泊非霉素

泊非霉素 基本信息
CAS号 801-52-5 分子式 C16H20N4O5
分子量 348.35400 精确质量 　348.14300
PSA 　127.96000 LogP 　-0.03260
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等价的CAS号：

801-52-5,74707-94-1
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目录
基本信息 物化性质 合成路线 毒性 上下游

基本信息 展开↓

CAS号：
801-52-5
3D弹球模型：
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分子式：
C16H20N4O5
分子量：
348.35400
中文名称：
泊非霉素
英文名称：
Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-,(1aS,8S,8aR,8bS)-
中文别名：
泊非霉素
英文别名：
Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-,(1aS,8S,8aR,8bS)-;
N-methylmitomycin C;
porphiromycin;
Methyl MitoMycin C;
Methylmitomycin;
RegaMycin;
Porfiromycine;
porfiromycin;
8-Azathioxanthine
精确分子量/精确质量：
348.14300
极性分子表面积/PSA：
127.96000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
InChI：
The Key: HRHKSTOGXBBQCB-UHFFFAOYSA-N

物化性质展开↓

密度：
1.52g/cm3
沸点：
560.9ºC at 760 mmHg
闪点：
293ºC
折射率：
1.672

合成路线查看所有的合成路线

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毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CN0525000
CAS REGISTRY NUMBER :
801-52-5
LAST UPDATED :
199709
DATA ITEMS CITED :
19
MOLECULAR FORMULA :
C16-H20-N4-O5
MOLECULAR WEIGHT :
348.40
WISWESSER LINE NOTATION :
T D3 B556 BN EN JV MVTTT&J E1 GO1 H1OVZ KZ L1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human
DOSE/DURATION :
1500 ug/kg
TOXIC EFFECTS :
Blood - leukopenia Blood - thrombocytopenia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
68 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
88660 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
44 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
53500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
55 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Blood - granulocytopenia
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
>10 mg/kg
TOXIC EFFECTS :
Blood - granulocytopenia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
84 mg/kg/28D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
2 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 46,3939,1986

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