L-γ-Glutamyl-3-[(1R)-2-methylenecyclopropyl]alanine

L-γ-Glutamyl-3-[(1R)-2-methylenecyclopropyl]alanine 基本信息
CAS号 502-37-4 分子式 C12H18N2O5
分子量 270.28200 精确质量 　270.12200
PSA 　133.21000 LogP 　1.25470
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目录
基本信息 物化性质 合成路线 毒性 上下游

基本信息 展开↓

CAS号：
502-37-4
3D弹球模型：
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分子式：
C12H18N2O5
分子量：
270.28200
英文名称：
L-γ-Glutamyl-3-[(1R)-2-methylenecyclopropyl]alanine
英文别名：
L-γ-Glutamyl-3-[(1R)-2-methylenecyclopropyl]alanine;
Hypoglyin-B;
(S)-2-L-alanylamino-butyric acid;
(S)-2-L-Alanylamino-buttersaeure;
L-2-(L-2-Amino-propionylamino)-buttersaeure;
N-L-Alanyl-L-2-amino-buttersaeure
精确分子量/精确质量：
270.12200
极性分子表面积/PSA：
133.21000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
InChI：
The Key: UYDZYCPIQSRXKU-NPPUSCPJSA-N

物化性质展开↓

密度：
1.33g/cm3
沸点：
592.8ºC at 760mmHg
闪点：
312.3ºC
折射率：
1.562

合成路线查看所有的合成路线

  • 80514-73-4

    (2S)-2-(tritylamino)pentanedioic acid

  • →

  • 502-37-4

    L-γ-Glutamyl-3-[(1R)-2-methylenecyclopropyl]alanine

  • 156-56-9

    (1R,αS)-α-氨基-2-亚甲基环丙烷丙酸

  • →

  • 502-37-4

    L-γ-Glutamyl-3-[(1R)-2-methylenecyclopropyl]alanine

  • 45214-61-7

    N-trifluoroacetyl-L-glutamic acid-1-ethyl ester

  • →

  • 502-37-4

    L-γ-Glutamyl-3-[(1R)-2-methylenecyclopropyl]alanine

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AY6330000
CHEMICAL NAME :
Alanine, N-L-gamma-glutamyl-3-(methylenecyclopropyl)-
CAS REGISTRY NUMBER :
502-37-4
BEILSTEIN REFERENCE NO. :
3162184
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C12-H18-N2-O5
MOLECULAR WEIGHT :
270.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 121,272,1957
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 121,272,1957
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Endocrine - hypoglycemia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 121,272,1957 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intrauterine
DOSE :
500 ug/kg
SEX/DURATION :
female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 4,246,1971

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