美西律

美西律 基本信息
CAS号 31828-71-4 分子式 C11H17NO
分子量 179.25900 精确质量 　179.13100
PSA 　35.25000 LogP 　2.72970
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等价的CAS号：

31828-71-4,61079-93-4,94991-72-7,94991-73-8
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目录
基本信息 物化性质 安全信息 合成路线 毒性 海关数据 上下游

基本信息 展开↓

CAS号：
31828-71-4
3D弹球模型：
立即前往扯扯看
分子式：
C11H17NO
分子量：
179.25900
中文名称：
美西律
英文名称：
mexiletine
中文别名：
美西律;
1-(2,6-二甲基苯氧基)-2-丙胺;
2-溴-4'-碘苯乙酮;
1-Bromo-3-methoxy-2-methylbenzene;
Propionanilide,2-amino-4'-nitro-, monohydrochloride, L- (8CI);
L-Alanine-4-nitroanilidehydrochloride;
L-Alanine-p-nitroanilide hydrochloride;
(S)-2-amino-N-(4-nitrophenyl)propionamide hydrochloride;
(-)-Corey lactone, 4-phenylbenzoate alcohol;
E,Z-9,12-十四碳烯-1-醇乙酸酯;
9,12-(E,Z)-十四碳烯-1-醇乙酸酯;
(反,顺)-9,12-十四碳烯-1-醇乙酸酯;
(Z9,E12)-十四碳烯-1-醇乙酸酯;
Diethyl p-toluene sulfonyl oxymethyl phosphonate;
Diethyl p-toluene sulfonyloxy methyl phosphonate;
diethyl (tosyloxy)methylphosphonate;
Butanoic acid, 4-((4-chlorobenzoyl)(4-methoxyphenyl)amino)- (9CI);
Butyric acid, 4-(p-chloro-N-(p-methoxyphenyl)benzamido)-;
Clanobutin;
2-chloro-2-methylpropanoic acid;
(S)-a-chloropropionic acid;
(S)-2-Chloropropanoic Acid;
S-(-)-2-Chloropropionic Acid;
N-Aminomethyldopa;
NCGC00024596-01;
S(-)-CARBIDOPA;
SMR000058235;
Tocris-0455;
(2S);
S-(-)-carbidopa
英文别名：
mexiletine;
Mexilitene;
Ritalmex;
Olzoron;
ko1173;
Cirumimeru;
MEXILITINE HCL;
1-(2,6-Dimethylphenoxy)-2-propanamine;
Toy;
Ko 1173Cl;
mexitil;
Katen
精确分子量/精确质量：
179.13100
极性分子表面积/PSA：
35.25000
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
EINECS：
250-825-7
InChI：
InChI:1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3

物化性质展开↓

密度：
0.979 g/cm3
熔点：
203-205ºC
沸点：
271.5ºC at 760 mmHg
闪点：
112.2ºC

安全信息展开↓

包装等级：
III
风险类别：
6.1(b)
海关代码：
2922299090
危险类别码：
R20/21/22
安全说明：
S36
危险标志：
Xn: Harmful;

合成路线查看所有的合成路线

  • 53012-41-2

    1-(2,6-二甲基苯氧基)-2-丙酮

  • →

    ~93%

  • 31828-71-4

    美西律

  • 72806-53-2

    1-(2,6-Dimethylphenoxy)-2-azido-propan

  • →

    ~86%

  • 31828-71-4

    美西律

  • 1092493-53-2

    N-BOC-2-(2,6-dimethylphenoxy)-1-methylethylamine

  • →

    ~82%

  • 31828-71-4

    美西律

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KR9300000
CHEMICAL NAME :
Ethylamine, 1-methyl-2-(2,6-xylyloxy)-
CAS REGISTRY NUMBER :
31828-71-4
LAST UPDATED :
199703
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C11-H17-N-O
MOLECULAR WEIGHT :
179.29
WISWESSER LINE NOTATION :
ZY1&1OR B1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
63 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - nausea or vomiting
REFERENCE :
PMESAJ Postgraduate Medical Journal, Supplement. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1949- Volume(issue)/page/year: 53(Suppl 1),134,1977
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
349 mg/kg/4D-I
TOXIC EFFECTS :
Blood - thrombocytopenia
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 100,162,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
41 mg/kg
TOXIC EFFECTS :
Toxic effects not yet reviewed
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5116974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,21,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
114 mg/kg
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 21,370,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
23 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 41,1130,1991

海关数据查看详细

中国海关编码：2922299090

概述：
2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素：
品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
摘要/Summary：
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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