狄氏剂

狄氏剂 基本信息
CAS号 60-57-1 分子式 C12H8Cl6O
分子量 380.91 精确质量 　377.87063
PSA 　12.5 A2 LogP 　4.480±0.461

等价的CAS号：

60-57-1,72-20-8,128-10-9,56816-04-7
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目录
基本信息 制备方法与用途 物化性质 安全信息 合成路线 化学图谱 毒性 MSDS 结构与计算数据 上下游

基本信息 展开↓

CAS号：
60-57-1
3D弹球模型：
立即前往扯扯看
分子式：
C12H8Cl6O
分子量：
380.91
中文名称：
狄氏剂
英文名称：
2,7:3,6-Dimethanonaphth[2,3-b]oxirene, 3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-, (1aR,2R,2aS,3S,6R,6aR,7S,7aS)-rel-
中文别名：
狄氏剂;
1,2,3,4,10,10-六氯-6,7-环氧-1,4,4a,5,6,7,8,8a-八氢-1,4-桥-5,8挂-二甲撑萘;
1,2,3,4,10,10-六氯-1,4,4a,5,6,7,8,8a-八氢-6,7-环氧-1,4:5,8-二甲桥萘;
1,2,3,4,10,10-六氯-6,7-环氧-1,4,4,5,6,7,8,8-八氢-1,4-桥5,8-二亚甲基萘
英文别名：
2,7:3,6-Dimethanonaphth[2,3-b]oxirene, 3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-, (1aR,2R,2aS,3S,6R,6aR,7S,7aS)-rel-;
dieldrin;
(1aR,2R,2aS,3S,6R,6aR,7S,7aS)-3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphth[2,3-b]oxirene;
1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-1,4-endo,endo-5,8-dimethano-naphthaline;
(1aR,2R,2aS,3S,6R,6aR,7S,7aS)-rel-3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphth[2,3-b]oxirene;
(1R,4S,4aS,5R,6R,7S,8S,8aR)-1,2,3,4,10,10-hexachloro-1,4,4a,5,6,7,8,8a-octahydro-6,7-epoxy-1,4:5,8-dimethanonaphthalene;
1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-endo-1,4-exo-5,8-dimethanonaphthalene;
HEOD;
DIELDRIN;
1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-1,4-endo,exo-5,8-dimethanonaphthalene
精确分子量/精确质量：
377.87063
极性分子表面积/PSA：
12.5 A2
油水分配系数/LogP：

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
贝尔斯坦号/MDL：
MFCD00135591
EINECS：
200-484-5
PubChem：
24857518
BRN：
91396
InChI：
The Key: DFBKLUNHFCTMDC-VXFCKWNUSA-N

生产制备方法及用途展开↓

制备方法

由艾氏剂经过过氧乙酸或过氧苯甲酸氧化而得。

合成制备方法

由艾氏剂经过过氧乙酸或过氧苯甲酸氧化而得。

用途简介

狄氏剂为接触性杀虫剂，无内吸性，有一定特效，对大数昆虫有强触杀和胃毒的活性。用作杀虫剂。

用途

1.狄氏剂为接触性杀虫剂，无内吸性，有一定特效，对大数昆虫有强触杀和胃毒的活性。

2.用作杀虫剂。[22]

物化性质展开↓

外观与性状：
白色或淡棕色粉末或晶体
密度：
1.84±0.1 g/cm3
熔点：
174-175 °C
沸点：
416.2±45.0 °C
闪点：
155.3±28.8 °C
水溶解性：
Sparingly Soluble (1.9E-4 g/L)
折射率：
1.676
蒸汽密度：
9.43E-7 Torr
存储条件/存储方法：
库房通风低温干燥,与食品原料分开储运
稳定性相关：

1.稳定性[17]  稳定

2.禁配物[18]  强氧化剂、强酸

3.聚合危害[19]  不聚合

4.分解产物[20]  氯化氢

其它信息：

1.性状：工业品为褐色固体。[1]

2.熔点（℃）：175~177[2]

3.沸点（℃）：330[3]

4.相对密度（水=1）：1.75[4]

5.相对蒸气密度（空气=1）：13.2[5]

6.辛醇/水分配系数：5.4[6]

7.溶解性：不溶于水、甲醇、脂肪烃，溶于丙酮、苯、四氯化碳。[7]

安全信息展开↓

包装等级：
II
风险类别：
6.1(a)
WGK_Germany：
3
德国有关水污染物质的分类清单
危险类别码：
R21/22;R26;R34
安全说明：
22-36/37-45-60-61-36-26-16-62-7
RTECS号：
IO1750000
安全标志：
S22:不要吸入粉尘。
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
S60:本物质残余物和容器必须作为危险废物处理。
S61:避免排放到环境中。参考专门的说明/安全数据表。
:
危险标志：
T,Xn,Xi,F,T+

合成路线查看所有的合成路线

  • 4733-52-2

    2,3-benzodioxine-1,4-dione

  • +

  • 309-00-2

    艾氏剂

  • →

  • 74415-96-6

    endo-6-Chlor-exo-7-trichlormethyl-6,7-dihydro-aldrin

  • +

  • 74415-97-7

    (1R,4S,4aS,5R,5aR,13aS,14S,14aR)-1,2,3,4,16,16-hexachloro-1,4,4a,5,5a,13a,14,14a-octahydro-1,4:5,14-dimethanobenzo[f]naphtho[2,3-b][1,4]dioxocine-7,12-dione

  • 56-23-5

    四氯化碳

  • +

  • 309-00-2

    艾氏剂

  • →

  • 74415-96-6

    endo-6-Chlor-exo-7-trichlormethyl-6,7-dihydro-aldrin

  • +

  • 74415-97-7

    (1R,4S,4aS,5R,5aR,13aS,14S,14aR)-1,2,3,4,16,16-hexachloro-1,4,4a,5,5a,13a,14,14a-octahydro-1,4:5,14-dimethanobenzo[f]naphtho[2,3-b][1,4]dioxocine-7,12-dione

  • 93-59-4

    过氧化氢苯甲酰

  • →

  • 60-57-1

    狄氏剂

化学图谱

  1. 狄氏剂质谱(MS)

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毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
IO1750000
CAS REGISTRY NUMBER :
60-57-1
LAST UPDATED :
199712
DATA ITEMS CITED :
128
MOLECULAR FORMULA :
C12-H8-Cl6-O
MOLECULAR WEIGHT :
380.90
WISWESSER LINE NOTATION :
T E3 D5 C555 A D- FO KUTJ AG AG BG JG KG LG ENDO EXO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human
DOSE/DURATION :
28 mg/kg
TOXIC EFFECTS :
Cardiac - other changes Lungs, Thorax, or Respiration - acute pulmonary edema
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
38300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
13 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
49 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
38 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
26 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intracerebral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema Liver - fatty liver degeneration Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
80 mg/m3/4H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - withdrawal Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
45 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - pig
DOSE/DURATION :
38 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
49 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - pigeon
DOSE/DURATION :
23700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Bird - pigeon
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Behavioral - excitement Behavioral - food intake (animal)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
10780 ug/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - irritability
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - duck
DOSE/DURATION :
381 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
94 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
13300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
75 mg/kg/15D-C
TOXIC EFFECTS :
Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
88 mg/kg/88D-C
TOXIC EFFECTS :
Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
140 mg/kg/8W-I
TOXIC EFFECTS :
Liver - other changes Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
109 mg/kg/2Y-C
TOXIC EFFECTS :
Liver - changes in liver weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
410 mg/kg/39W-C
TOXIC EFFECTS :
Liver - other changes Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75600 ug/kg/18W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - Plasma proteins not involving coagulation
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
840 ug/kg/2W-C
TOXIC EFFECTS :
Immunological Including Allergic - decrease in humoral immune response
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
27200 ug/kg/68W-I
TOXIC EFFECTS :
Liver - changes in liver weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
51 mg/kg/17D-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
751 ug/kg/13W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Immunological Including Allergic - decrease in humoral immune response Biochemical - Metabolism (Intermediary) - other proteins
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
14 mg/kg/14D-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - domestic
DOSE/DURATION :
68 mg/kg/8W-C
TOXIC EFFECTS :
Autonomic Nervous System - sympathomimetic Liver - changes in liver weight Biochemical - Neurotransmitters or modulators (putative) - dopamine at other sites
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
546 mg/kg/65W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
11 gm/kg/3Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
610 mg/kg/73W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
714 mg/kg/85W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4550 mg/kg/65W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
14 ug/kg
SEX/DURATION :
multigenerations
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
30600 ug/kg
SEX/DURATION :
female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
15 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2250 ug/kg
SEX/DURATION :
female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
12500 ug/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
4500 ug/kg
SEX/DURATION :
female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6250 ug/kg
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
219 mg/kg
SEX/DURATION :
female 44 week(s) pre-mating female 1-8 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
30 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
30 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
Morphological transformation
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
DNA inhibition
TYPE OF TEST :
Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Bird - duck Lymphocyte
REFERENCE :
34LXAP "Insecticide Biochemistry and Physiology," Wilkinson, C.F., ed., New York, Plenum Pub. Corp., 1976 Volume(issue)/page/year: -,555,1976 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.25 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 5,125,1974 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 5,125,1974 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,196,1987 TOXICOLOGY REVIEW ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 7,243,1974 TOXICOLOGY REVIEW JSIRAC Journal of Scientific and Industrial Research. (Pub. & Information Directorate, CSIR, Hillside Rd., New Delhi 110012, India) V.1-4, 1942-45; V.22- 1963- Volume(issue)/page/year: 34,462,1975 TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 56,107,1975 TOXICOLOGY REVIEW ECMAAI Economie et Medecine Animales. (Paris, France) V.1-17, 1960-76. Discontinued. Volume(issue)/page/year: 14,141,1973 TOXICOLOGY REVIEW BNYMAM Bulletin of the New York Academy of Medicine. (New York Academy of Medicine, 2 E. 103rd St., New York, NY 10029) Ser 2: V.1- 1925- Volume(issue)/page/year: 54,413,1978 TOXICOLOGY REVIEW 85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971 Volume(issue)/page/year: 5,250,1970 TOXICOLOGY REVIEW 26UZAB "Pesticides Symposia; Collection of Papers Presented at the Sixth & Seventh Inter-American Conferences on Toxicology and Occupational Medicine, Miami, FL," Miami, FL, J.L. Halos, 1968-70 Volume(issue)/page/year: 6,149,1968/1970 TOXICOLOGY REVIEW CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 13,231,1978 TOXICOLOGY REVIEW EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 1,89,1977 TOXICOLOGY REVIEW TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 10,613,1967 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.25 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,84,1971 OSHA PEL (Gen Indu):8H TWA 0.25 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.25 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.25 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.25 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.25 mg/m3;Skin JAN 1993 OEL-AUSTRIA:TWA 0.25 mg/m3;Skin JAN 1993 OEL-BELGIUM:TWA 0.25 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.25 mg/m3;Skin;Carcinogen JAN 1993 OEL-FINLAND:TWA 0.25 mg/m3;STEL 0.75 mg/m3;Skin;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.25 mg/m3;Skin JAN 1993 OEL-GERMANY:TWA 0.25 mg/m3;Skin JAN 1993 OEL-INDIA:TWA 0.25 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.25 mg/m3;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 0.25 mg/m3;Skin JAN 1993 OEL-POLAND:TWA 0.01 mg/m3 JAN 1993 OEL-RUSSIA:STEL 0.01 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.25 mg/m3;Skin JAN 1993 OEL-THAILAND:TWA 0.25 mg/m3 JAN 1993 OEL-TURKEY:TWA 0.25 mg/m3;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 0.25 mg/m3;STEL 0.75 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DIELDRIN-air:CA TWA 0.25 mg/m3 (Sk) (0.15 mg/m3 LOQ) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2830 No. of Facilities: 56 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 760 (estimated)
毒理学数据：

1.急性毒性[8]  LD50：46mg/kg（大鼠经口）

2.刺激性  暂无资料

3.致突变性[9]  微生物致突变性：鼠伤寒沙门菌1mg/L。DNA抑制：人Hela细胞400μmol/L。程序外DNA合成：人成纤维细胞1μmol/L。DNA抑制：人淋巴细胞100mg/L。姐妹染色单体交换：仓鼠卵巢40mg/L。DNA损伤：小鼠成纤维细胞25μmol/L（24h）。

4.致畸性[10]  小鼠孕后6~14d经口给予最低中毒剂量（TDLo）30600μg/kg，致中枢神经系统、眼、耳发育畸形。小鼠孕后6~14d经口给予最低中毒剂量（TDLo）4500μg/kg，致肌肉骨骼系统发育畸形。仓鼠孕后8d经口给予最低中毒剂量（TDLo）30mg/kg，致眼、耳、体壁、颅面部（包括鼻、舌）发育畸形。

5.致癌性[11]  IARC致癌性评论：G3，对人及动物致癌性证据不足。

6.其他[12]   大鼠经口最低中毒剂量（TDLo）：336μg/kg（56d，雄性），影响前列腺、精囊、Copwer腺、附属腺体、尿道、小鼠经口最低中毒剂量（TDLo）：30600μg/kg（孕6~14d），致中枢神经系统、眼、耳发育异常。

生态数据：

1.生态毒性[13]

LC50：0.016mg/L（96h）（黑头呆鱼）；0.008mg/L（96h）（蓝鳃太阳鱼）；0.006mg/L（96h）（大鳞大马哈鱼）；0.25mg/L（48h）（蚤状蚤）

EC50：1.27mg/L（24h）（水蚤）

2.生物降解性[14]

好氧生物降解（h）：4200~25920

厌氧生物降解（h）：24~168

3.非生物降解性[15]  空气中光氧化半衰期（h）：4~40.5

4.生物富集性[16]  BCF：4860~14500（鲤鱼，接触浓度0.001mg/L，接触时间10周）；5390~12500（鲤鱼，接触浓度0.001mg/L，接触时间10周）。

MSDS 展开↓

国标编号: 61876
ＣＡＳ: 60-57-1
中文名称: 狄氏剂
英文名称: Dieldrin
别 名: 六氯-环氧八氢-二甲撑萘 ；化合物-497；Octalox
分子式: C12H8Cl6O
分子量: 380.9
熔 点: 175～176℃
密 度: 1.75
蒸汽压: 25℃
溶解性: 不溶于水，溶于丙酮、苯和四氯化碳等有机溶剂
稳定性: 对酸或碱都稳定
外观与性状: 纯品为白色无臭晶体，工业品为褐色固体
危险标记: 14(有毒品)
用 途: 用作杀虫剂

2.对环境的影响:

一、健康危害

侵入途径：吸入、食入、经皮吸收。 健康危害：对神经系统、肝脏、肾脏有明显的毒性作用。 急性中毒： 可迅速经皮吸收而中毒，症状类似艾氏剂和滴滴涕，蓄积于脂肪中。吸入可引起呼吸道刺激症状；误服中毒可出现头昏恶心、呕吐、全身无力、共济失调、肌肉抽动、震颤、四肝无力、食欲不振、情绪激动等。部分患者可有肝、肾损伤及周围神经炎。

二、毒理学资料及环境行为

毒性：本品属高毒性 。  急性毒性：LD5046mg/kg(大鼠经口)；60mg/kg(大鼠经皮)；LC5043mg/m3，4小时(大鼠吸入)；人经口5mg/kg，最小致死剂量。  致癌性：小鼠经口最小中毒剂量730mg/kg(52周，连续)致癌阳性；大鼠经口最小中毒剂量1.80g/kg(2年，连续)致肿瘤阳性。  致畸性：小鼠经口最小中毒剂量15mg/kg(妊娠期9天)致畸胎阳性。

用作土壤杀虫剂的艾氏剂是环境中狄氏剂(高达97%)的主要来源。艾氏剂和反应产生狄氏剂很快被土壤吸收，特别当土壤含有丰富有机质时，因而几乎不渗透土壤而且通常不发生地下水的沾污。两种化合物的迁移主要经由土壤侵蚀(像随风漂移)和沉积迁移(地表泾流)，而不是通过溶渗。艾氏剂和狄氏剂在农业上使用，产生了土壤中残留物(主要是狄氏剂)，持续期以年计。估计半衰期在4～7年。这些化合物在热带条件下比温带条件下存留期要短。由于处理庄稼和土地，或直接由于杀虫剂的施用，艾氏剂和狄氏剂通过挥发而进入空气。狄氏剂又随水洗刷和干尘降返回到土壤和水表面。因而这些化合物可在气相中测得(很低水平，通常在1～2ng/m3)，或吸附在尘颗粒或降水中(大约10～20ng/l)。  水中生物体对狄氏剂有很高的富集能力，水中很低的含量水平可导致生物体达到有毒的水平。通过水中食物链富集的重要性不及从水中直接的生物吸收。在地球系统中，艾氏剂和狄氏剂以各种形态积累在生物体内，但主要以狄氏剂形式存在。狄氏剂很可能要对田野哺乳动物的死亡和某些物种数量下降(如水獭)负责。

降解：狄氏剂属高毒有机氯杀虫剂，在光照下光解，成光化狄氏剂，毒性更高。

危险特性：遇明火、高热可燃。  燃烧(分解)产物：一氧化碳、二氧化碳、氯化氢。

3.现场应急监测方法:

果蔬类农药残留量的简速检验 薄层色谱法——(姜增武；李宗盈)，《营养学报》，1984，6，No1，55-56(中文)。《分析化学文摘》，1985.1

4.实验室监测方法:

气相色谱法(GB17378.4-1998)(海水)气相色谱法(美国《水和废水标准检验法》)气相色谱法(奶制品、肉类)《农药残留量气相色谱法》国家商检局编

5.环境标准:
前苏联 车间卫生标准 0.01mg/m3(皮)
联合国规划署(1974) 保护水生生物淡水中农药的最大允许浓度 0.005μg/L 
美国EPA规定 饮用水和海产品中浓度上限 不应超过71 pg/l
加工食品中残留允许范围 0～0.1 ppm
6.应急处理处置方法:

一、泄漏应急处理

隔离泄漏污染区，周围设警告标志，切断火源。建议应急处理人员戴好防毒面具，穿化学防护服。不要直接接触泄漏物，小心扫起，置于袋中转移至安全场所。如大量泄漏，收集回收或无害处理后废弃。

二、防护措施

呼吸系统防护：生产操作或农业使用时，应该佩带防毒口罩。紧急事态抢救或逃生时，建议佩带自给式呼吸器。  眼睛防护：可采用安全面罩。  防护服：穿相应的防护服。  手防护：必要时戴防护手套。  其它：工作现场禁止吸烟、进食和饮水。工作后，淋浴更衣。保持良好的卫生习惯。

三、急救措施

皮肤接触：立即脱去污染的衣着，用肥皂水及流动清水彻底冲洗污染的皮肤、头发、指甲等。 眼睛接触：立即提起眼睑，用大量流动清水彻底冲洗。  吸入：迅速脱离现场至空气新鲜处。注意保暖，必要时进行人工呼吸。就医。  食入：患者清醒时给饮大量温水，催吐。可用温水或1∶5000高锰酸钾液彻底洗胃。立即就医。

灭火方法：雾状水、泡沫、二氧化碳、砂土。

分子结构与计算化学数据展开↓

分子结构数据

1、摩尔折射率：77.48

2、摩尔体积（cm3/mol）：205.9

3、等张比容（90.2K）：573.9

4、表面张力（dyne/cm）：60.2

5、极化率（10-24cm3）：30.71

计算化学数据

1、计疏水参数计算参考值（XlogP）：3.7

2、氢键供体数量：0

3、氢键受体数量：1

4、可旋转化学键数量：0

5、互变异构体数量：

6、拓扑分子极性表面积（TPSA）：12.5

7、重原子数量：19

8、表面电荷：0

9、复杂度：516

10、同位素原子数量：0

11、确定原子立构中心数量：8

12、不确定原子立构中心数量：0

13、确定化学键立构中心数量：0

14、不确定化学键立构中心数量：0

15、共价键单元数量：1

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