醋酸镍

醋酸镍 基本信息
CAS号 373-02-4 分子式 C2H4O2.1/2Ni
分子量 178.79219 精确质量 　177.97761
PSA 　37.30000 LogP 　0.09090
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等价的CAS号：

373-02-4,14998-37-9,33025-09-1,94044-50-5,98268-31-6
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目录
基本信息 制备方法与用途 物化性质 安全信息 合成路线 化学图谱 毒性 MSDS 海关数据 结构与计算数据 上下游

基本信息 展开↓

CAS号：
373-02-4
3D弹球模型：
立即前往扯扯看
分子式：
C2H4O2.1/2Ni
分子量：
178.79219
中文名称：
醋酸镍
英文名称：
Acetic acid, nickel(2+) salt (2:1)
中文别名：
醋酸镍;
乙酸镍(II)盐;
乙酸镍
英文别名：
Acetic acid, nickel(2+) salt (2:1);
Acetic acid, nickel(2+) salt (8CI,9CI);
Nickel acetate (Ni(OAc)2) (6CI);
Nickel acetate;
Nickel diacetate;
Nickel(2+) acetate;
Nickel(II) acetate;
Nickelous acetate;
Top Seal DX 300;
Top Seal H 298
精确分子量/精确质量：
177.97761
极性分子表面积/PSA：
37.30000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
EINECS：
206-761-7
InChI：
InChI=1/C2H4O2.Ni/c1-2(3)4;/h1H3,(H,3,4);/q;+2/p-1

生产制备方法及用途展开↓

制备方法

制法1 Ni(NO3)2·6H2O+6(CH3CO)2O→Ni(CH3COO)2+2NO2+12O2+10CH3COOH+H2O 6g六水硝酸镍加到35mL醋酸酐中,将此混合物加热至开始激烈反应,再煮沸10min。冷却,吸滤至干,用少量乙酸酐洗涤,再用乙醚洗涤。在真空中于80～90℃干燥。 制法2 Ni(CH3COO)2·4H2O+4(CH3CO) 2O→Ni(CH3COO) 2+8CH3COOH 将15g四水醋酸镍和150mL醋酸酐加热回流16h,分离出来的结晶用醋酸酐洗涤后抽干,置于盛有氢氧化钠固体的真空干燥器中干燥。 也可用碳酸镍与醋酸反应制取。

合成制备方法

制法1     Ni(NO3)2·6H2O+6(CH3CO)2O→Ni(CH3COO)2+2NO2+12O2+10CH3COOH+H2O

6g六水硝酸镍加到35mL醋酸酐中，将此混合物加热至开始激烈反应，再煮沸10min。冷却，吸滤至干，用少量乙酸酐洗涤，再用乙醚洗涤。在真空中于80～90℃干燥。

制法2     Ni(CH3COO)2·4H2O+4(CH3CO) 2O→Ni(CH3COO) 2+8CH3COOH

将15g四水醋酸镍和150mL醋酸酐加热回流16h，分离出来的结晶用醋酸酐洗涤后抽干，置于盛有氢氧化钠固体的真空干燥器中干燥。

也可用碳酸镍与醋酸反应制取。

用途简介

该物用媒染剂,电镀等。

用途

该物用媒染剂，电镀等。

物化性质展开↓

外观与性状：
绿色结晶粉末
密度：
9.50 lb/gal
沸点：
117.1ºC at 760 mmHg
闪点：
40ºC
稳定性相关：

浅绿色柱状结晶，具吸湿性。加热至熔点分解，溶于水，在100g水中溶解度为16.6g。不溶于乙醇。有毒，应密闭保存。

 

安全信息展开↓

海关代码：
2915299090

合成路线查看所有的合成路线

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    醋酸镍

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    [1E,5Z,pR]-1,5-Cyclooctadiene

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    醋酸镍

化学图谱

  1. 醋酸镍红外图谱(IR1)

  2. 醋酸镍红外图谱(IR2)

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毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QR6125000
CAS REGISTRY NUMBER :
373-02-4
LAST UPDATED :
199712
DATA ITEMS CITED :
34
MOLECULAR FORMULA :
C4-H6-O4.Ni
MOLECULAR WEIGHT :
176.81
WISWESSER LINE NOTATION :
QV1 &-NI-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
23 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
410 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
32 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1581 mg/kg/6W-C
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - changes in iron Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25297 mg/kg/4W-C
TOXIC EFFECTS :
Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15912 ug/kg female 16-18 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Endocrine - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
420 mg/kg/47W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
95 mg/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
360 mg/kg/8W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
225 mg/kg/46W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15912 ug/kg female 17 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Endocrine - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
10 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
Unscheduled DNA synthesis

MUTATION DATA

TYPE OF TEST :
Morphological transformation
TEST SYSTEM :
Rodent - hamster Kidney
REFERENCE :
IAPUDO IARC Publications. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.27- 1979- Volume(issue)/page/year: 53,193,1984 *** REVIEWS *** ACGIH TLV-TWA 0.1 mg(Ni)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,264,1987 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 49,257,1990 TOXICOLOGY REVIEW ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued. Volume(issue)/page/year: 5,51,1972 TOXICOLOGY REVIEW 85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: Ni,168,1975 TOXICOLOGY REVIEW ACLSCP Annals of Clinical and Laboratory Science. (1833 Delancey Pl., Philadelphia, PA 19103) V.1- 1971- Volume(issue)/page/year: 3,156,1973 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 1 mg(Ni)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,178,1971 OSHA PEL (Gen Indu):8H TWA 1 mg(Ni)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 1 mg(Ni)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 1 mg(Ni)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 1 mg(Ni)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO NICKEL, INORGANIC-air:10H CA TWA 0.015 mg(Ni)/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81906 No. of Facilities: 128 (estimated) No. of Industries: 6 No. of Occupations: 13 No. of Employees: 2489 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81906 No. of Facilities: 481 (estimated) No. of Industries: 18 No. of Occupations: 12 No. of Employees: 6772 (estimated) No. of Female Employees: 281 (estimated)

MSDS 展开↓

Name: Nickel (II) acetate Material Safety Data Sheet
Synonym: Acetic acid, Nickel (II) salt; Nickelous acetat
CAS: 373-02-4
Section 1 - Chemical Product   MSDS Name:Nickel (II) acetate Material Safety Data Sheet
Synonym:Acetic acid, Nickel (II) salt; Nickelous acetat
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
373-02-4 Nickel(ii) acetate 206-761-7
Hazard Symbols: XN
Risk Phrases: 20/22
Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Harmful by inhalation and if swallowed.Carcinogen.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation:
May cause respiratory tract irritation.
Chronic:
May cause cancer according to animal studies. May cause reproductive and fetal effects.
Section 4 - FIRST AID MEASURES
  Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower lids. Get medical aid immediately.
Skin:
Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.
Autoignition Temperature: Not available.
Flash Point: Not available.
NFPA Rating: Not published.
Explosion Limits, Lower: Not available.
Upper: Not available.
Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Wash area with soap and water. Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Use with adequate ventilation.
Storage:
Store in a cool, dry place.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134. Always use a NIOSH-approved respirator when necessary.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Solid
Appearance: green
Odor: None reported
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Decomposition Temperature: Not available.
Solubility: Soluble in water.
Specific Gravity/Density: 1.798
Molecular Formula: C4H6O4Ni
Molecular Weight: 176.7296
Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
None reported.
Incompatibilities with Other Materials:
None reported.
Hazardous Decomposition Products:
Irritating and toxic fumes and gases.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 373-02-4: QR6125000 LD50/LC50:
CAS# 373-02-4: Oral, mouse: LD50 = 410 mg/kg; Oral, rat: LD50 = 350 mg/kg.
Carcinogenicity:
Nickel(ii) acetate - NTP: Suspect carcinogen OSHA: Possible Select carcinogen See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
  For further information, contact Fisher Scientific.
Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
 
CDG/CPL
IMO
No information available.
IATA
No information available.
RID/ADR
No information available.
Canadian TDG
No information available.
Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 20/22 Harmful by inhalation and if swallowed.
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 373-02-4:
Canada
CAS# 373-02-4 is listed on Canada's DSL/NDSL List.
WHMIS: Not available.
CAS# 373-02-4 is listed on Canada's Ingredient Disclosure List.
Exposure Limits
US FEDERAL
TSCA
CAS# 373-02-4 is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION
N/A

海关数据查看详细

中国海关编码：2915299090

概述：
HS: 2915299090 其他乙酸盐 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 增值税率:17.0% 最惠国关税:5.5% 普通关税:50.0%
申报要素：
品名, 成分含量, 用途
监管条件：
A.入境货物通关单B.出境货物通关单
检验检疫：
R.进口食品卫生监督检验S.出口食品卫生监督检验M.进口商品检验N.出口商品检验
摘要/Summary：
2915299090 salts of acetic acid。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:50.0%

分子结构与计算化学数据展开↓

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:0

3.氢键受体数量:4

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积80.3

7.重原子数量:9

8.表面电荷:0

9.复杂度:25.5

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:3

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