[3,4-diacetyloxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl acetate

[3,4-diacetyloxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl acetate 基本信息
CAS号 6742-07-0 分子式 C15H19N3O8
分子量 369.32700 精确质量 　369.11700
PSA 　149.04000 LogP 　-0.26940
我要卖该产品 我要定制合成该产品
充值推广 查看更多供应商
目录
基本信息 物化性质 合成路线 毒性 上下游

基本信息 展开↓

CAS号：
6742-07-0
3D弹球模型：
立即前往扯扯看
分子式：
C15H19N3O8
分子量：
369.32700
英文名称：
[3,4-diacetyloxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl acetate
英文别名：
[3,4-diacetyloxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl acetate;
triacetylcytarabine;
2',3',5'-tri-O-acetyl-arabinofuranosyl-cytidine;
AraC 2',3',5'-tri-O-acetyl ester
精确分子量/精确质量：
369.11700
极性分子表面积/PSA：
149.04000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
InChI：
The Key: YTIZHZPRFYKRIG-RUZUBIRVSA-N

物化性质展开↓

密度：
1.52g/cm3
沸点：
507.4ºC at 760 mmHg
闪点：
260.6ºC
折射率：
1.61

合成路线查看所有的合成路线

  • 25130-27-2

    [3,4-diacetyloxy-5-(2-oxo-4-sulfanylidenepyrimidin-1-yl)oxolan-2-yl]methyl acetate

  • →

    ~90%

  • 6742-07-0

    [3,4-diacetyloxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl acetate

  • 880633-88-5

    tri-O-acetyl-N4-(1-(5-nitrothien-2-yl)ethyl)oxycarbonyl-1-β-D-arabinofuranosylcytosine

  • →

  • 6742-07-0

    [3,4-diacetyloxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl acetate

  • 14057-18-2

    [3,4-diacetyloxy-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl acetate

  • →

  • 6742-07-0

    [3,4-diacetyloxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl acetate

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HA5600000
CHEMICAL NAME :
Cytosine, 1-beta-D-arabino-furanosyl-, 2',3',5'-triacetate
CAS REGISTRY NUMBER :
6742-07-0
LAST UPDATED :
199606
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C15-H19-N3-O8
MOLECULAR WEIGHT :
369.37
WISWESSER LINE NOTATION :
T6NVNJ DZ A- BT5OTJ COV1 DOV1 E1OV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5010 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
680 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg/5D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
750 mg/kg/15D-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Blood - changes in bone marrow (not otherwise specified) Nutritional and Gross Metabolic - body temperature increase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
3 gm/kg/15D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes primarily in glomeruli Blood - thrombocytopenia Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
750 mg/kg/15D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Leukocyte
DOSE/DURATION :
49 umol/L
REFERENCE :
CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 49,2551,1984

上下游相关产品

上游产品

更多

  • 25130-27-2

    [3,4-diacetyloxy-5-(2-oxo-4-sulfanylidenepyrimidin-1-yl)oxolan-2-yl]methyl acetate

  • 6742-08-1

    CAS号：6742-08-1

  • 69-74-9

    盐酸阿糖胞苷

  • 82855-62-7

    4-(1,2,4-triazol-1-yl)-1-(2',3',5'-tri-O-acetyl-β-D-arabinofuranosyl)pyrimidine-2(1H)one

  • 3736-77-4

    2,2'-脱水尿苷

下游产品

更多

  • 147-94-4

    阿糖胞苷

立即下载安装“化学加”APP
专业、功能强大，随时调用更加方便
下载APP