(Z)-2-diazonio-1-[(2-hydrazinyl-2-oxoethyl)amino]ethenolate

(Z)-2-diazonio-1-[(2-hydrazinyl-2-oxoethyl)amino]ethenolate 基本信息
CAS号 820-75-7 分子式 C4H7N5O2
分子量 157.13100 精确质量 　157.06000
PSA 　121.61000 LogP 　-1.04374
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基本信息 合成路线 毒性 上下游

基本信息 展开↓

CAS号：
820-75-7
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分子式：
C4H7N5O2
分子量：
157.13100
英文名称：
(Z)-2-diazonio-1-[(2-hydrazinyl-2-oxoethyl)amino]ethenolate
英文别名：
(Z)-2-diazonio-1-[(2-hydrazinyl-2-oxoethyl)amino]ethenolate;
N-Diazoacetyl glycylhydrazide;
N-Diazoacetilglicina-idrazide;
N-Diazoacetyl glycyclhydrazide;
N-Diazoacetyl-glycin-hydrazid;
N-Diazoacetylglycine hydrazide;
Diazoacetylglycine hydrazide;
Diazoacetyl-aminoessigsaeurehydrazid
精确分子量/精确质量：
157.06000
极性分子表面积/PSA：
121.61000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
InChI：
The Key: MOUDDNPBPJHZHZ-UHFFFAOYSA-N

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    (Z)-2-diazonio-1-[(2-ethoxy-2-oxoethyl)amino]ethenolate

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    乙醇

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  • 7803-57-8

    水合肼

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  • 820-75-7

    (Z)-2-diazonio-1-[(2-hydrazinyl-2-oxoethyl)amino]ethenolate

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  • 820-75-7

    (Z)-2-diazonio-1-[(2-hydrazinyl-2-oxoethyl)amino]ethenolate

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MB9450000
CHEMICAL NAME :
Glycine, N-(diazoacetyl)-, hydrazide
CAS REGISTRY NUMBER :
820-75-7
LAST UPDATED :
199703
DATA ITEMS CITED :
17
MOLECULAR FORMULA :
C4-H7-N5-O2
MOLECULAR WEIGHT :
157.16
WISWESSER LINE NOTATION :
ZMV1UNN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1335 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - emphysema Behavioral - muscle contraction or spasticity Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1595 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3852 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2575 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes Liver - other changes Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2985 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - emphysema Cardiac - other changes Gastrointestinal - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
39 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
833 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2100 mg/kg/7D-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in bone marrow (not otherwise specified)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2100 mg/kg/7D-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight Blood - changes in bone marrow (not otherwise specified) Blood - changes in erythrocyte (RBC) count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
780 mg/kg/20D-I
TOXIC EFFECTS :
Gastrointestinal - alteration in gastric secretion Blood - hemorrhage Blood - changes in bone marrow (not otherwise specified)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1080 mg/kg/10D-I
TOXIC EFFECTS :
Behavioral - food intake (animal) Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - proteinuria
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1200 mg/kg/4D-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - leukemia
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
720 mg/kg/4D-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - leukemia

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Rodent - mouse Fibroblast
DOSE/DURATION :
2500 umol/L
REFERENCE :
JCROD7 Journal of Cancer Research and Clinical Oncology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.93- 1979- Volume(issue)/page/year: 94,7,1979

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  • 999-29-1

    (Z)-2-diazonio-1-[(2-ethoxy-2-oxoethyl)amino]ethenolate

  • 64-17-5

    乙醇

  • 7803-57-8

    水合肼

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