CHEMICAL IDENTIFICATION

RTECS NUMBER :

RC8945000

CHEMICAL NAME :

19-Nor-17-alpha-pregna-1,3,5(10)-trien-20-yne-3,17-di ol, 11-beta-methoxy-

CAS REGISTRY NUMBER :

34816-55-2

LAST UPDATED :

199612

DATA ITEMS CITED :

5

MOLECULAR FORMULA :

C21-H26-O3

MOLECULAR WEIGHT :

326.47

WISWESSER LINE NOTATION :

L E5 B666TTT&J CO1 E1 FQ F1UU1 OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Implant

SPECIES OBSERVED :

Rodent - hamster

DOSE/DURATION :

400 mg/kg/39W-C

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

50 ug/kg

SEX/DURATION :

female 16-20 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Effects on Newborn - delayed effects

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

250 ug/kg

SEX/DURATION :

female 16-20 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

1250 ug/kg

SEX/DURATION :

female 16-20 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - live birth index (measured after birth)

MUTATION DATA

TEST SYSTEM :

Rodent - hamster

DOSE/DURATION :

160 mg/kg/20W (Continuous)

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 311,191,1994