CHEMICAL IDENTIFICATION

RTECS NUMBER :

SH5455000

CHEMICAL NAME :

Phenethylamine, N,alpha-dimethyl-, hydrochloride, (S)-(+)-

CAS REGISTRY NUMBER :

51-57-0

LAST UPDATED :

199706

DATA ITEMS CITED :

13

MOLECULAR FORMULA :

C10-H15-N.Cl-H

MOLECULAR WEIGHT :

185.72

WISWESSER LINE NOTATION :

1MY1R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

10930 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 253,466,1990

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

15 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,346,1972

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

7560 ug/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 87,214,1946

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

6300 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02170

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

90 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 84,351,1954 ** TUMORIGENIC DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

400 mg/kg female 1-21 day(s) after conception lactating female 19 day(s) post-birth

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis

REFERENCE :

EAGRDS Experimental Aging Research. (Beech Hill Pub. Co., POB 136, Southwest Harbor, ME 04679) V.1- 1975- Volume(issue)/page/year: 5,509,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

792 mg/kg

SEX/DURATION :

male 4 week(s) pre-mating female 4 week(s) pre-mating - 3 week(s) post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :

JONRA9 Journal of Neurochemistry. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) V.1- 1956- Volume(issue)/page/year: 20,625,1973

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

80 mg/kg

SEX/DURATION :

female 13-20 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects Reproductive - Specific Developmental Abnormalities - endocrine system Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :

SYNAET Synapse. (Wiley-Liss, Inc., 605 Third Ave., New York, NY USA 10158-0012) V.1- 1987- Volume(issue)/page/year: 15,198,1993

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

17 mg/kg

SEX/DURATION :

female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :

NHOZAX Nippon Hoigaku Zasshi. Japanese Journal of Legal Medicine. (Nippon Hoi Gakkai, c/o Tokyo Daigaku Igakubu Hoigaku Kyoshitsu, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1944- Volume(issue)/page/year: 46,126,1992

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

19 mg/kg

SEX/DURATION :

female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :

NHOZAX Nippon Hoigaku Zasshi. Japanese Journal of Legal Medicine. (Nippon Hoi Gakkai, c/o Tokyo Daigaku Igakubu Hoigaku Kyoshitsu, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1944- Volume(issue)/page/year: 46,126,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6179 No. of Facilities: 28 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1579 (estimated) No. of Female Employees: 1099 (estimated)