cas号： 316-81-4 ，名称：硫丙拉嗪的性质/作用/用途-化学加百科

硫丙拉嗪

硫丙拉嗪基本信息
CAS号	316-81-4	分子式	C22H30N4O2S2
分子量	446.62900	精确质量	446.18100
PSA	80.78000	LogP	4.19870

我要卖该产品我要采购该产品

充值推广查看更多供应商

基本信息物化性质安全信息合成路线毒性海关数据结构与计算数据上下游

基本信息展开↓

CAS号：: 316-81-4
3D弹球模型：: 立即前往扯扯看
分子式：: C22H30N4O2S2
分子量：: 446.62900
中文名称：: 硫丙拉嗪
英文名称：: thioproperazine
中文别名：: 硫丙拉嗪;
N,N-二甲基-10-[3-(4-甲基哌嗪-1-基)丙基]吩噻嗪-2-磺酰胺;
氨砜拉嗪;
磺丙拉嗪
英文别名：: thioproperazine;
2-Dimethylsulfamoyl-10-<3-(4-methyl-piperazin-1-yl)-propyl>-phenothiazin;
10-[3-(4-methyl-piperazin-1-yl)-propyl]-10H-phenothiazine-2-sulfonic acid dimethylamide;
Majeptyl;
Megeptil;
Thioproperazine;
Sulfenazin;
N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide;
10-<3-(4-Methyl-piperazin-1-yl)-propyl>-phenothiazin-2-sulfonsaeure-dimethylamid;
Cephalmin;
Thioperazine;
Mazeptyl;
Thioproperazin;
thiproperazine;
Vontil;
Tioproferazina
精确分子量/精确质量：: 446.18100
极性分子表面积/PSA：: 80.78000
油水分配系数/LogP：: LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
EINECS：: 206-262-4
InChI：: The Key: VZYCZNZBPPHOFY-UHFFFAOYSA-N

物化性质展开↓

密度：: 1.237g/cm3
熔点：: 140ºC
沸点：: 612.2ºC at 760mmHg
闪点：: 324ºC
折射率：: 1.615

安全信息展开↓

海关代码：: 2935009090

合成路线查看所有的合成路线

1217018-61-5

N-(3-chloropropyl)-4-methylpiperazine hydrochloride
+
1090-78-4

N,N-二甲基吩噻嗪-2-磺酰胺
→
316-81-4

硫丙拉嗪

53106-12-0

53106-12-0
→
316-81-4

硫丙拉嗪

53106-13-1

N-[2-[[4-[(二甲氨基)磺基基]-2-硝基苯基]硫代]苯基]甲酰胺
→
316-81-4

硫丙拉嗪

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SP5400000

CHEMICAL NAME :: Phenothiazine-2-sulfonamide, N,N-dimethyl-10-(3-(4-methyl-1-piperazinyl)propyl)-

CAS REGISTRY NUMBER :: 316-81-4

LAST UPDATED :: 199806

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C22-H30-N4-O2-S2

MOLECULAR WEIGHT :: 446.68

WISWESSER LINE NOTATION :: T C666 BN ISJ ESWN1&1 B3- AT6N DNTJ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 830 mg/kg

TOXIC EFFECTS :: Behavioral - antipsychotic

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 200 mg/kg

SEX/DURATION :: female 1-8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 5 mg/kg

REFERENCE :: CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 9(5),14,1975

海关数据查看详细

中国海关编码：2935009090

概述：: 2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%
申报要素：: 品名, 成分含量, 用途
摘要/Summary：: 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

分子结构与计算化学数据展开↓

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:0

3.氢键受体数量:7

4.可旋转化学键数量:6

5.互变异构体数量:无

6.拓扑分子极性表面积:80.8

7.重原子数量:30

8.表面电荷:0

9.复杂度:661

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

上下游相关产品

上游产品

5510-56-5

4-((2-氨基苯基)硫代)-N,N-二甲基-3-硝基苯磺酰胺
53106-13-1

N-[2-[[4-[(二甲氨基)磺基基]-2-硝基苯基]硫代]苯基]甲酰胺
1217018-61-5

N-(3-chloropropyl)-4-methylpiperazine hydrochloride
1090-78-4

N,N-二甲基吩噻嗪-2-磺酰胺