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Section 1. Chemical Product and Company Identification
    L-Norepinephrine
    Common Name/
    Trade Name
    L-Norepinephrine

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Section 3. Hazards Identification
    Potential Acute Health Effects Very hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant),
    of inhalation. Severe over-exposure can result in death.
    Potential Chronic Health Effects        CARCINOGENIC EFFECTS: Not available.    
    MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast.
    TERATOGENIC EFFECTS: Not available.
    DEVELOPMENTAL TOXICITY: Not available.
    The substance is toxic to cardiovascular system.
    The substance may be toxic to muscle tissue.
    Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure to a
    highly toxic material may produce general deterioration of health by an accumulation in one or many human
    organs.

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Section 4. First Aid Measures
    Eye Contact        Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at    
    least 15 minutes. Get medical attention if irritation occurs.
    Skin Contact        Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.    
    Not available.
    Serious Skin Contact
    If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
    Inhalation
    Get medical attention.
    Serious Inhalation        Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or    
    waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth
    resuscitation. Seek medical attention.
    Ingestion        If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by    
    mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical
    attention immediately.
    Serious Ingestion        Not available.    

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Section 5. Fire and Explosion Data
    Flammability of the Product        May be combustible at high temperature.    
    Not available.
    Auto-Ignition Temperature
    Not available.
    Flash Points
    Not available.
    Flammable Limits
    These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
    Products of Combustion
    Slightly flammable to flammable in presence of heat.
    Fire Hazards in Presence of
    Various Substances
    Explosion Hazards in Presence of Risks of explosion of the product in presence of mechanical impact: Not available.
    Various Substances        Risks of explosion of the product in presence of static discharge: Not available.    
    SMALL FIRE: Use DRY chemical powder.
    Fire Fighting Media
    LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
    and Instructions
    As with most organic solids, fire is possible at elevated temperatures
    Special Remarks on
    Fire Hazards
    Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust
    Special Remarks on Explosion
    explosion hazard.
    Hazards
    L-Norepinephrine

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Section 6. Accidental Release Measures
    Use appropriate tools to put the spilled solid in a convenient waste disposal container.
    Small Spill
    Poisonous solid.
    Large Spill
    Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray to
    reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition

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Section 7. Handling and Storage
    Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
    Precautions
    ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and
    show the container or the label. Keep away from incompatibles such as oxidizing agents, acids, alkalis.
    Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above -20°C (-4°F).
    Storage
    Freeze.

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Section 8. Exposure Controls/Personal Protection
    Engineering Controls        Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below    
    recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
    airborne contaminants below the exposure limit.
    Personal Protection        Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.    
    Gloves.
    Personal Protection in Case of a Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
    Large Spill        to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist    
    BEFORE handling this product.
    Exposure Limits        Not available.    

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Section 9. Physical and Chemical Properties
    Physical state and appearance Solid. (Crystalline solid. Crystalline powder.)        Not available.    
    Odor
    Taste        Not available.    
    Molecular Weight        169.18 g/mole    
    Off-white.
    Color
    Not available.
    pH (1% soln/water)
    Not available.
    Boiling Point
    Melting Point        220°C (428°F)    
    Critical Temperature        Not available.    
    Not available.
    Specific Gravity
    Not applicable.
    Vapor Pressure
    Vapor Density        Not available.    
    Not available.
    Volatility
    Not available.
    Odor Threshold
    Water/Oil Dist. Coeff.        Not available.    
    Ionicity (in Water)        Not available.    
    Not available.
    Dispersion Properties
    Not available.
    Solubility
    L-Norepinephrine

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Section 10. Stability and Reactivity Data
    The product is stable.
    Stability
    Instability Temperature        Not available.    
    Conditions of Instability        Excess heat, incompatible materials    
    Reactive with oxidizing agents, acids, alkalis.
    Incompatibility with various
    substances
    Not available.
    Corrosivity
    Not available.
    Special Remarks on
    Reactivity
    Not available.
    Special Remarks on
    Corrosivity
    Polymerization        Will not occur.    

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Section 11. Toxicological Information
    Routes of Entry        Inhalation. Ingestion.    
    Toxicity to Animals        Acute oral toxicity (LD50): 20 mg/kg [Mouse].    
    Chronic Effects on Humans        MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast.    
    Causes damage to the following organs: cardiovascular system.
    May cause damage to the following organs: muscle tissue.
    Other Toxic Effects on Humans Very hazardous in case of ingestion.
    Slightly hazardous in case of skin contact (irritant), of inhalation.
    Special Remarks on        Not available.    
    Toxicity to Animals
    Human: passes the placental barrier.
    Special Remarks on
    May cause adverse reproductive effects and birth defects (teratogenic).
    Chronic Effects on Humans
    May affect genetic material (mutagenic)
    Acute Potential Health Effects:
    Special Remarks on other Toxic
    Skin: May cause skin irritation.
    Effects on Humans
    Eyes: May cause eye irritation.
    Inhalation: Dust may cause respiratory tract irritation.
    Ingestion: May be fatal if swallowed. May cause nausea, vomiting, and hypersalivation. Affects the
    cardiovascular system/heat (hypertension, dradycardia, arrhythmias, anginal pain, palpitations, cardiac arrest,
    sudden death. May affect metabolism (altered glucose metabolism). May affect the blood (aggregated pltelets
    and occlusive platelet thrombi), behavior/central nervous system (fear, anxiety, restlessness, tremor, insomnia,
    somnolence, muscle weakness, confusion, irritability, weakness, psychosis), kidneys (nephrotoxicity), respiration
    (dyspnea).

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Section 12. Ecological Information
    Ecotoxicity        Not available.    
    BOD5 and COD        Not available.    
    Possibly hazardous short term degradation products are not likely. However, long term degradation products may
    Products of Biodegradation
    arise.
    The products of degradation are less toxic than the product itself.
    Toxicity of the Products
    of Biodegradation
    Not available.
    Special Remarks on the
    Products of Biodegradation
    L-Norepinephrine

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Section 13. Disposal Considerations
    Waste Disposal        Waste must be disposed of in accordance with federal, state and local environmental    
    control regulations.

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Section 14. Transport Information
    DOT Classification        CLASS 6.1: Poisonous material.    
    UNNA: 2811 : Toxic solid, organic, n.o.s(L-Norepinephrine) PG: II
    Identification
    Not available.
    Special Provisions for
    Transport
    DOT (Pictograms)

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Section 15. Other Regulatory Information and Pictograms
    Federal and State        No products were found.    
    Regulations
    California        California prop. 65: This product contains the following ingredients for which the State of California has found to    
    cause cancer which would require a warning under the statute: No products were found.
    Proposition 65
    Warnings
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    cause birth defects which would require a warning under the statute: No products were found.
    OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
    Other Regulations
    EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
    CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC).
    Other Classifications        WHMIS (Canada)    
    DSCL (EEC)        R28- Very toxic if swallowed.        S28- After contact with skin, wash immediately    
    with plenty of water
    S36/37- Wear suitable protective clothing and
    gloves.
    S45- In case of accident or if you feel unwell,
    seek medical advice immediately (show the
    label where possible).
    Health Hazard
    HMIS (U.S.A.)        3 National Fire Protection    
    1 Flammability
    1 Association (U.S.A.)
    Fire Hazard
    3 0 Reactivity
    Health
    Reactivity
    0
    Specific hazard
    Personal Protection
    E
    WHMIS (Canada)
    (Pictograms)
    DSCL (Europe)
    (Pictograms)
    L-Norepinephrine
    TDG (Canada)
    (Pictograms)
    ADR (Europe)
    (Pictograms)
    Protective Equipment
    Gloves.
    Lab coat.
    Dust respirator. Be sure to use an
    approved/certified respirator or equivalent.
    Wear appropriate respirator when
    ventilation is inadequate.

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SECTION 16 - ADDITIONAL INFORMATION
N/A