CHEMICAL IDENTIFICATION

RTECS NUMBER :

XH8720000

CHEMICAL NAME :

4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(3-(o-chlorophenyl)-S-methyl-4- isoxazolecarboxamido)-3,3-dimethyl-7-oxo-

CAS REGISTRY NUMBER :

61-72-3

LAST UPDATED :

199709

DATA ITEMS CITED :

6

MOLECULAR FORMULA :

C19-H18-Cl-N3-O5-S

MOLECULAR WEIGHT :

435.91

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

429 mg/kg/10D-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - interstitial nephritis Blood - eosinophilia

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

200 mg/kg/5D-I

TOXIC EFFECTS :

Liver - jaundice, other or unclassified Liver - liver function tests impaired

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - child

DOSE/DURATION :

5600 mg/kg/5W-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - interstitial nephritis Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intracerebral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

8100 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

7 gm/kg/4W-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - changes in lung weight Liver - changes in liver weight Endocrine - hypoglycemia

MUTATION DATA

TYPE OF TEST :

Sister chromatid exchange

TEST SYSTEM :

Human Lymphocyte

DOSE/DURATION :

400 mg/L

REFERENCE :

BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927- Volume(issue)/page/year: 60,2143,1984

毒理学数据：

1、急性毒性：男人经口TDLo：429mg/kg/10D-I；女人经口TDLo：200mg/kg/5D-I；小孩经口TDLo：5600mg/kg/5W-I；小鼠经脑 LD50：8100ug/kg

2、其它多剂量毒性：大鼠静脉TDLo：7mg/kg/4W-I

3、致突变性：姐妹染色单体exchangeTEST系统：人类淋巴细胞：400mg/L