cas号： 78-00-2 ，名称： 4-乙酰氧基苯甲醛的性质/作用/用途-化学加百科

4-乙酰氧基苯甲醛

4-乙酰氧基苯甲醛基本信息
CAS号	78-00-2	分子式	C8H20Pb
分子量	323.46572	精确质量	324.13314
PSA	0.00000	LogP	3.51480

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基本信息制备方法与用途物化性质安全信息合成路线毒性 MSDS 结构与计算数据上下游

基本信息展开↓

CAS号：: 78-00-2
3D弹球模型：: 立即前往扯扯看
分子式：: C8H20Pb
分子量：: 323.46572
中文名称：: 4-乙酰氧基苯甲醛
英文名称：: Plumbane, tetraethyl-
中文别名：: 4-乙酰氧基苯甲醛;
四乙基铅;
四乙鉛
英文别名：: Plumbane, tetraethyl-;
Tetraethylplumbane;
Lead, tetraethyl-;
NSC 22314;
TEL;
Tetraethyllead
精确分子量/精确质量：: 324.13314
极性分子表面积/PSA：: 0.00000
油水分配系数/LogP：: LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值，反映了物质在油水两相中的分配情况。其中、LogP值越大，说明该物质越亲油；反之，LogP值越小，则说明该物质越亲水。
贝尔斯坦号/MDL：: MFCD00072541
EINECS：: 201-075-4
PubChem：: 24865109
InChI：: The Key: MRMOZBOQVYRSEM-UHFFFAOYSA-N

生产制备方法及用途展开↓

制备方法

用于汽油抗震添加剂以提高其辛烷值,也用于有机合成。

用途简介

用途

用于汽油抗震添加剂以提高其辛烷值，也用于有机合成。^[29]

物化性质展开↓

外观与性状：: 淡黄色液体
密度：: 1.653 g/mL at 25 °C(lit.)
熔点：: −136 °C(lit.)
沸点：: 84-85 °C15 mm Hg(lit.)
闪点：: 84 °F
折射率：: n20/D 1.519(lit.)
存储条件/存储方法：: 库房通风低温干燥,与氧化剂、食品添加剂分开存放
稳定性相关：: 1.稳定性^[23] 稳定
2.禁配物^[24] 强氧化剂、强酸、强碱
3.避免接触的条件^[25] 受热
4.聚合危害^[26] 不聚合
5.分解产物^[27] 铅化物
其它信息：: 1.性状：无色油状液体，有臭味。^[1]
2.熔点（℃）：-136^[2]
3.沸点（℃）：198~202（分解）^[3]
4.相对密度（水=1）：1.66^[4]
5.相对蒸气密度（空气=1）：8.6^[5]
6.饱和蒸气压（kPa）：0.13（38.4℃）^[6]
7.临界压力（MPa）：2.13^[7]
8.辛醇/水分配系数：4.15^[8]
9.闪点（℃）：93.3（CC）；85（OC）^[9]
10.引燃温度（℃）：127^[10]
11.爆炸上限（%）：暂无资料
12.爆炸下限（%）：1.8^[11]
13.溶解性：不溶于水、稀酸、稀碱液，溶于多数有机溶剂。^[12]

安全信息展开↓

包装等级：: I
风险类别：: 6.1(a)
WGK_Germany：: 3
德国有关水污染物质的分类清单
危险类别码：: 61-26/27/28-33-50/53-62-38-10
安全说明：: S53-S45-S60-S61-S36/37-S26
RTECS号：: TP4550000
安全标志：: S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
S60:本物质残余物和容器必须作为危险废物处理。
S61:避免排放到环境中。参考专门的说明/安全数据表。
危险标志：: T+,N

合成路线查看所有的合成路线

79110-50-2

(η5-cyclopentadienyl)W(CO)3PbEt3
→
79123-28-7

{(η5-cyclopentadienyl)W(CO)3}2PbEt2
+
78-00-2

4-乙酰氧基苯甲醛

925-90-6

乙基溴化镁
+
41141-89-3

bromo(triethyl)plumbane
+
141-78-6

乙酸乙酯
→
78-00-2

4-乙酰氧基苯甲醛

1067-14-7

三乙基铅氯化物
+
71-43-2

苯
→
78-00-2

4-乙酰氧基苯甲醛

毒理性展开↓

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TP4550000

CHEMICAL NAME :: Plumbane, tetraethyl-

CAS REGISTRY NUMBER :: 78-00-2

BEILSTEIN REFERENCE NO. :: 3903146

LAST UPDATED :: 199712

DATA ITEMS CITED :: 67

MOLECULAR FORMULA :: C8-H20-Pb

MOLECULAR WEIGHT :: 323.47

WISWESSER LINE NOTATION :: 2-PB-2&2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 1749 gm/m3/30M

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 1470 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12300 ug/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Behavioral - aggression

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 850 mg/m3/1H

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 mg/m3/7H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 547 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 830 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 995 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 mg/m3/1H/5D-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Behavioral - convulsions or effect on seizure threshold Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 42 mg/kg/7D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg/21D-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 11 mg/kg

SEX/DURATION :: female 6-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 7500 ug/kg

SEX/DURATION :: female 12-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 3 mg/kg

SEX/DURATION :: female 14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - biochemical and metabolic

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1499 ug/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - hepatobiliary system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 3 mg/kg

SEX/DURATION :: female 19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - hepatobiliary system Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 11 mg/kg

SEX/DURATION :: female 5-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Embryo

REFERENCE :: AETODY Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980- Volume(issue)/page/year: 1,241,1980 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.1 mg/m3, monitoring (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,230,1987 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 23,325,1980 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,230,1987 TOXICOLOGY REVIEW JORCAI Journal of Organometallic Chemistry. (Elsevier Sequoia SA, POB 851, CH-1001 Lausanne l, Switzerland) V.1- 1963- Volume(issue)/page/year: 76,265,1974 TOXICOLOGY REVIEW JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 105,578,1935 TOXICOLOGY REVIEW FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 9,105,1971 TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965 TOXICOLOGY REVIEW 85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: Pb,255,1972 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.1 mg(Pb)/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,251,1971 OSHA PEL (Gen Indu):8H TWA 0.075 mg(Pb)/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.1 mg(Pb)/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.1 mg(Pb)/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.075 mg(Pb)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.1 mg/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.1 mg/m3;Skin JAN 1993 OEL-AUSTRIA:TWA 0.1 ppm (0.075 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 0.1 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.007 ppm (0.05 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 0.075 mg/m3;STEL 0.23 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 0.10 mg/m3;Skin JAN 1993 OEL-GERMANY:TWA 0.01 ppm (0.075 mg/m3);Skin JAN 1993 OEL-HUNGARY:TWA 0.005 mg/m3;STEL 0.01 mg/m3;Skin JAN 1993 OEL-JAPAN:TWA 0.075 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.15 mg/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.075 mg/m3;Skin JAN 1993 OEL-POLAND:TWA 0.005 mg/m3 JAN 1993 OEL-RUSSIA:STEL 0.005 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 0.05 mg/m3;STEL 0.2 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.01 ppm (0.075 mg/m3);STEL 0.02 ppm;Skin JAN 1993 OEL-THAILAND:TWA 0.075 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.10 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO TETRAETHYLLEAD (as Pb)-air:10H TWA 0.075 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 71640 No. of Facilities: 85 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 799 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 71640 No. of Facilities: 729 (estimated) No. of Industries: 6 No. of Occupations: 15 No. of Employees: 36802 (estimated) No. of Female Employees: 1099 (estimated)

毒理学数据：

1.急性毒性^[13]

LD50：12.3mg/kg（大鼠经口）

LC50：850mg/m³（大鼠吸入，1h）

2.刺激性 暂无资料

3.亚急性与慢性毒性^[14] 慢性中毒的主要病变在大脑皮层，尚有肝、肾实质器官的损伤。

4.致突变性^[15] 形态学转化：仓鼠胚胎12500μg/L。

5.致畸性^[16] 小鼠孕后13d腹腔内给予最低中毒剂量（TDLo）1499μg/kg，致中枢神经系统和肝胆管系统发育畸形。大鼠孕后19d腹腔内给予最低中毒剂量（TDLo）3mg/kg，致中枢神经系统、肝胆管系统和泌尿生殖系统发育畸形。

6.致癌性^[17] IARC致癌性评论：G3，对人及动物致癌性证据不足。

7.其他^[18] 大鼠经口最低中毒剂量（TDLo）：11mg/kg（孕6~16d），引起胚胎毒性（如胚胎发育迟缓）。

生态数据：

1.生态毒性^[19]

LC50：0.02~0.23mg/L（96h）（鱼）

EC50：0.02mg/L（48h）（水蚤）

IC50：0.1mg/L（72h）（藻类）

2.生物降解性^[20]

好氧生物降解（h）：168~672

厌氧生物降解（h）：672~2688

3.非生物降解性^[21]

水相光解半衰期（h）：2.3~9

空气中光氧化半衰期（h）：2.99~22.3

一级水解半衰期（h）：14.5

4.生物富集性^[22]

BCF：17600（东方生耗，接触浓度0.1μgPb/L）；18138（东方生耗，接触浓度0.8μgPb/L）

MSDS 展开↓

国标编号:	61097
ＣＡＳ:	78-00-2
中文名称:	四乙基铅
英文名称:	teraethyl lead；TEL
别名:	发动机燃料抗爆混合物
分子式:	C₈H₂₀Pb；(CH₃CH₂)₄Pb
分子量:	323.44
熔点:	-136℃ 沸点：198～20
密度:	相对密度(水=1)1.66
蒸汽压:	93.3℃
溶解性:	不溶于水、稀酸、稀碱液，溶于多数有机溶剂
稳定性:	稳定
外观与性状:	无色油状液体，有臭味
危险标记:	13(剧毒品)
用途:	用于汽油抗震添加剂，提高辛烷值，及用于有机合成

2.对环境的影响:
一、健康危害

侵入途径：吸入、食入、经皮吸收。
健康危害：四乙基铅为剧烈的神经毒物，易侵犯中枢神经系统。急性中毒：初期症状有睡眠障碍，全身无力、情绪不稳、植物神经功能紊乱，往往有血压、体温、脉率低现象(三低症)等，严重者发生中毒性脑病，出现谵妄、精神异常、昏迷、抽搐等，可有心脏和呼吸功能障碍，高浓度下可立即死亡。慢性中毒：主表现为神经衰弱综合症和植物神经功能紊乱。可有(三低症)和脑电图异常。
二、毒理学资料

急性毒性：LD₅₀12.3mg/kg(小鼠经口)；LC₅₀850mg/m³，1小时(大鼠吸入)
亚急性和慢性中毒：大鼠灌胃0.00008mg/(kg.天)，134～160天，心肌、肾脏、脾脏变性坏死，伴有炎症渗出增生改变。
生殖毒性：大鼠经口最低中毒剂量3(TDL₀)11 mg/Kg(孕6～16天)，引起胚胎毒性。
致癌性：IARC致癌性评论：动物不明确。四乙基铅的动物试验表明可能引发癌症。Epstem和Mcntc给出生21天小鼠皮下注射0.6mg四乙基铅(分4次等剂量)，发现恶性淋巴癌发生北明显增加，在第一次注射后的36至51周之间就观察到3个肿瘤。

代谢和降解：生物体内的四乙基铅不甚稳定，四乙基铅蒸气压在20℃时为3.3×10^-2kPa，但被肺吸收的速度很快，所以经肺是四乙基铅的主要入侵途径。其次因四乙基铅是脂溶性化合物，所以也比较容易被皮肤及粘膜所吸收。所以如果皮肤长期接触四乙基铅汽油，则有中毒的危险，被吸收的四乙基铅，容易通过血脑屏障，大量转移到脑内。在环境中的四乙基铅，经光和热的作用，逐步降解为三乙基铅，再进一步降解为无机铅。人体组织中的四乙基铅，经过经14天后就全部代谢变成无机铅，而作为加铅汽油中与四乙基铅混合使用的四甲基铅，其降解速度则慢得多。

四乙基铅的中毒症状与无机铅有所不同，以中枢神经系统的症状表现最为强烈，但几乎不影响造血器官，多数伴有消化系统症状。重度四乙基铅中毒有晕眩，头沉、头痛、失眠及食欲不振等初发症状、数日之中很快恶化，引起精神亢奋、幻觉、妄想及痉挛等，经昏迷、衰竭而死亡。作为一般的中毒症状，常能看到头昏、恶梦、急躁、多动等。
危险特性：易燃，遇明火、高热能引起燃烧爆炸。遇水或受热分解放出有毒的腐蚀性气体。
燃烧(分解)产物：一氧化碳、二氧化碳、氯化氢。

3.现场应急监测方法:

　

4.实验室监测方法:

双硫腙比色法《空气中有害物质的测定方法》(第二版)，杭士平主编
原子吸收法《作业环境空气中有毒物质检测方法》，陈安之主编
气相色谱法，参照《分析化学手册》(第四分册，色谱分析)，化学工业出版社

5.环境标准:

中国(TJ36-79)	车间空气中有害物质的最高容许浓度	0.005mg/m³ [皮]
中国(待颁布)	饮用水源中有害物质的最高容许浓度	不得检出
前苏联(1975)	污水中有机物最大允许浓度	0.001mg/L

6.应急处理处置方法:

一、泄漏应急处理

迅速撤离泄漏污染区人员至安全区，并进行隔离，严格限制出入。切断火源。建议应急处理人员戴自给正压式呼吸器，穿防毒服。不要直接接触泄漏物。尽可能切断泄漏源。防止进入下水道、排洪沟等限制性空间。小量泄漏：用砂土或其它不燃材料吸附或吸收。大量泄漏：构筑围堤或挖坑收容；用泡沫覆盖，降低蒸气灾害。用泵转移至槽车或专用收集器内，回收或运至废物处理场所处置。
废弃物处置方法：用控制焚烧法。经洗涤器收集的铅氧化物可再循环使用或填埋处理。从废水中回收烷基铅化合物。
二、防护措施

呼吸系统防护：可能接触其蒸气时，必须佩戴自吸过滤式防毒面具(全面罩)。紧急事态抢救或撤离时，佩戴空气呼吸器。
眼睛防护：呼吸系统防护中已作防护。
身体防护：穿胶布防毒衣。
手防护：戴防化学品手套。
其它：工作现场禁止吸烟、进食和饮水。工作毕，彻底清洗。单独存放被毒物污染的衣服，洗后备用。实行就业前和定期的体检。
三、急救措施

皮肤接触：脱去被污染的衣着，用肥皂水和清水彻底冲洗皮肤，就医。
眼睛接触：提起眼睑，用流动清水或生理盐水冲洗，就医。
吸入：迅速脱离现场至空气新鲜处。保持呼吸道通畅。如呼吸困难，给输氧。如呼吸停止，立即进行人工呼吸。就医。
食入：饮足量温水，催吐，就医。

灭火方法：消防人员须佩戴防毒面具、穿全身消防服。灭火剂：雾状水、泡沫、二氧化碳、砂土。

分子结构与计算化学数据展开↓

分子结构数据

1、摩尔折射率：无可用

2、摩尔体积（cm³/mol）：无可用

3、等张比容（90.2K）：无可用

4、表面张力（dyne/cm）：无可用

5、介电常数：无可用

6、偶极距（10^-24cm³）：无可用

7、极化率：无可用

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:0

3.氢键受体数量:0

4.可旋转化学键数量:4

5.互变异构体数量:无

6.拓扑分子极性表面积0

7.重原子数量:9

8.表面电荷:0

9.复杂度:47.5

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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