潘托拉唑钠

潘托拉唑钠 基本信息
CAS号 138786-67-1 分子式 C16H15F2N3O4S.Na
分子量 406.36418 精确质量  406.06491
PSA  94.68000 LogP  3.53580

基本信息 展开↓

CAS号:
138786-67-1
3D弹球模型:
立即前往扯扯看
分子式:
C16H15F2N3O4S.Na
分子量:
406.36418
中文名称:
潘托拉唑钠
英文名称:
1H-Benzimidazole, 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1)
中文别名:
潘托拉唑钠;
5-二氟甲氧基-2-[(3,4-二甲氧基-2-吡啶基)甲基]亚硫酰基-1H-苯骈咪唑钠盐;
泮托拉唑钠;
泮托拉唑钠一水合物
英文别名:
1H-Benzimidazole, 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (9CI);
5-Difluoromethoxy-2-[[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole sodium salt;
Controloc;
Nolpaza;
Pantecta;
Pantoloc;
Pantoprazole sodium;
Pantoprazole sodium salt;
Protonix;
Somac;
Zurcal
精确分子量/精确质量:
406.06491
极性分子表面积/PSA:
94.68000
油水分配系数/LogP:

LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值,反映了物质在油水两相中的分配情况。其中、LogP值越大,说明该物质越亲油;反之,LogP值越小,则说明该物质越亲水。
InChI:
InChI=1/C16H14F2N3O4S.Na/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;/h3-7,15H,8H2,1-2H3;/q-1;+1/rC16H14F2N3NaO4S/c1-24-13-5-6-19-11(14(13)25-2)8-27(23)16-20-10-7-9(26-15(17)18)3-4-12(10)21(16)22/h3-7,15H,8H2,1-2H3

生产制备方法及用途展开↓

制备方法


适用于十二指肠溃疡、胃溃疡急性胃粘膜病变,复合性胃溃疡等急性上消化道出血的治疗。

用途简介


物化性质展开↓

外观与性状:
白色至灰白色固体
熔点:
199-202ºC
沸点:
586.9ºC at 760 mmHg
闪点:
308.7ºC

安全信息展开↓

海关代码:
2933990090
危险类别码:
R20/21/22-37/38-41-48
安全说明:
S22-26-36/37/39-45
危险标志:
Xn:Harmful

合成路线查看所有的合成路线

  • 102625-64-9

    5-(二氟甲氧基)-2-{[(3,4-二甲氧基-2-吡啶基)甲基]硫}-1H-苯并咪唑

  • ~97%

  • 138786-67-1

    潘托拉唑钠

  • 102625-70-7

    潘托拉唑

  • ~95%

  • 138786-67-1

    潘托拉唑钠

  • 97963-62-7

    5-二氟甲氧基-2-巯基-1H-苯并咪唑

  • +

  • 72830-09-2

    2-(氯甲基)-3,4-二甲氧基吡啶盐酸盐

  • ~82%

  • 138786-67-1

    潘托拉唑钠

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DD8264000
CHEMICAL NAME :
1H-Benzimidazole, 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)me thyl)sulfinyl)-, sodium salt
CAS REGISTRY NUMBER :
138786-67-1
LAST UPDATED :
199503
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C16-H14-F2-N3-O4-S.Na
MOLECULAR WEIGHT :
405.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
747 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 15,801,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
256 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 15,801,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 15,801,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
395 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 15,801,1990

MSDS 展开↓

  Material Safety Data Sheet

Section 1. Identification of the substance
    Product Name:      Pantoprazole sodium    
    Synonyms:

Section 2. Hazards identification
    Harmful by inhalation, in contact with skin, and if swallowed.

Section 3. Composition/information on ingredients.
    Ingredient name:        Pantoprazole sodium    
    CAS number:        138786-67-1    

Section 4. First aid measures
    Skin contact:        Immediately wash skin with copious amounts of water for at least 15 minutes while removing    
    contaminated clothing and shoes. If irritation persists, seek medical attention.
    Eye contact:        Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate    
    flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
    attention.
    Inhalation:        Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.    
    Ingestion:        Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.    

Section 5. Fire fighting measures
    In the event of a fire involving this material, alone or in combination with other materials, use dry
    powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
    should be worn.

Section 6. Accidental release measures
    Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
    standards.
    Respiratory precaution:        Wear approved mask/respirator    
    Hand precaution:        Wear suitable gloves/gauntlets    
    Skin protection:        Wear suitable protective clothing    
    Eye protection:        Wear suitable eye protection    
    Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
    for disposal. See section 12.
    Environmental precautions: Do not allow material to enter drains or water courses.

Section 7. Handling and storage
    Handling:        This product should be handled only by, or under the close supervision of, those properly qualified    
    in the handling and use of potentially hazardous chemicals, who should take into account the fire,
    health and chemical hazard data given on this sheet.
    Store in closed vessels.
    Storage:

Section 8. Exposure Controls / Personal protection
    Engineering Controls: Use only in a chemical fume hood.
    Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
    General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section 9. Physical and chemical properties
    Appearance:        Not specified    
    Boiling point:        No data    
    No data
    Melting point:
    Flash point:        No data    
    Density:        No data    
    Molecular formula:        C16H14F2N3NaO4S    
    Molecular weight:        405.4    

Section 10. Stability and reactivity
    Conditions to avoid: Heat, flames and sparks.
    Materials to avoid: Oxidizing agents.
    Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen fluoride, sulfur oxides.

Section 11. Toxicological information
    No data.

Section 12. Ecological information
    No data.

Section 13. Disposal consideration
    Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
    disposal authority, in accordance with national and regional regulations.

Section 14. Transportation information
    Non-harzardous for air and ground transportation.

Section 15. Regulatory information
    No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
    302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
    Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

海关数据查看详细

中国海关编码:2933990090

概述:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素:
品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
摘要/Summary:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

上下游相关产品

上游产品

更多
  • 102625-70-7

    潘托拉唑

  • 102625-64-9

    5-(二氟甲氧基)-2-{[(3,4-二甲氧基-2-吡啶基)甲基]硫}-1H-苯并咪唑

  • 409098-86-8

    2-{[(4-Chloro-3-methoxy-2-pyridinyl)methyl]sulfinyl}-6-(difluorom ethoxy)-1H-benzimidazole

  • 97963-62-7

    5-二氟甲氧基-2-巯基-1H-苯并咪唑

  • 72830-09-2

    2-(氯甲基)-3,4-二甲氧基吡啶盐酸盐

下游产品

更多
  • 102625-70-7

    潘托拉唑

立即下载安装“化学加”APP
专业、功能强大,随时调用更加方便