低动作电位升高的速度，从而阻断神经冲动的产生和传导。麻醉作用的产生与神经纤维的轴径、髓鞘形成和传导速度有关。

用途简介

物化性质展开↓

外观与性状：
白色固体
熔点：
249-251ºC
沸点：
423.4ºC at 760 mmHg
闪点：
209.9ºC
蒸汽压：
2.24E-07mmHg at 25°C
存储条件/存储方法：
库房通风低温干燥,与食品原料类分开存放

安全信息展开↓

包装等级：
III
风险类别：
6.1(b)
海关代码：
2942000000
WGK_Germany：
3
德国有关水污染物质的分类清单
危险类别码：
R26/27/28
安全说明：
S22-S36/37/39-S45
RTECS号：
TK6125000
危险标志：
T+:Verytoxic;

合成路线查看所有的合成路线

  • 27262-45-9

    (R)-(+)-丁哌卡因盐酸盐

  • →

    ~97%

  • 14252-80-3

    盐酸布比卡因

  • 14252-80-3

    盐酸布比卡因

  • →

    ~94%

  • 14252-80-3

    盐酸布比卡因

  • 109-65-9

    正溴丁烷

  • →

  • 14252-80-3

    盐酸布比卡因

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TK6125000
CHEMICAL NAME :
2',6'-Pipecoloxylidide, 1-butyl-, hydrochloride, (+-)-
CAS REGISTRY NUMBER :
14252-80-3
LAST UPDATED :
199707
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C18-H28-N2-O.Cl-H
MOLECULAR WEIGHT :
324.94
WISWESSER LINE NOTATION :
T6NTJ A4 BVMR B1 F1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
43 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
58700 ug/kg
TOXIC EFFECTS :
Behavioral - anticonvulsant Behavioral - somnolence (general depressed activity)
REFERENCE :
AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 60,385,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
59 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANPRBG Anesthesia Progress. (Elsevier Science Publishing Co.,Inc., 655 Avenue of the Americas, New York, NY 10010) V.13- 1966- Volume(issue)/page/year: 36,79,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
22753 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 21,277,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
3400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
48 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intratracheal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
11 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,680,1982

上下游相关产品

上游产品

更多

  • 14252-80-3

    盐酸布比卡因

  • 27262-45-9

    (R)-(+)-丁哌卡因盐酸盐

  • 109-65-9

    正溴丁烷

下游产品

更多

  • 14252-80-3

    盐酸布比卡因

立即下载安装“化学加”APP
专业、功能强大，随时调用更加方便
下载APP