血根碱

血根碱 基本信息
CAS号 5578-73-4 分子式 C20H14ClNO4
分子量 367.78200 精确质量 　367.06100
PSA 　40.80000 LogP 　0.43210
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目录
基本信息 物化性质 安全信息 合成路线 毒性 上下游

基本信息 展开↓

CAS号：
5578-73-4
3D弹球模型：
立即前往扯扯看
分子式：
C20H14ClNO4
分子量：
367.78200
中文名称：
血根碱
英文名称：
sanguinarine chloride
中文别名：
血根碱;
氯化血根碱
英文别名：
sanguinarine chloride;
SANGUINARINE CHLORIDE;
13-methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-13-ium chloride;
chlorure de sanguinarium;
Sanguinarine chloride hydrate;
sanguinarine;
sanguinarium chloride;
13-methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride (1:1)
精确分子量/精确质量：
367.06100
极性分子表面积/PSA：
40.80000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
InChI：
The Key: GIZKAXHWLRYMLE-UHFFFAOYSA-M

物化性质展开↓

熔点：
281-285ºC

安全信息展开↓

WGK_Germany：
3
德国有关水污染物质的分类清单
危险类别码：
22
RTECS号：
VP5220000
危险标志：
Xn

合成路线查看所有的合成路线

  • 548-30-1

    13-methyl-(1,3)Benzodioxolo(5,6-C)-1,3-dioxolo(4,5-I)phenanthridin-14(13H)-one

  • →

    ~99%

  • 5578-73-4

    血根碱

  • 3606-45-9

    二氢血根碱

  • →

    ~83%

  • 5578-73-4

    血根碱

  • 22855-18-1

    22855-18-1

  • →

    ~47%

  • 5578-73-4

    血根碱

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VP5220000
CHEMICAL NAME :
Sanguinarine, chloride
CAS REGISTRY NUMBER :
5578-73-4
LAST UPDATED :
199712
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C20-H14-N-O4.Cl

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1658 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 20,199,1987
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 162,265,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
29 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 20,199,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
102 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 43,161,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 43,161,1981 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
73 mg/kg/1W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 162,265,1948
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2700 ug/kg/2W-C
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 29,199,1987

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